公开(公告)号：US20050106657A1

公开(公告)日：2005-05-19

申请号：US10498682

申请日：2002-12-20

申请人： Ana Marcos Rodriguez ,  Antonio Estrella De Castro ,  Javier Costa Perez ,  Manuel Oliver Ruiz ,  Nieves Fraile Yecora ,  Juan De La Fuente Moreno ,  Marta Saiz ,  Bruno Diez Garcia ,  Enrieque Peiro Cezon ,  Angel Ruiz ,  Walter Cabri ,  Juan Lopez Ortiz ,  Jose Barredo Fuente

发明人： Ana Marcos Rodriguez ,  Antonio Estrella De Castro ,  Javier Costa Perez ,  Manuel Oliver Ruiz ,  Nieves Fraile Yecora ,  Juan De La Fuente Moreno ,  Marta Saiz ,  Bruno Diez Garcia ,  Enrieque Peiro Cezon ,  Angel Ruiz ,  Walter Cabri ,  Juan Lopez Ortiz ,  Jose Barredo Fuente

IPC分类号： A23L5/44 ,  A23L33/105 ,  A23L33/15 ,  A61K8/18 ,  A61K8/31 ,  A61K9/107 ,  A61K47/06 ,  A61Q1/02 ,  C12P23/00 ,  C12R1/645 ,  C12N1/16

CPC分类号： C12P23/00 ,  A23L5/44 ,  A23L33/105 ,  A23L33/15 ,  A61K9/1075 ,  C12R1/645 ,  Y02E50/343

摘要： The method of fermentation with selected strains of B. trispora described in the present invention makes it possible to achieve lycopene yields higher than those currently described. The methods of isolation, purification and formulation are applicable to any natural source of lycopene, especially to submerged cultures of mucoral fungi of the genera Blakeslea, Choanephora, Phycomyces or Mucor. The method of extraction makes it possible to simplify the recovery process and increase the purity of the product, relative to the methods previously described. The methods of formulation provide high added value, since they make it possible to obtain stabilized preparations of lycopene for direct application in the food and pharmaceutical fields.

摘要翻译： 使用本发明中所述的三孢菌的选择菌株发酵的方法使得可以获得高于目前所述的番茄红素产量。 分离，纯化和配制的方法适用于番茄红素的任何天然来源，特别是适用于Blakeslea，Choanephora，Phycomyces或Mucor的粘液真菌的浸没培养物。 相对于先前描述的方法，萃取方法使得可以简化回收过程并提高产物的纯度。 配制方法提供高附加值，因为它们可以获得用于直接应用于食品和药物领域的稳定的番茄红素制剂。

公开(公告)号：US07799540B2

公开(公告)日：2010-09-21

申请号：US10498682

申请日：2002-12-20

申请人： Ana Teresa Marcos Rodríguez ,  Antonio Estrella De Castro ,  Javier Costa Perez ,  Manuel Antonio Oliver Ruiz ,  Nieves Fraile Yecora ,  Juan Luis De La Fuente Moreno ,  Marta Rodríguez Saiz ,  Bruno Diez Garcia ,  Enrieque Peiro Cezon ,  Angel Muñoz Ruiz ,  Walter Cabri ,  Juan Francisco Lopez Ortiz ,  José Luis Barredo Fuente

发明人： Ana Teresa Marcos Rodríguez ,  Antonio Estrella De Castro ,  Javier Costa Perez ,  Manuel Antonio Oliver Ruiz ,  Nieves Fraile Yecora ,  Juan Luis De La Fuente Moreno ,  Marta Rodríguez Saiz ,  Bruno Diez Garcia ,  Enrieque Peiro Cezon ,  Angel Muñoz Ruiz ,  Walter Cabri ,  Juan Francisco Lopez Ortiz ,  José Luis Barredo Fuente

IPC分类号： C12P23/00 ,  C12P5/00 ,  C07C403/00

CPC分类号： C12P23/00 ,  A23L5/44 ,  A23L33/105 ,  A23L33/15 ,  A61K9/1075 ,  C12R1/645 ,  Y02E50/343

摘要： The method of fermentation with selected strains of B. trispora described in the present invention makes it possible to achieve lycopene yields higher than those currently described. The methods of isolation, purification and formulation are applicable to any natural source of lycopene, especially to submerged cultures of mucoral fungi of the genera Blakeslea, Choanephora, Phycomyces or Mucor. The method of extraction makes it possible to simplify the recovery process and increase the purity of the product, relative to the methods previously described. The methods of formulation provide high added value, since they make it possible to obtain stabilized preparations of lycopene for direct application in the food and pharmaceutical fields.

