中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

4 records (took 0.014 seconds)

    Human Antigen Binding Proteins That Bind Beta-Klotho, FGF Receptors and Complexes Thereof
    3.
    发明申请
    Human Antigen Binding Proteins That Bind Beta-Klotho, FGF Receptors and Complexes Thereof 审中-公开

    公开(公告)号：US20200216546A1

    公开(公告)日：2020-07-09

    申请号：US16744734

    申请日：2020-01-16

    Applicant: Amgen, Inc.

    Inventor： Shaw-Fen Sylvia HU ,  Ian Nevin FOLTZ ,  Chadwick Terence KING ,  Yang LI ,  Taruna ARORA

    IPC: C07K16/28 ,  C07K16/18 ,  C07K14/71 ,  C07K16/40

    Abstract: The present invention provides compositions and methods relating to or derived from antigen binding proteins activate FGF21-mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i) β-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to (i) β-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.

Patent Agency Ranking