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81 条记录 (耗时 0.033 秒)

    Quantitative diagnostic analysis of hypertonia
    1.
    发明申请
    Quantitative diagnostic analysis of hypertonia 审中-公开
    高血压的定量诊断分析

    公开(公告)号：US20060127892A1

    公开(公告)日：2006-06-15

    申请号：US10472622

    申请日：2002-03-21

    申请人： Andreas Busjahn ,  Friedrich Luft ,  Florian Lang

    发明人： Andreas Busjahn ,  Friedrich Luft ,  Florian Lang

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/566 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N2333/723

    摘要： The invention relates to the application of the direct correlation between the overexpression or the functional molecular modification of human homologs of the sgk family and hypertension for quantitative diagnosis of a particular form of genetically determined hypertension. In particular the invention relates to the detection of a direct link between two different polymorphisms of individual nucleotides in the hsgk1 gene and the genetically determined predisposition to hypertension. The invention further relates to the provision of a diagnostic kit containing antibodies or polynucleotides for detecting the diagnostic targets hsgk1, hsgk2 and hsgk3.

    摘要翻译： 本发明涉及在sgk家族的人类同源物的高表达或功能性分子修饰与高血压之间的直接相关性的应用，用于定量诊断特定形式的遗传确定的高血压。 特别地，本发明涉及检测hsgk1基因中各个核苷酸的两种不同多态性与遗传上确定的高血压倾向之间的直接联系。 本发明还涉及提供包含用于检测诊断靶标hsgk1，hsgk2和hsgk3的抗体或多核苷酸的诊断试剂盒。

    Use of a Novel Polymorphism in the Hsgk1 Gene in the Diagnosis of Hypertonia an Use of the Sgk Gene Family in the Diagnosis and Therapy of the Long Qt Syndrome
    2.
    发明申请
    Use of a Novel Polymorphism in the Hsgk1 Gene in the Diagnosis of Hypertonia an Use of the Sgk Gene Family in the Diagnosis and Therapy of the Long Qt Syndrome 审中-公开
    在高血压诊断中使用Hsgk1基因中的新型多态性使用Sgk基因家族进行长Qt综合征的诊断和治疗

    公开(公告)号：US20080015141A1

    公开(公告)日：2008-01-17

    申请号：US10544576

    申请日：2004-02-05

    申请人： Florian Lang ,  Andreas Busjahn

    发明人： Florian Lang ,  Andreas Busjahn

    IPC分类号： A61K38/16 ,  A61K31/56 ,  C12Q1/68 ,  G01N33/00

    CPC分类号： A61K31/573 ,  A61K31/56 ,  A61K38/1841 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/573 ,  G01N33/6893 ,  G01N2333/9121

    摘要： The invention relates to the use of a single-stranded or double-stranded nucleic acid comprising a fragment of hsgk for diagnosing hypertension, with said fragment being at least 10 nucleotides/base pairs in length and with said fragment furthermore comprising a polymorphism with ensues from the presence or absence of an insertion of the nucleotide G at position 732/733 in intron 2 of the hsgk1 gene. The invention furthermore relates to the use of the direct correlation between the overexpression or the functional molecular modification of human homologues of the sgk family and the length of the Q/T interval for diagnosing the long Q/T syndrome, and also to the use for the nucleic acid of a human homologue of the sgk gene family or of one of its fragments for diagnosing the long Q/T syndrome. In particular, polymorphisms of individual nucleotides (single nucleotide polymorphisms=SNP) in the human homologues of the sgk gene family can also, in the present case, be used for diagnosing a genetically determined predisposition for the long Q/T syndrome. In a further aspect, the invention relates to the use of a functional activator or transcription factor which increases the expression of the genes of the sgk family for producing a pharmaceutical for the therapy and/or prophylaxis of the long Q/T syndrome.

    摘要翻译： 本发明涉及包含hsgk片段的单链或双链核酸用于诊断高血压的用途，所述片段长度为至少10个核苷酸/碱基对，并且所述片段还包含多态性，随后来自 存在或不存在hsgk1基因的内含子2中位置732/733处的核苷酸G的插入。 本发明还涉及使用sgk家族的人类同源物的过表达或功能性分子修饰与用于诊断长Q / T综合征的Q / T间期的长度之间的直接相关性，以及用于 用于诊断长Q / T综合征的sgk基因家族的人类同源物的核酸或其片段之一的核酸。 特别地，在sgk基因家族的人类同源物中，单个核苷酸的多态性（ single 核苷酸多态性= SNP） 在这种情况下，用于诊断长期Q / T综合征的遗传决定性倾向。 在另一方面，本发明涉及功能活化剂或转录因子的用途，其增加sgk家族的基因的表达以产生用于治疗和/或预防长Q / T综合征的药物。

    SGK1 AS DIAGNOSTIC AND THERAPEUTIC TARGET
    3.
    发明申请
    SGK1 AS DIAGNOSTIC AND THERAPEUTIC TARGET 审中-公开
    SGK1作为诊断和治疗目标

    公开(公告)号：US20120149765A1

    公开(公告)日：2012-06-14

    申请号：US13315850

    申请日：2011-12-09

    申请人： Florian Lang

    发明人： Florian Lang

    IPC分类号： A61K31/7088 ,  C12Q1/68 ,  C07K16/40 ,  A61K31/473 ,  A61P9/12 ,  G01N33/566 ,  A61K31/553

    CPC分类号： C12Q1/485

    摘要： The invention relates to the utilization of a substance for diagnostic determination of sgk1 (serum and glucocorticoid dependent kinase 1) and to the utilization of an active agent in order to influence sgk1 for therapeutic treatment of diseases associated with disordered activity of the tissue factor and to a diagnostic kit related to such substances or such active agents.

