公开(公告)号：US06316414B1

公开(公告)日：2001-11-13

申请号：US09629371

申请日：2000-07-31

申请人： Anand C. Burman ,  Sudhanand Prasad ,  Rama Mukherjee ,  Manu Jaggi ,  Anu T. Singh ,  Archna Mathur

发明人： Anand C. Burman ,  Sudhanand Prasad ,  Rama Mukherjee ,  Manu Jaggi ,  Anu T. Singh ,  Archna Mathur

IPC分类号： A61K3800

CPC分类号： C07K14/6555 ,  A61K38/00

摘要： The present invention encompasses novel peptides that are agonists to somatostatin and the use of the agonists for treatment of cancer. The invention particularly relates to the design and synthesis of novel analogs of somatostatin incorporating &agr;, &agr;-dialkylated amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.

摘要翻译： 本发明包括作为促生长抑素激动剂的新型肽以及激动剂用于治疗癌症的用途。 本发明特别涉及以特异性位点结合α，α-二烷基化氨基酸的生长抑素的新型类似物的设计和合成。 本发明包括产生这些肽的方法，含有肽的组合物和这些肽的药理学应用，特别是在治疗和预防癌症中。

公开(公告)号：US06989371B1

公开(公告)日：2006-01-24

申请号：US09630333

申请日：2000-07-31

申请人： Anand C. Burman ,  Sudhanand Prasad ,  Rama Mukherjee ,  Manu Jaggi ,  Anu T. Singh ,  Archna Mathur

发明人： Anand C. Burman ,  Sudhanand Prasad ,  Rama Mukherjee ,  Manu Jaggi ,  Anu T. Singh ,  Archna Mathur

IPC分类号： A61K38/00 ,  C07K7/00

CPC分类号： C07K7/086 ,  A61K38/00

摘要： The present invention encompasses novel peptides that are antagonists to bombesin and bombesin like peptides and are useful in the treatment of cancer. The invention particularly relates to the design and synthesis of the novel peptides incorporating α,α-amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.

摘要翻译： 本发明包括作为铃蟾肽和铃蟾肽样肽的拮抗剂的新型肽，并且可用于治疗癌症。 本发明特别涉及以位点特异性方式结合α，α-氨基酸的新型肽的设计和合成。 本发明包括产生这些肽的方法，含有肽的组合物和这些肽的药理学应用，特别是在治疗和预防癌症中。

公开(公告)号：US07094755B2

公开(公告)日：2006-08-22

申请号：US10254569

申请日：2002-09-25

申请人： Anand C. Burman ,  Sudhanand Prasad ,  Rama Mukherjee ,  Anu T. Singh ,  Archna Mathur ,  Neena Gupta

发明人： Anand C. Burman ,  Sudhanand Prasad ,  Rama Mukherjee ,  Anu T. Singh ,  Archna Mathur ,  Neena Gupta

IPC分类号： A61K38/16

CPC分类号： C07K14/57563 ,  A61K38/00 ,  Y10S930/17

摘要： The present invention encompasses novel analogs of vasoactive intestinal peptide (VIP), containing substitutions at appropriately selected amino acids. The invention particularly relates to the design and synthesis of novel biologically active VIP analogs containing α, α-dialkylated amino acids in a site-specific manner. Specifically, the invention relates to the synthesis of VIP peptide derivatives, which bind selectively to VIP receptors on target cells. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.

公开(公告)号：US06489297B1

公开(公告)日：2002-12-03

申请号：US09630335

申请日：2000-07-31

申请人： Anand C. Burman ,  Sudhanand Prasad ,  Rama Mukherjee ,  Anu T. Singh ,  Archna Mathur ,  Neena Gupta

发明人： Anand C. Burman ,  Sudhanand Prasad ,  Rama Mukherjee ,  Anu T. Singh ,  Archna Mathur ,  Neena Gupta

