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![Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof](/abs-image/US/2009/08/04/US07569705B2/abs.jpg.150x150.jpg)
1.发明授权Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof 失效其制备用于其盐的（1R，2S，5S）-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸盐的方法和中间体公开(公告)号：US07569705B2
公开(公告)日：2009-08-04
申请号：US11982875
申请日：2007-11-06
申请人： Jeonghan Park , Anantha R Sudhakar , George S. K. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-long Kwok , Ingyu Jeon , Ramani R Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
发明人： Jeonghan Park , Anantha R Sudhakar , George S. K. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-long Kwok , Ingyu Jeon , Ramani R Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
IPC分类号： C07D209/52
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
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![Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof](/abs-image/US/2008/05/15/US20080114179A1/abs.jpg.150x150.jpg)
2.发明申请Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof 失效其制备用于其盐的（1R，2S，5S）-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸盐的方法和中间体公开(公告)号：US20080114179A1
公开(公告)日：2008-05-15
申请号：US11982875
申请日：2007-11-06
申请人： Jeonghan Park , Anantha Sudhakar , George Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw Kwok , Ingyu Jeon , Ramani Raghavan , Maria Tamarez , Weidong Tong , Eugene Vater
发明人： Jeonghan Park , Anantha Sudhakar , George Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw Kwok , Ingyu Jeon , Ramani Raghavan , Maria Tamarez , Weidong Tong , Eugene Vater
IPC分类号： C07C211/33 , C07C69/74 , C07C63/08 , C07D209/44
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
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![Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof](/abs-image/US/2007/12/18/US07309717B2/abs.jpg.150x150.jpg)
3.发明授权Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof 有权制备（1R，2S，5S）-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸盐或其盐的方法和中间体公开(公告)号：US07309717B2
公开(公告)日：2007-12-18
申请号：US10867602
申请日：2004-06-15
申请人： Jeonghan Park , Anantha Sudhakar , George S. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani R. Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
发明人： Jeonghan Park , Anantha Sudhakar , George S. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani R. Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
IPC分类号： A61K31/21 , C07D209/52
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
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![Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof](/abs-image/US/2005/03/17/US20050059648A1/abs.jpg.150x150.jpg)
4.发明申请Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof 有权制备（1R，2S，5S）-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸盐或其盐的方法和中间体公开(公告)号：US20050059648A1
公开(公告)日：2005-03-17
申请号：US10867602
申请日：2004-06-15
申请人： Jeonghan Park , Anantha Sudhakar , George Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani Raghavan , Maria Tamarez , Weidong Tong , Eugene Vater
发明人： Jeonghan Park , Anantha Sudhakar , George Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani Raghavan , Maria Tamarez , Weidong Tong , Eugene Vater
IPC分类号： C07C69/74 , C07C215/20 , C07C233/58 , C07C271/18 , C07D209/52 , A61K31/33
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
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公开(公告)号：US20150329521A1
公开(公告)日：2015-11-19
申请号：US14649837
申请日：2013-12-04
申请人： Tetsuji ITOH , Ingyu JEON , Ian MANGION , Gang QIAN , Benjamin D. SHERRY , Donald R. GAUTHIER , Yang CAO , MERCK SHARP & DOHME CORP.
发明人： Tetsuji Itoh , Ingyu Jeon , Ian Mangion , Gang QIAN , Benjamin D. Sherry , Donald R. Gauthier , Yang CAO
IPC分类号： C07D401/06
CPC分类号： C07D401/06
摘要： The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase, HIV replication and the treatment of human immunodeficiency virus infection in humans.