    摘要翻译： 本发明涉及用于sgk1（血清和糖皮质激素依赖性激酶1）的诊断测定的物质的利用和活性剂的利用，以影响sgk1用于治疗与组织因子的无序活性相关的疾病的治疗，以及 与这些物质或这种活性剂相关的诊断试剂盒。

    Mandelic hydrazides
    7.
    发明授权
    Mandelic hydrazides 失效
    扁豆酰肼

    公开(公告)号：US07776920B2

    公开(公告)日：2010-08-17

    申请号：US12279227

    申请日：2007-01-18

    申请人： Rolf Gericke ,  Markus Klein ,  Werner Mederski ,  Norbert Beier ,  Florian Lang

    发明人： Rolf Gericke ,  Markus Klein ,  Werner Mederski ,  Norbert Beier ,  Florian Lang

    IPC分类号： C07C243/38 ,  A61K31/166

    CPC分类号： C07C243/38

    摘要： Novel mandelic hydrazides of the formula (I), in which R1-R11 have the meanings indicated in claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and complaints, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in fibroses and inflammatory processes of any type.

    摘要翻译： 式（I）的新型扁桃酸酰肼，其中R 1 -R 11具有权利要求1所述的含义，是SGK抑制剂，可用于治疗SGK诱发的疾病和投诉，例如糖尿病，肥胖症，代谢综合征 血脂异常），全身和肺高血压，心血管疾病和肾脏疾病，通常在任何类型的纤维和炎症过程中。

    Strap for snowboard boots or bindings
    8.
    发明授权
    Strap for snowboard boots or bindings 有权

    公开(公告)号：US07766364B2

    公开(公告)日：2010-08-03

    申请号：US12392583

    申请日：2009-02-25

    申请人： Christopher C. Cunningham ,  Christopher M. Doyle ,  Gregory Aaron Dean ,  Florian Lang ,  Scott T. Keller ,  Matt Windt

    发明人： Christopher C. Cunningham ,  Christopher M. Doyle ,  Gregory Aaron Dean ,  Florian Lang ,  Scott T. Keller ,  Matt Windt

    IPC分类号： A63C9/00 ,  A63C9/06

    CPC分类号： A43C11/146 ,  A63C10/06 ,  A63C10/24

    摘要： A binding or boot strap is provided that allows a rider to easily, rapidly and/or effectively tighten and/or loosen the strap about his or her boot. The strap includes a boot-engaging strap portion that engages with an engagement strap coupleable to the boot, as may be the case with boots used for step-in bindings, or to the binding, as may be the case with strap-type bindings. An arrangement for facilitating tightening/loosening of the two strap pieces so that a rider can slip his or her foot into or out from the boot or fasten the boot to or loosen it from a snowboard binding is also provided. In one embodiment, this arrangement includes a tightening element, such as for example a cord, lace or strap, suitably coupled to one or both strap portions such that a rider can pull on the tightening element to move the strap pieces relative to each other and tighten the strap. The tightening arrangement may be configured with a mechanical advantage whereby the force applied to the tightening element results in a greater force applied to the strap. To take up any excess amount of tightening element after the strap has been tightened, a retraction device, such as a self-winding spool, may be utilized. To separate the strap from the boot or binding, a hook and catch arrangement may be employed.

    LACE SYSTEM FOR FOOTWEAR
    10.
    发明申请
    LACE SYSTEM FOR FOOTWEAR 审中-公开
    鞋类系统

    公开(公告)号：US20090019734A1

    公开(公告)日：2009-01-22

    申请号：US12233070

    申请日：2008-09-18

    申请人： Greg Reagan ,  Christopher M. Doyle ,  Florian Lang ,  Maurizio Molin

    发明人： Greg Reagan ,  Christopher M. Doyle ,  Florian Lang ,  Maurizio Molin

    IPC分类号： A43B5/04

    CPC分类号： A43C1/003 ,  A43B3/0031 ,  A43B11/00 ,  A43C1/06 ,  A43C3/00 ,  A43C7/00 ,  A43C11/008 ,  A43C11/14

    摘要： A snowboard boot incorporating techniques for making the process of tightening and loosening the laces of a snowboard boot more convenient for the wearer is disclosed. The snowboard boot may be provided with at least two independent lacing zones, the tensions of which are separately adjustable by the wearer. The zones may be secured by pulling on two laces, each of which tightens one of the two independent lacing zones. This arrangement allows the wearer to simultaneously tighten each zone, providing the wearer with the “feel” as though he or she is tightening a conventional single lacing zone snowboard boot. The laces may be simultaneously, yet independently secured by a lace lock at the upper and/or forward region of the snowboard boot. Slack may be created to facilitate loosening of the snowboard boot and easy removal of a foot from the snowboard boot by unhooking the lace from the lace guide without a corresponding distance of lace traveling through the lace lock. A release strap, graspable by the wearer, facilitates unhooking the lace.

    摘要翻译： 公开了一种包含用于使紧固和松动对于穿着者更方便的滑雪板护套的鞋带的过程的滑雪靴。 滑雪靴可以设置有至少两个独立的鞋带区，其张力可由穿着者单独调节。 这些区域可以通过拉两个鞋带来固定，每个鞋带收紧两个独立鞋带区中的一个。 这种布置允许佩戴者同时收紧每个区域，为佩戴者提供“感觉”，就好像他或她正在收紧传统的单一系带区滑雪靴。 鞋带可以同时地，但是通过在滑雪板靴的上部和/或前部区域处的花边锁独立地固定。 可以创建松弛以便于滑雪靴的松动，并且通过从蕾丝引导件脱钩花边而不使蕾丝行进通过花边锁的相应距离，从而容易地从雪靴靴中移除脚。 由佩戴者掌握的释放带有助于脱钩蕾丝。