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公开(公告)号：US09371369B2
公开(公告)日：2016-06-21
申请号：US14168973
申请日：2014-01-30
发明人： Volker Schellenberger , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , Wayne To , Jeffrey L. Cleland
IPC分类号： A61K38/16 , A61K38/18 , C07K14/61 , C07K14/46 , C07K14/545 , C07K14/00 , C07K14/605 , C07K14/745 , C07K14/47
CPC分类号： C07K14/47 , C07K14/001 , C07K14/545 , C07K14/605 , C07K14/61 , C07K14/745 , C07K2319/31 , C07K2319/35 , C12N9/6437 , C12N9/644
摘要： The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的生物活性蛋白质的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及使用这些组合物治疗葡萄糖相关疾病，代谢疾病 ，凝血障碍和生长激素相关的疾病和病症。
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公开(公告)号：US20150037359A1
公开(公告)日：2015-02-05
申请号：US14381199
申请日：2013-02-27
发明人： Volker Schellenberger , Vladimir Podust , Chia-Wei Wang , Bryant McLaughlin , Bee-Cheng Sim , Sheng Ding , Chen Gu
CPC分类号： A61K38/24 , A61K47/64 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07K5/0205
摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
摘要翻译： 本发明涉及延伸的重组多肽（XTEN）组合物，包含与用于与药理活性有效载体缀合的交联剂连接的XTEN和XTEN的缀合物组合物，制备高度纯化的XTEN的方法，制备XTEN-接头和XTEN-有效载体缀合物的方法 以及使用XTEN-交联剂和XTEN-有效载体组合物的方法。
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公开(公告)号：US10953073B2
公开(公告)日：2021-03-23
申请号：US16133444
申请日：2018-09-17
发明人： Volker Schellenberger , Vladimir Podust , Chia-Wei Wang , Bryant McLaughlin , Bee-Cheng Sim , Sheng Ding , Chen Gu
摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
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公开(公告)号：US20190083577A1
公开(公告)日：2019-03-21
申请号：US16133444
申请日：2018-09-17
发明人： Volker Schellenberger , Vladimir Podust , Chia-Wei Wang , Bryant MCLAUGHLIN , Bee-Cheng Sim , Sheng Ding , Chen Gu
摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
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公开(公告)号：US10172953B2
公开(公告)日：2019-01-08
申请号：US14381199
申请日：2013-02-27
发明人： Volker Schellenberger , Vladimir Podust , Chia-Wei Wang , Bryant McLaughlin , Bee-Cheng Sim , Sheng Ding , Chen Gu
摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
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公开(公告)号：US09938331B2
公开(公告)日：2018-04-10
申请号：US14970723
申请日：2015-12-16
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Nathaniel C. Gordon , Andreas Crameri , Mikhail Popkov
IPC分类号： C07K1/00 , A61K38/24 , C07K14/00 , C07K14/56 , C07K7/06 , C07K7/08 , C07K14/415 , C12N15/10 , G01N33/68 , C07K14/47 , C07K14/53 , C07K14/61 , C07K14/535 , A61K38/00
CPC分类号： C07K14/56 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/415 , C07K14/47 , C07K14/53 , C07K14/535 , C07K14/61 , C07K2319/31 , C07K2319/35 , C12N15/1044 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
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7.发明申请BIOLOGICALLY ACTIVE PROTEINS HAVING INCREASED IN VIVO AND/OR IN VITRO STABILITY 有权生物活性蛋白在体内和/或体内稳定性增加公开(公告)号：US20160280753A1
公开(公告)日：2016-09-29
申请号：US14970723
申请日：2015-12-16
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Nathaniel C. Gordon , Andreas Crameri , Mikhail Popkov
IPC分类号： C07K14/56 , C07K7/08 , C07K7/06 , C07K14/535 , C07K14/61
CPC分类号： C07K14/56 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/415 , C07K14/47 , C07K14/53 , C07K14/535 , C07K14/61 , C07K2319/31 , C07K2319/35 , C12N15/1044 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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公开(公告)号：US20150038421A1
公开(公告)日：2015-02-05
申请号：US14317888
申请日：2014-06-27
发明人： Volker SCHELLENBERGER , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
IPC分类号： C07K14/755 , C07K14/00
CPC分类号： C07K14/755 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/41 , C07K2319/50 , C07K2319/95
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
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9.发明申请BIOLOGICALLY ACTIVE PROTEINS HAVING INCREASED IN VIVO AND/OR IN VITRO STABILITY 审中-公开生物活性蛋白在体内和/或体内稳定性增加公开(公告)号：US20140356326A1
公开(公告)日：2014-12-04
申请号：US14102297
申请日：2013-12-10
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-Wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
CPC分类号： C07K14/56 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/415 , C07K14/47 , C07K14/53 , C07K14/535 , C07K14/61 , C07K2319/31 , C07K2319/35 , C12N15/1044 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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10.发明申请COAGULATION FACTOR VII COMPOSITIONS AND METHODS OF MAKING AND USING SAME 审中-公开凝血因子VII组合物及其制备方法和使用方法公开(公告)号：US20140328819A1
公开(公告)日：2014-11-06
申请号：US14218524
申请日：2014-03-18
发明人： Volker Schellenberger , Joshua Silverman , Willem Peter Stemmer , Chia-Wei Wang , Benjamin Spink , Nathan Carl Geething , Wayne To
IPC分类号： C12N9/64
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VII凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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