摘要翻译： 使用本发明中所述的三孢菌的选择菌株发酵的方法使得可以获得高于目前所述的番茄红素产量。 分离，纯化和配制的方法适用于番茄红素的任何天然来源，特别是适用于Blakeslea，Choanephora，Phycomyces或Mucor的粘液真菌的浸没培养物。 相对于先前描述的方法，萃取方法使得可以简化回收过程并提高产物的纯度。 配制方法提供高附加值，因为它们可以获得用于直接应用于食品和药物领域的稳定的番茄红素制剂。

公开(公告)号：US20050079223A1

公开(公告)日：2005-04-14

申请号：US10498434

申请日：2002-12-20

申请人： Antonio Estrella De Castro ,  Nieves Fraile Yecora ,  Manuel Oliver Ruiz ,  Angel Muñoz ,  Juan Lopez Ortiz ,  Walter Cabri

发明人： Antonio Estrella De Castro ,  Nieves Fraile Yecora ,  Manuel Oliver Ruiz ,  Angel Muñoz ,  Juan Lopez Ortiz ,  Walter Cabri

IPC分类号： A23L1/275 ,  A23L1/30 ,  A23L1/303 ,  A61K8/30 ,  A61K8/34 ,  A61K9/16 ,  A61K9/50 ,  A61K31/015 ,  A61K31/355 ,  C07C403/02

CPC分类号： C07C403/24

摘要： The present invention describes a method of preparation of formulations of microcrystalline lutein, particularly in the form of esters, which are resistant to oxidation and are soluble in hydrophilic and/or lipophilic media. For these formulations, the esters of lutein are mixed with antioxidants, vegetable oils and/or organic solvents, and this initial mixture is submitted to various stages depending on the type of final formulation required. These formulations are suitable for direct application as colourants in the pharmaceutical, food and cosmetics fields. They can also be used as diet supplements.

摘要翻译： 本发明描述了一种制备微晶叶黄素制剂的方法，特别是以酯的形式，它们耐氧化并且可溶于亲水和/或亲脂性介质。 对于这些制剂，叶黄素的酯与抗氧化剂，植物油和/或有机溶剂混合，并且根据所需的最终制剂的类型将该初始混合物进行各种阶段。 这些制剂适合直接用作制药，食品和化妆品领域的着色剂。 它们也可以用作饮食补品。

公开(公告)号：US07045643B2

公开(公告)日：2006-05-16

申请号：US10498434

申请日：2002-12-20

申请人： Antonio Estrella De Castro ,  Nieves Fraile Yecora ,  Manuel Oliver Ruiz ,  Angel Muñoz ,  Juan Francisco Lopez Oritz ,  Walter Cabri

发明人： Antonio Estrella De Castro ,  Nieves Fraile Yecora ,  Manuel Oliver Ruiz ,  Angel Muñoz ,  Juan Francisco Lopez Oritz ,  Walter Cabri

IPC分类号： C11B3/00

CPC分类号： C07C403/24

摘要： The present invention describes a method of preparation of formulations of microcrystalline lutein, particularly in the form of esters, which are resistant to oxidation and are soluble in hydrophilic and/or lipophilic media. For these formulations, the esters of lutein are mixed with antioxidants, vegetable oils and/or organic solvents, and this initial mixture is submitted to various stages depending on the type of final formulation required. These formulations are suitable for direct application as colourants in the pharmaceutical, food and cosmetics fields. They can also be used as diet supplements.

摘要翻译： 本发明描述了一种制备微晶叶黄素制剂的方法，特别是以酯的形式，它们耐氧化并且可溶于亲水和/或亲脂性介质。 对于这些制剂，叶黄素的酯与抗氧化剂，植物油和/或有机溶剂混合，并且根据所需的最终制剂的类型将该初始混合物进行各种阶段。 这些制剂适合直接用作制药，食品和化妆品领域的着色剂。 它们也可以用作饮食补品。