System and method for mild cognitive impairment class discovery using gene expression data
    1.
    发明授权
    System and method for mild cognitive impairment class discovery using gene expression data 有权
    使用基因表达数据进行轻度认知障碍类发现的系统和方法

    公开(公告)号:US07945390B2

    公开(公告)日:2011-05-17

    申请号:US11249004

    申请日:2005-10-12

    IPC分类号: G01N33/50

    摘要: A system and method for mild cognitive impairment (MCI) class discovery using gene expression data are provided. The method comprises: acquiring gene expression data of a patient having MCI; and identifying a putative MCI subtype based on an expression signature in the gene expression data, wherein the putative MCI subtype is identified by using a boosting tree.

    摘要翻译: 提供了使用基因表达数据的轻度认知障碍(MCI)类发现的系统和方法。 该方法包括:获取具有MCI的患者的基因表达数据; 以及基于所述基因表达数据中的表达特征识别推定的MCI亚型,其中通过使用增强树来鉴定推定的MCI亚型。

    System and method for molecular diagnosis of depression based on boosting classification
    2.
    发明授权
    System and method for molecular diagnosis of depression based on boosting classification 失效
    基于增强分类的抑郁症分子诊断系统和方法

    公开(公告)号:US07707134B2

    公开(公告)日:2010-04-27

    申请号:US11329528

    申请日:2006-01-11

    IPC分类号: G06F17/00 G06N5/04

    CPC分类号: G06F19/24

    摘要: A method for diagnosing depression includes providing surface-enhanced laser desorption/ionization mass spectrometric (SELDI-MS) data of a plurality of proteins, said data obtained from a patient and comprising a plurality of peak values, and analyzing said peak values with an alternating decision tree comprising a set of tests of said data peaks values and associated prediction values, wherein said data is predictive of depression if a sum of the prediction values of said tree is greater than 1.0.

    摘要翻译: 用于诊断抑郁症的方法包括提供多个蛋白质的表面增强激光解吸/电离质谱(SELDI-MS)数据,所述数据从患者获得并包括多个峰值,并且用交替的方法分析所述峰值 决策树,其包括所述数据峰值和相关联的预测值的一组测试,其中如果所述树的预测值之和大于1.0,则所述数据预示着抑制。

    System and Method For Integrating Heterogeneous Biomedical Information
    3.
    发明申请
    System and Method For Integrating Heterogeneous Biomedical Information 审中-公开
    用于整合异构生物医学信息的系统和方法

    公开(公告)号:US20070130206A1

    公开(公告)日:2007-06-07

    申请号:US11462616

    申请日:2006-08-04

    IPC分类号: G06F17/00

    摘要: A system and method for using heterogeneous data from multiple healthcare information sources in a medical decision support system is disclosed. Each healthcare information system stores medical data using a different local schema. The medical decision support system provides responses to user queries. A query is received from a user that is generated in a standardized global schema. The query includes information from medical ontologies. Database queries are generated from the user queries that use the medical ontologies to generate constraints in the queries. The medical ontologies are also used to infer database queries. The generated query is translated into multiple queries for the multiple healthcare systems wherein each query is in the local schema of the healthcare information system that is being queried. Each database query is transmitted to one of the healthcare information systems based on the local schema of the particular query. Data is collected from each of the queried healthcare information system and analyzed. A query response is formulated for the user

    摘要翻译: 公开了一种在医疗决策支持系统中使用来自多个保健信息源的异构数据的系统和方法。 每个保健信息系统使用不同的本地模式存储医疗数据。 医疗决策支持系统提供对用户查询的响应。 从标准化全局模式中生成的用户接收到查询。 该查询包括医学本体的信息。 数据库查询是从使用医学本体的用户查询生成查询中的约束生成的。 医学本体也用于推断数据库查询。 所生成的查询被转换成多个医疗保健系统的多个查询,其中每个查询在被查询的医疗保健信息系统的本地模式中。 基于特定查询的本地模式,将每个数据库查询发送到医疗保健信息系统之一。 从每个被查询的医疗信息系统收集数据并进行分析。 为用户制定了查询响应

    System and method for molecular diagnosis of depression based on boosting classification
    4.
    发明申请
    System and method for molecular diagnosis of depression based on boosting classification 失效
    基于增强分类的抑郁症分子诊断系统和方法

    公开(公告)号:US20060184496A1

    公开(公告)日:2006-08-17

    申请号:US11329528

    申请日:2006-01-11

    IPC分类号: G06F15/18

    CPC分类号: G06F19/24

    摘要: A method for diagnosing depression includes providing surface-enhanced laser desorption/ionisation mass spectrometric (SELDI-MS) data of a plurality of proteins, said data obtained from a patient and comprising a plurality of peak values, and analysing said peak values with an alternating decision tree comprising a set of tests of said data peaks values and associated prediction values, wherein said data is predictive of depression if a sum of the prediction values of said tree is greater than 1.0.