IPC分类号： A61K3816

CPC分类号： C07K14/57563 ,  A61K38/00 ,  Y10S930/17

摘要： The present invention encompasses novel analogs of vasoactive intestinal peptide (VIP), containing substitutions at appropriately selected amino acids. The invention particularly relates to the design and synthesis of novel biologically active VIP analogs containing &agr;,&agr;-dialkylated amino acids in a site-specific manner. Specifically, the invention relates to the synthesis of VIP peptide derivatives, which bind selectively to VIP receptors on target cells. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer,

摘要翻译： 本发明包括血管活性肠肽（VIP）的新类似物，其在适当选择的氨基酸处含有取代。 本发明特别涉及以位点特异性方式设计和合成含有α，α-二烷基化氨基酸的新型生物活性VIP类似物。 具体而言，本发明涉及VIP靶衍生物的合成，VIP衍生物选择性结合靶细胞上的VIP受体。 本发明包括产生这些肽的方法，含有肽的组合物和这些肽的药理学应用，特别是在治疗和预防癌症中，

公开(公告)号：US06949513B2

公开(公告)日：2005-09-27

申请号：US10186226

申请日：2002-06-28

申请人： Sudhanand Prasad ,  Rama Mukherjee ,  Anand C. Burman ,  Archna Mathur ,  Rajan Sharma ,  Manu Jaggi

发明人： Sudhanand Prasad ,  Rama Mukherjee ,  Anand C. Burman ,  Archna Mathur ,  Rajan Sharma ,  Manu Jaggi

IPC分类号： A61K38/00 ,  C07K14/575

CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K2319/00

摘要： A polypeptide of the formula (I), Pa-L-Pb-L-Pc-L-Pd.

摘要翻译： 式（I）的多肽，<？in-line-formula description =“In-line Formulas”end =“lead”？> P -β-in-line-formula description =“In-line Formulas”end =“tail”？>

公开(公告)号：US07060678B2

公开(公告)日：2006-06-13

申请号：US10638107

申请日：2003-08-08

申请人： Sudhanand Prasad ,  Tushar Kanti Chakraborty ,  Archna Mathur ,  Manu Jaggi ,  Ajit Chand Kunwar ,  Rama Mukherjee ,  Anand C. Burman

发明人： Sudhanand Prasad ,  Tushar Kanti Chakraborty ,  Archna Mathur ,  Manu Jaggi ,  Ajit Chand Kunwar ,  Rama Mukherjee ,  Anand C. Burman

IPC分类号： A61K38/07 ,  A61K38/08 ,  C07K5/02 ,  C07K7/02 ,  C07K9/00

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/1013 ,  C07K14/57563

摘要： Anticancer peptides which incorporate furanoid sugar amino acids and compositions made using these peptides are described. Methods for synthesis of the peptides and for preparing the furanoid sugar amino acids are disclosed. The peptides and compositions made using the peptides have pharmacological applications of these peptides especially in the treatment and prevention of cancer and tumors.

摘要翻译： 描述了掺入呋喃糖类氨基酸的抗癌肽和使用这些肽制备的组合物。 公开了合成肽和制备呋喃糖基氨基酸的方法。 使用肽制备的肽和组合物具有这些肽的药理学应用，特别是在治疗和预防癌症和肿瘤中。

公开(公告)号：US07781398B2

公开(公告)日：2010-08-24

申请号：US11643342

申请日：2006-12-21

申请人： Rama Mukherjee ,  Anand C. Burman ,  Anu T. Singh ,  Manu Jaggi ,  Sudhanand Prasad ,  Sarjana Dutt

发明人： Rama Mukherjee ,  Anand C. Burman ,  Anu T. Singh ,  Manu Jaggi ,  Sudhanand Prasad ,  Sarjana Dutt

IPC分类号： A01N37/10 ,  A61K38/00

CPC分类号： A61K38/08 ,  A61K2300/00

摘要： The present invention relates to a combination of peptides that may be used for treatment of cancer. The peptide combination competes for the binding of specific neuropeptides at the plasma membrane and thereby alters the levels of key intracellular molecules implicated in cell proliferation, resulting in a broad spectrum of anticancer activity. The invention also relates to pharmaceutical compositions containing a combination of such peptide analogs.