摘要翻译： 本发明涉及一种合成3-（取代的苯氧基）-1 - [（5-氧代-4,5-二氢-1H-1,2,4-三唑-3-基）甲基]] - 吡啶-2（1H） - 酮衍生物。 通过本发明的方法合成的化合物是可用于抑制逆转录酶，HIV复制和人类免疫缺陷病毒感染治疗的HIV逆转录酶抑制剂。
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![Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl](/abs-image/US/2008/02/05/US07326795B2/abs.jpg.150x150.jpg)
6.发明授权Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl 失效制备（1R，2S，5S）-3-氮杂双环[3,1,0]己烷-2-甲酰胺，N- [3-氨基-1-（环丁基甲基）-2,3-二氧代丙基] -3 - [（2S）-2 - [[[1,1-二甲基乙基]氨基]羰基氨基] -3,3-二甲基-1-氧代丁基] -6,6-二甲基公开(公告)号：US07326795B2
公开(公告)日：2008-02-05
申请号：US10867600
申请日：2004-06-15
申请人： Anantha Sudhakar , Vilas Dahanukar , Ilia A. Zavialov , Cecilia Orr , Hoa N. Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael D. Green , George S. Wong , Jeonghan Park , Tetsuo Iwama
发明人： Anantha Sudhakar , Vilas Dahanukar , Ilia A. Zavialov , Cecilia Orr , Hoa N. Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael D. Green , George S. Wong , Jeonghan Park , Tetsuo Iwama
IPC分类号： C07D209/52 , C07C233/08
CPC分类号： C07K5/0202 , C07C271/22 , C07C2601/04
摘要： In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物的方法以及在制备式I化合物的方法中制备的某些中间体化合物。
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![Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl](/abs-image/US/2005/03/17/US20050059800A1/abs.jpg.150x150.jpg)
7.发明申请Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl 失效制备（1R，2S，5S）-3-氮杂双环[3,1,0]己烷-2-甲酰胺，N- [3-氨基-1-（环丁基甲基）-2,3-二氧代丙基] -3 - [（2S）-2 - [[[1,1-二甲基乙基]氨基]羰基氨基] -3,3-二甲基-1-氧代丁基] -6,6-二甲基公开(公告)号：US20050059800A1
公开(公告)日：2005-03-17
申请号：US10867600
申请日：2004-06-15
申请人： Anantha Sudhakar , Vilas Dahanukar , Ilia Zavialov , Cecilia Orr , Hoa Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael Green , George Wong , Jeonghan Park , Tetsuo Iwama
发明人： Anantha Sudhakar , Vilas Dahanukar , Ilia Zavialov , Cecilia Orr , Hoa Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael Green , George Wong , Jeonghan Park , Tetsuo Iwama
IPC分类号： C07C271/22 , C07K5/02 , C07K5/06
CPC分类号： C07K5/0202 , C07C271/22 , C07C2601/04
摘要： In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物的方法以及在制备式I化合物的方法中制备的某些中间体化合物。
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![Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof](/abs-image/US/2010/06/01/US07728165B2/abs.jpg.150x150.jpg)
8.发明授权Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof 失效制备（1R，2S，5S）-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸盐或其盐的方法和中间体公开(公告)号：US07728165B2
公开(公告)日：2010-06-01
申请号：US12484461
申请日：2009-06-15
申请人： Jeonghan Park , Anantha R Sudhakar , George S. K. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-long Kwok , Ingyu Jeon , Ramani R Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
发明人： Jeonghan Park , Anantha R Sudhakar , George S. K. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-long Kwok , Ingyu Jeon , Ramani R Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
IPC分类号： C07C69/01 , C07C211/17 , C07C235/02
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
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![PROCESS AND INTERMEDIATES FOR THE PREPARATION OF (1R,2S,5S)-6,6-DIMETHYL-3-AZABICYCLO[3,1,0]HEXANE-2-CARBOXYLATES OR SALTS THEREOF](/abs-image/US/2009/10/01/US20090247784A1/abs.jpg.150x150.jpg)
9.发明申请PROCESS AND INTERMEDIATES FOR THE PREPARATION OF (1R,2S,5S)-6,6-DIMETHYL-3-AZABICYCLO[3,1,0]HEXANE-2-CARBOXYLATES OR SALTS THEREOF 失效（1R，2S，5S）-6,6-二甲基-3-亚氨基] [3,1,0]庚烷-2-羧酸酯或其盐的制备方法和中间体公开(公告)号：US20090247784A1
公开(公告)日：2009-10-01
申请号：US12484461
申请日：2009-06-15
申请人： Jeonghan Park , Anantha R. Sudhakar , George S. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani R. Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
发明人： Jeonghan Park , Anantha R. Sudhakar , George S. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani R. Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
IPC分类号： C07C61/04 , C07C229/38
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
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