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公开(公告)号：US20050085409A1
公开(公告)日：2005-04-21
申请号：US10753757
申请日：2004-01-07
CPC分类号： B01J2/04 , B01D11/0403 , B01D11/0407 , B01D11/0411 , B01D11/0473 , B01D11/0484
摘要： Method for preparing a target substance in particulate form, by introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a solution or suspension of the target substance in a fluid vehicle (the “target solution/suspension”) and (b) a compressed fluid anti-solvent for the substance, and allowing the anti-solvent to extract the vehicle from the target solution/suspension so as to form particles of the target substance, wherein the target solution/suspension enters the vessel downstream of the point of entry of the anti-solvent and at a point which lies on or close to the main axis of anti-solvent flow, and wherein the anti-solvent has a sub-sonic velocity as it enters the particle formation vessel.
摘要翻译： 通过分别通过分开的第一和第二流体入口引入颗粒形成容器，（a）目标物质在流体载体中的溶液或悬浮液（“目标溶液/悬浮液”）的制备方法， ）和（b）用于该物质的压缩流体抗溶剂，并且允许反溶剂从目标溶液/悬浮液中提取载体以形成目标物质的颗粒，其中目标溶液/悬浮液进入容器 在反溶剂进入点的下游，位于或接近反溶剂流动主轴线的点处，并且其中反溶剂在其进入颗粒形成容器时具有次声速度。
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公开(公告)号：US07087197B2
公开(公告)日：2006-08-08
申请号：US10197689
申请日：2002-07-17
IPC分类号： B29B9/00
CPC分类号： B01J2/04
摘要： Method for preparing a target substance in particulate form, comprising introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a “target solution/suspension” of the substance in a fluid vehicle and (b) a compressed fluid anti-solvent, and allowing the anti-solvent to extract the vehicle so as to form particles of the substance, wherein the anti-solvent fluid has a sonic, near-sonic or supersonic velocity as it enters the vessel, and wherein the anti-solvent and the target solution/suspension enter the vessel at different locations and meet downstream (in the direction of anti-solvent flow) of the second fluid inlet. Also provided is apparatus for use in such a method.
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公开(公告)号：US20060280823A1
公开(公告)日：2006-12-14
申请号：US11416641
申请日：2006-05-03
IPC分类号： B29B9/00
CPC分类号： B01J2/04
摘要： Method for preparing a target substance in particulate form, comprising introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a “target solution/suspension” of the substance in a fluid vehicle and (b) a compressed fluid anti-solvent, and allowing the anti-solvent to extract the vehicle so as to form particles of the substance, wherein the anti-solvent fluid has a sonic, near-sonic or supersonic velocity as it enters the vessel, and wherein the anti-solvent and the target solution/suspension enter the vessel at different locations and meet downstream (in the direction of anti-solvent flow) of the second fluid inlet. Also provided is apparatus for use in such a method.
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公开(公告)号：US20060279011A1
公开(公告)日：2006-12-14
申请号：US11416640
申请日：2006-05-03
IPC分类号： B29B9/00
CPC分类号： B01J2/04
摘要： Method for preparing a target substance in particulate form, comprising introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a “target solution/suspension” of the substance in a fluid vehicle and (b) a compressed fluid anti-solvent, and allowing the anti-solvent to extract the vehicle so as to form particles of the substance, wherein the anti-solvent fluid has a sonic, near-sonic or supersonic velocity as it enters the vessel, and wherein the anti-solvent and the target solution/suspension enter the vessel at different locations and meet downstream (in the direction of anti-solvent flow) of the second fluid inlet. Also provided is apparatus for use in such a method.
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