摘要翻译： 本发明涉及可用于治疗癌症的肽的组合。 肽组合竞争在质膜上特异性神经肽的结合，从而改变涉及细胞增殖的关键细胞内分子的水平，导致广谱的抗癌活性。 本发明还涉及含有这些肽类似物的组合的药物组合物。

公开(公告)号：US07173006B2

公开(公告)日：2007-02-06

申请号：US10329321

申请日：2002-12-23

申请人： Rama Mukherjee ,  Anand C. Burman ,  Anu T. Singh ,  Manu Jaggi ,  Sudhanand Prasad ,  Sarjana Dutt

发明人： Rama Mukherjee ,  Anand C. Burman ,  Anu T. Singh ,  Manu Jaggi ,  Sudhanand Prasad ,  Sarjana Dutt

IPC分类号： A61K38/00

CPC分类号： A61K38/08 ,  A61K2300/00

摘要： The present invention relates to a combination of peptides that may be used for treatment of cancer. The peptide combination competes for the binding of specific neuropeptides at the plasma membrane and thereby alters the levels of key intracellular molecules implicated in cell proliferation, resulting in a broad spectrum of anticancer activity. The invention also relates to pharmaceutical compositions containing a combination of such peptide analogs.

公开(公告)号：US06828304B1

公开(公告)日：2004-12-07

申请号：US09630345

申请日：2000-07-31

申请人： Anand C. Burman ,  Sudhanand Prasad ,  Rama Mukherjee ,  Manu Jaggi ,  Anu T. Singh ,  Rajan Sharma

发明人： Anand C. Burman ,  Sudhanand Prasad ,  Rama Mukherjee ,  Manu Jaggi ,  Anu T. Singh ,  Rajan Sharma

IPC分类号： A61K3800

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K14/57563

摘要： This invention relates to novel antiproliferative and anti secrectory peptides that are inhibitory to vasoactive intestinal peptide receptor and are useful in the treatment of cancer. The invention particularly relates to the synthesis of lipid-peptide conjugates containing fatty acids of different sizes, which inhibits the binding of VIP to its receptors. The invention encompasses methods for generation of these peptides, composition containing these peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.

摘要翻译： 本发明涉及抑制血管活性肠肽受体并可用于治疗癌症的新型抗增殖和抗分解肽。 本发明特别涉及含有不同大小的脂肪酸的脂质 - 肽缀合物的合成，其抑制VIP与其受体的结合。 本发明包括用于产生这些肽的方法，含有这些肽的组合物以及这些肽的药理学应用，特别是在治疗和预防癌症中。

公开(公告)号：US06613793B2

公开(公告)日：2003-09-02

申请号：US10187420

申请日：2002-07-01

申请人： Anand C. Burman ,  Rama Mukherjee ,  Manu Jaggi ,  Anu T. Singh ,  Kamal K. Kapoor ,  Sudhanand Prasad ,  Manju Ray

发明人： Anand C. Burman ,  Rama Mukherjee ,  Manu Jaggi ,  Anu T. Singh ,  Kamal K. Kapoor ,  Sudhanand Prasad ,  Manju Ray

IPC分类号： A61K3140

CPC分类号： C07D207/28

摘要： The invention relates to the use of imino acid conjugates of methylglyoxal for the inhibition and/or treatment of cancer. The invention relates more specifically to the use imino acid conjugates of methylglyoxal for inhibition and/or treatment of cancer of the Colon, Prostate, Larynx, Kidney, Pancreas, Lung, Breast, Intestine, Oral cavity, Ovary, Glioblastoma, and Leukemia. The invention also relates to compositions and methods of inhibiting cancer using imino acid conjugates of methylglyoxal.

摘要翻译： 本发明涉及甲基乙二醛的亚氨基酸偶联物用于抑制和/或治疗癌症的用途。 本发明更具体地涉及使用甲基乙二醛的亚氨基酸缀合物用于抑制和/或治疗结肠，前列腺，喉，肾，胰腺，肺，乳腺，肠，口腔，卵巢，成胶质细胞瘤和白血病的癌症。 本发明还涉及使用甲基乙二醛的亚氨基酸缀合物抑制癌症的组合物和方法。