    摘要翻译: 用于诊断抑郁症的方法包括提供多个蛋白质的表面增强激光解吸/电离质谱(SELDI-MS)数据,所述数据从患者获得并包括多个峰值,并且用交替的方式分析所述峰值 决策树,其包括所述数据峰值和相关联的预测值的一组测试,其中如果所述树的预测值之和大于1.0,则所述数据预示着抑制。

    System and method for automatic molecular diagnosis of ALS based on boosting classification
    5.
    发明授权
    System and method for automatic molecular diagnosis of ALS based on boosting classification 失效
    基于增强分类的ALS自动分子诊断系统和方法

    公开(公告)号:US07356521B2

    公开(公告)日:2008-04-08

    申请号:US11330535

    申请日:2006-01-12

    IPC分类号: G06N5/00

    摘要: A method for diagnosing Amyotrophic lateral sclerosis includes providing surface-enhanced laser desorption/ionisation mass spectrometric (SELDI-MS) data of a plurality of proteins, said data obtained from a patient and comprising a plurality of peak values, and analysing said peak values with an alternating decision tree comprising a set of tests of said data peaks values and associated prediction values, wherein said data is predictive of depression if a sum of the prediction values of said tree is greater than 1.0.

    摘要翻译: 用于诊断肌萎缩性侧索硬化症的方法包括提供多个蛋白质的表面增强激光解吸/电离质谱(SELDI-MS)数据,所述数据从患者获得并包括多个峰值,并且分析所述峰值与 交替决策树,其包括所述数据峰值和相关联的预测值的一组测试,其中如果所述树的预测值之和大于1.0,则所述数据预示着抑制。

    System and method for automatic molecular diagnosis of ALS based on boosting classification
    7.
    发明申请
    System and method for automatic molecular diagnosis of ALS based on boosting classification 失效
    基于增强分类的ALS自动分子诊断系统和方法

    公开(公告)号:US20060218109A1

    公开(公告)日:2006-09-28

    申请号:US11330535

    申请日:2006-01-12

    IPC分类号: G06N3/08

    摘要: A method for diagnosing Amyotrophic lateral sclerosis includes providing surface-enhanced laser desorption/ionisation mass spectrometric (SELDI-MS) data of a plurality of proteins, said data obtained from a patient and comprising a plurality of peak values, and analysing said peak values with an alternating decision tree comprising a set of tests of said data peaks values and associated prediction values, wherein said data is predictive of depression if a sum of the prediction values of said tree is greater than 1.0.

    摘要翻译: 用于诊断肌萎缩性侧索硬化症的方法包括提供多个蛋白质的表面增强激光解吸/电离质谱(SELDI-MS)数据,所述数据从患者获得并包括多个峰值,并且分析所述峰值与 交替决策树,其包括所述数据峰值和相关联的预测值的一组测试,其中如果所述树的预测值之和大于1.0,则所述数据预示着抑制。

    SYSTEM AND METHOD FOR SEMANTIC INDEXING AND NAVIGATION OF VOLUMETRIC IMAGES
    9.
    发明申请
    SYSTEM AND METHOD FOR SEMANTIC INDEXING AND NAVIGATION OF VOLUMETRIC IMAGES 有权
    体积图像的语义索引和导航的系统和方法

    公开(公告)号:US20070127798A1

    公开(公告)日:2007-06-07

    申请号:US11532556

    申请日:2006-09-18

    IPC分类号: G06K9/00

    摘要: A method for navigating digital medical images includes providing a digitized patient medical image of a structure of interest in a patient, using a pre-trained classifier to segment the structure of interest from the image, creating links from the structure of interest to a corresponding structure in an anatomical atlas, receiving a query to view the structure of interest, parsing the query to identify one or more keywords from noun phrases in the query, mapping a keyword to a corresponding structure in the anatomical atlas, wherein the anatomical atlas structure is associated with a link to the corresponding structure in the patient image, and following the link to display said patient structure of interest.

    摘要翻译: 用于导航数字医学图像的方法包括使用预训练的分类器从图像中分割感兴趣的结构,从感兴趣的结构到相应的结构建立链接来提供患者的感兴趣的结构的数字化的患者医学图像 在解剖图谱中,接收查询以查看感兴趣的结构,解析查询以从查询中的名词短语识别一个或多个关键词,将关键字映射到解剖图谱中的对应结构,其中解剖图谱结构相关联 具有到患者图像中的对应结构的链接,并且跟随链接以显示感兴趣的所述患者结构。