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1.Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl 失效
标题翻译: 制备(1R,2S,5S)-3-氮杂双环[3,1,0]己烷-2-甲酰胺,N- [3-氨基-1-(环丁基甲基)-2,3-二氧代丙基] -3 - [(2S)-2 - [[[1,1-二甲基乙基]氨基]羰基氨基] -3,3-二甲基-1-氧代丁基] -6,6-二甲基公开(公告)号:US07326795B2
公开(公告)日:2008-02-05
申请号:US10867600
申请日:2004-06-15
申请人: Anantha Sudhakar , Vilas Dahanukar , Ilia A. Zavialov , Cecilia Orr , Hoa N. Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael D. Green , George S. Wong , Jeonghan Park , Tetsuo Iwama
发明人: Anantha Sudhakar , Vilas Dahanukar , Ilia A. Zavialov , Cecilia Orr , Hoa N. Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael D. Green , George S. Wong , Jeonghan Park , Tetsuo Iwama
IPC分类号: C07D209/52 , C07C233/08
CPC分类号: C07K5/0202 , C07C271/22 , C07C2601/04
摘要: In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译: 在一个实施方案中,本申请涉及制备式I化合物的方法以及在制备式I化合物的方法中制备的某些中间体化合物。
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2.Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl 失效
标题翻译: 制备(1R,2S,5S)-3-氮杂双环[3,1,0]己烷-2-甲酰胺,N- [3-氨基-1-(环丁基甲基)-2,3-二氧代丙基] -3 - [(2S)-2 - [[[1,1-二甲基乙基]氨基]羰基氨基] -3,3-二甲基-1-氧代丁基] -6,6-二甲基公开(公告)号:US20050059800A1
公开(公告)日:2005-03-17
申请号:US10867600
申请日:2004-06-15
申请人: Anantha Sudhakar , Vilas Dahanukar , Ilia Zavialov , Cecilia Orr , Hoa Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael Green , George Wong , Jeonghan Park , Tetsuo Iwama
发明人: Anantha Sudhakar , Vilas Dahanukar , Ilia Zavialov , Cecilia Orr , Hoa Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael Green , George Wong , Jeonghan Park , Tetsuo Iwama
IPC分类号: C07C271/22 , C07K5/02 , C07K5/06
CPC分类号: C07K5/0202 , C07C271/22 , C07C2601/04
摘要: In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译: 在一个实施方案中,本申请涉及制备式I化合物的方法以及在制备式I化合物的方法中制备的某些中间体化合物。
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3.Process for preparing xanthine phosphodiesterase V inhibitors and precursers thereof 失效
标题翻译: 制备黄嘌呤磷酸二酯酶V抑制剂及其前体的方法公开(公告)号:US20060205943A1
公开(公告)日:2006-09-14
申请号:US11429719
申请日:2006-05-08
申请人: Vilas Dahanukar , Hoa Nguyen , Cecilia Orr , Fucheng Zhang , Ilia Zavialov
发明人: Vilas Dahanukar , Hoa Nguyen , Cecilia Orr , Fucheng Zhang , Ilia Zavialov
IPC分类号: C07D473/04 , C07D473/02
CPC分类号: C07C257/12 , C07D233/90 , C07D473/06
摘要: A process for preparing xanthine phosphodiesterase V inhibitors, and compounds utilized in said process. The process includes a five-step methodology for efficient synthesis of Compound 5 without intermediate purifications or separations, a dihalogenation step to synthesize Compound 7, and a coupling reaction to produce Compound 9.
摘要翻译: 一种制备黄嘌呤磷酸二酯酶V抑制剂的方法,以及用于所述方法的化合物。 该方法包括用于无中间纯化或分离的化合物5的有效合成的五步方法,合成化合物7的二卤化步骤和产生化合物9的偶联反应。
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