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公开(公告)号：US20150037359A1
公开(公告)日：2015-02-05
申请号：US14381199
申请日：2013-02-27
发明人： Volker Schellenberger , Vladimir Podust , Chia-Wei Wang , Bryant McLaughlin , Bee-Cheng Sim , Sheng Ding , Chen Gu
CPC分类号： A61K38/24 , A61K47/64 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07K5/0205
摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
摘要翻译： 本发明涉及延伸的重组多肽（XTEN）组合物，包含与用于与药理活性有效载体缀合的交联剂连接的XTEN和XTEN的缀合物组合物，制备高度纯化的XTEN的方法，制备XTEN-接头和XTEN-有效载体缀合物的方法 以及使用XTEN-交联剂和XTEN-有效载体组合物的方法。
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公开(公告)号：US10953073B2
公开(公告)日：2021-03-23
申请号：US16133444
申请日：2018-09-17
发明人： Volker Schellenberger , Vladimir Podust , Chia-Wei Wang , Bryant McLaughlin , Bee-Cheng Sim , Sheng Ding , Chen Gu
摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
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公开(公告)号：US10172953B2
公开(公告)日：2019-01-08
申请号：US14381199
申请日：2013-02-27
发明人： Volker Schellenberger , Vladimir Podust , Chia-Wei Wang , Bryant McLaughlin , Bee-Cheng Sim , Sheng Ding , Chen Gu
摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
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