-
公开(公告)号：US07094755B2
公开(公告)日：2006-08-22
申请号：US10254569
申请日：2002-09-25
申请人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Anu T. Singh , Archna Mathur , Neena Gupta
发明人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Anu T. Singh , Archna Mathur , Neena Gupta
IPC分类号： A61K38/16
CPC分类号： C07K14/57563 , A61K38/00 , Y10S930/17
摘要： The present invention encompasses novel analogs of vasoactive intestinal peptide (VIP), containing substitutions at appropriately selected amino acids. The invention particularly relates to the design and synthesis of novel biologically active VIP analogs containing α, α-dialkylated amino acids in a site-specific manner. Specifically, the invention relates to the synthesis of VIP peptide derivatives, which bind selectively to VIP receptors on target cells. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.
-
2.发明授权Polypeptides of covalently linked synthetic bioactive peptide analog(s) for treatment of cancer 失效共价连接的合成生物活性肽类似物用于治疗癌症的多肽公开(公告)号：US06949513B2
公开(公告)日：2005-09-27
申请号：US10186226
申请日：2002-06-28
申请人： Sudhanand Prasad , Rama Mukherjee , Anand C. Burman , Archna Mathur , Rajan Sharma , Manu Jaggi
发明人： Sudhanand Prasad , Rama Mukherjee , Anand C. Burman , Archna Mathur , Rajan Sharma , Manu Jaggi
IPC分类号： A61K38/00 , C07K14/575
CPC分类号： C07K14/575 , A61K38/00 , C07K2319/00
摘要： A polypeptide of the formula (I), Pa-L-Pb-L-Pc-L-Pd.
摘要翻译： 式（I）的多肽，<？in-line-formula description =“In-line Formulas”end =“lead”？> P -β-in-line-formula description =“In-line Formulas”end =“tail”？>
-
公开(公告)号：US06316414B1
公开(公告)日：2001-11-13
申请号：US09629371
申请日：2000-07-31
申请人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Archna Mathur
发明人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Archna Mathur
IPC分类号： A61K3800
CPC分类号： C07K14/6555 , A61K38/00
摘要： The present invention encompasses novel peptides that are agonists to somatostatin and the use of the agonists for treatment of cancer. The invention particularly relates to the design and synthesis of novel analogs of somatostatin incorporating &agr;, &agr;-dialkylated amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.
摘要翻译： 本发明包括作为促生长抑素激动剂的新型肽以及激动剂用于治疗癌症的用途。 本发明特别涉及以特异性位点结合α，α-二烷基化氨基酸的生长抑素的新型类似物的设计和合成。 本发明包括产生这些肽的方法，含有肽的组合物和这些肽的药理学应用，特别是在治疗和预防癌症中。
-
公开(公告)号：US06989371B1
公开(公告)日：2006-01-24
申请号：US09630333
申请日：2000-07-31
申请人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Archna Mathur
发明人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Archna Mathur
摘要： The present invention encompasses novel peptides that are antagonists to bombesin and bombesin like peptides and are useful in the treatment of cancer. The invention particularly relates to the design and synthesis of the novel peptides incorporating α,α-amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.
摘要翻译： 本发明包括作为铃蟾肽和铃蟾肽样肽的拮抗剂的新型肽，并且可用于治疗癌症。 本发明特别涉及以位点特异性方式结合α，α-氨基酸的新型肽的设计和合成。 本发明包括产生这些肽的方法，含有肽的组合物和这些肽的药理学应用，特别是在治疗和预防癌症中。
-
5.发明授权公开(公告)号：US07060678B2
公开(公告)日：2006-06-13
申请号：US10638107
申请日：2003-08-08
申请人： Sudhanand Prasad , Tushar Kanti Chakraborty , Archna Mathur , Manu Jaggi , Ajit Chand Kunwar , Rama Mukherjee , Anand C. Burman
发明人： Sudhanand Prasad , Tushar Kanti Chakraborty , Archna Mathur , Manu Jaggi , Ajit Chand Kunwar , Rama Mukherjee , Anand C. Burman
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1013 , C07K14/57563
摘要： Anticancer peptides which incorporate furanoid sugar amino acids and compositions made using these peptides are described. Methods for synthesis of the peptides and for preparing the furanoid sugar amino acids are disclosed. The peptides and compositions made using the peptides have pharmacological applications of these peptides especially in the treatment and prevention of cancer and tumors.
摘要翻译： 描述了掺入呋喃糖类氨基酸的抗癌肽和使用这些肽制备的组合物。 公开了合成肽和制备呋喃糖基氨基酸的方法。 使用肽制备的肽和组合物具有这些肽的药理学应用，特别是在治疗和预防癌症和肿瘤中。
-
6.发明申请Novel peptides comprising furanoid sugar amino acids for the treatment of cancer 失效包含呋喃糖类氨基酸的新型肽用于治疗癌症公开(公告)号：US20050032707A1
公开(公告)日：2005-02-10
申请号：US10638107
申请日：2003-08-08
申请人： Sudhanand Prasad , Tushar Chakraborty , Archna Mathur , Manu Jaggi , Ajit Kunwar , Rama Mukherjee , Anand Burman
发明人： Sudhanand Prasad , Tushar Chakraborty , Archna Mathur , Manu Jaggi , Ajit Kunwar , Rama Mukherjee , Anand Burman
IPC分类号： A61K38/00 , C07K5/103 , C07K7/06 , C07K14/575 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1013 , C07K14/57563
摘要： Anticancer peptides which incorporate furanoid sugar amino acids and compositions made using these peptides are described. Methods for synthesis of the peptides and for preparing the furanoid sugar amino acids are disclosed. The peptides and compositions made using the peptides have pharmacological applications of these peptides especially in the treatment and prevention of cancer and tumors.
摘要翻译： 描述了掺入呋喃糖类氨基酸的抗癌肽和使用这些肽制备的组合物。 公开了合成肽和制备呋喃糖基氨基酸的方法。 使用肽制备的肽和组合物具有这些肽的药理学应用，特别是在治疗和预防癌症和肿瘤中。
-
公开(公告)号：US06489297B1
公开(公告)日：2002-12-03
申请号：US09630335
申请日：2000-07-31
申请人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Anu T. Singh , Archna Mathur , Neena Gupta
发明人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Anu T. Singh , Archna Mathur , Neena Gupta
IPC分类号： A61K3816
CPC分类号： C07K14/57563 , A61K38/00 , Y10S930/17
摘要： The present invention encompasses novel analogs of vasoactive intestinal peptide (VIP), containing substitutions at appropriately selected amino acids. The invention particularly relates to the design and synthesis of novel biologically active VIP analogs containing &agr;,&agr;-dialkylated amino acids in a site-specific manner. Specifically, the invention relates to the synthesis of VIP peptide derivatives, which bind selectively to VIP receptors on target cells. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer,
摘要翻译： 本发明包括血管活性肠肽（VIP）的新类似物，其在适当选择的氨基酸处含有取代。 本发明特别涉及以位点特异性方式设计和合成含有α，α-二烷基化氨基酸的新型生物活性VIP类似物。 具体而言，本发明涉及VIP靶衍生物的合成，VIP衍生物选择性结合靶细胞上的VIP受体。 本发明包括产生这些肽的方法，含有肽的组合物和这些肽的药理学应用，特别是在治疗和预防癌症中，
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.01 秒)
