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10 条记录 (耗时 0.011 秒)

    Use of haplotypes and SNPs in lipid-relevant genes for the analysis and diagnosis of cardiovascular disease
    4.
    发明申请
    Use of haplotypes and SNPs in lipid-relevant genes for the analysis and diagnosis of cardiovascular disease 审中-公开
    在脂质相关基因中使用单体型和SNP进行心血管疾病的分析和诊断

    公开(公告)号：US20050196794A1

    公开(公告)日：2005-09-08

    申请号：US11061562

    申请日：2005-02-18

    申请人： Peter Nurnberg ,  Jens-Georg Reich ,  Friedrich Luft ,  Hans Knoblauch ,  Anja Bauerfeind ,  Tatjana Luganskaja ,  Klaus Rohde

    发明人： Peter Nurnberg ,  Jens-Georg Reich ,  Friedrich Luft ,  Hans Knoblauch ,  Anja Bauerfeind ,  Tatjana Luganskaja ,  Klaus Rohde

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156

    摘要： The present invention relates to an in vitro method for diagnosing a genetic predisposition or susceptibility for a cardiovascular disease, condition or disorder in a mammal which comprises detecting of at least three particular single nucleotide polymorphisms (SNP) in a sample obtained from said mammal in at least one of a genomic locus-derived nucleic acid or fragment thereof of the loci APOB, APOE, ABCA1, CETP, LCAT, LIPC, LPL, LDLR, APOC2, APOA5, APOA4, APOC3, and APOA1. Furthermore, the present invention relates to the improved diagnosis that is based on the analysis of several haplotypes for the above-mentioned loci (i.e. a combination of said haplotypes).

    摘要翻译： 本发明涉及用于诊断哺乳动物心血管疾病，病症或病症的遗传易感性或易感性的体外方法，其包括在所述哺乳动物获得的样品中检测至少三种特定单核苷酸多态性（SNP） 位点APOB，APOE，ABCA1，CETP，LCAT，LIPC，LPL，LDLR，APOC2，APOA5，APOA4，APOC3和APOA1的基因组座标衍生的核酸或其片段中的至少一种。 此外，本发明涉及基于对上述位点的几种单元型（即所述单元型的组合）的分析的改进的诊断。

    Device for the nondispersive infrared gas analysis
    5.
    发明授权
    Device for the nondispersive infrared gas analysis 失效
    不间断红外分析的装置

    公开(公告)号：US3700891A

    公开(公告)日：1972-10-24

    申请号：US3700891D

    申请日：1971-05-12

    申请人： KARL FRIEDRICH LUFT

    发明人： LUFT KARL FRIEDRICH

    IPC分类号： G01N21/37 ,  G01N21/26

    CPC分类号： G01N21/37

    摘要： This invention comprises a device for detecting and measuring a gas component of a gas mixture using the optical-pneumatic effect produced by absorption of infrared radiation by a gas. The device comprises, in optical alignment, a radiation source, filter means, a cuvette system and a receiver unit which contains a measuring chamber and a comparison chamber. Pressure differential means such as a diaphragm condenser measures the opticalpneumatic effect produced by the absorption of radiation. The device is provided with porous means for flow of gases to eliminate interfering fluctuations in gas flow.

    摘要翻译： 本发明包括一种使用由气体吸收红外辐射产生的光学 - 气动效应来检测和测量气体混合物的气体成分的装置。 该装置在光学对准中包括辐射源，过滤装置，比色皿系统和包含测量室和比较室的接收器单元。 诸如隔膜冷凝器的压差装置测量由吸收辐射产生的光学 - 气动效应。 该装置设有用于气体流动的多孔装置，以消除气流中的干扰波动。

    Non-dispersive infrared gas analysis device with triple layer receiver
    7.
    发明授权
    Non-dispersive infrared gas analysis device with triple layer receiver 失效
    具有三层接收器的非分散红外线气体分析装置

    公开(公告)号：US3968369A

    公开(公告)日：1976-07-06

    申请号：US524249

    申请日：1974-11-15

    申请人： Karl Friedrich Luft

    发明人： Karl Friedrich Luft

    IPC分类号： G01N21/37 ,  G01N21/26

    CPC分类号： G01N21/37

    摘要： A radiation receiver including three receiver layers for infrared gas analysis. The first and third layers are connected in parallel, and their pressure is compared with that of the second or middle layer to derive a pressure difference which compensates for certain measurement problems found in prior art devices.

    摘要翻译： 一种辐射接收器，包括用于红外气体分析的三个接收层。 第一和第三层并联连接，并将它们的压力与第二层或第二层的压力进行比较，以得出压力差，该压力差补偿现有技术装置中发现的某些测量问题。

    Quantitative diagnostic analysis of hypertonia
    8.
    发明申请
    Quantitative diagnostic analysis of hypertonia 审中-公开
    高血压的定量诊断分析

    公开(公告)号：US20060127892A1

    公开(公告)日：2006-06-15

    申请号：US10472622

    申请日：2002-03-21

    申请人： Andreas Busjahn ,  Friedrich Luft ,  Florian Lang

    发明人： Andreas Busjahn ,  Friedrich Luft ,  Florian Lang

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/566 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N2333/723

    摘要： The invention relates to the application of the direct correlation between the overexpression or the functional molecular modification of human homologs of the sgk family and hypertension for quantitative diagnosis of a particular form of genetically determined hypertension. In particular the invention relates to the detection of a direct link between two different polymorphisms of individual nucleotides in the hsgk1 gene and the genetically determined predisposition to hypertension. The invention further relates to the provision of a diagnostic kit containing antibodies or polynucleotides for detecting the diagnostic targets hsgk1, hsgk2 and hsgk3.

    摘要翻译： 本发明涉及在sgk家族的人类同源物的高表达或功能性分子修饰与高血压之间的直接相关性的应用，用于定量诊断特定形式的遗传确定的高血压。 特别地，本发明涉及检测hsgk1基因中各个核苷酸的两种不同多态性与遗传上确定的高血压倾向之间的直接联系。 本发明还涉及提供包含用于检测诊断靶标hsgk1，hsgk2和hsgk3的抗体或多核苷酸的诊断试剂盒。

    Non-dispersive infrared gas analyzer
    9.
    发明授权
    Non-dispersive infrared gas analyzer 失效
    非分散型红外线气体分析仪

    公开(公告)号：US3968370A

    公开(公告)日：1976-07-06

    申请号：US536332

    申请日：1974-12-26

    申请人： Karl Friedrich Luft

    发明人： Karl Friedrich Luft

    IPC分类号： G01N21/61 ,  G01N21/37 ,  G01J1/00

    CPC分类号： G01N21/37 ,  G01N21/61

    摘要： An auxiliary signal for the compensation of the difference signal created in optical-pneumatic receivers due to the absorption of radiation, such compensation being achieved by one or more electrical-pneumatic transmitters connected directly to the receiver chambers.

    摘要翻译： 用于补偿由于吸收辐射而在光学气动接收器中产生的差分信号的辅助信号，这种补偿由一个或多个直接连接到接收器室的电动气动发射器实现。

    Peptides of the AT1 receptor and their uses
    10.
    发明授权
    Peptides of the AT1 receptor and their uses 失效
    AT1受体的肽及其用途

    公开(公告)号：US07745139B1

    公开(公告)日：2010-06-29

    申请号：US09868967

    申请日：1999-12-22

    申请人： Gerd Wallukat ,  Volker Homuth ,  Friedrich Luft

    发明人： Gerd Wallukat ,  Volker Homuth ,  Friedrich Luft

    IPC分类号： G01N33/53 ,  C07K4/00 ,  C07K4/12 ,  C07K16/28

    CPC分类号： A61K39/0008 ,  A61K38/00 ,  A61K39/00 ,  C07K14/70571

    摘要： Disclosed are peptides of the AT1 receptor and their use for eliminating specifically binding, cell-physiologically active, pathological antibodies in preeclampsia and malign hypertension. The peptides may, for example, be used for the diagnosis of preeclampsia. Peptides having the sequence AFHYESQ (SEQ ID NO: 1), AVHYQSN (SEQ ID NO: 2), SHFYQTR (SEQ ID NO: 3), GYYFDTN (SEQ ID NO: 4) or ENTNIT (SEQ ID NO: 5) are preferred.

    摘要翻译： 公开了AT1受体的肽及其在先兆子痫和恶性高血压中消除特异性结合的，细胞 - 生理活性的病理学抗体的用途。 肽可以例如用于先兆子痫的诊断。 具有序列AFHYESQ（SEQ ID NO：1），AVHYQSN（SEQ ID NO：2），SHFYQTR（SEQ ID NO：3），GYYFDTN（SEQ ID NO：4）或ENTNIT（SEQ ID NO：5）的肽是优选的 。