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![Pyrido [5, 4-D] pyrimidines as cell proliferation inhibitors](/abs-image/US/2014/02/18/US08653087B2/abs.jpg.150x150.jpg)
公开(公告)号：US08653087B2
公开(公告)日：2014-02-18
申请号：US13062058
申请日：2009-09-08
申请人： Andreas Mantoulidis , Georg Dahmann , Peter Ettmayer , Christian Klein , Steffen Steurer , Irene Waizenegger , Stephan Karl Zahn
发明人： Andreas Mantoulidis , Georg Dahmann , Peter Ettmayer , Christian Klein , Steffen Steurer , Irene Waizenegger , Stephan Karl Zahn
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, X1, X2, X3, L1 and L2 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or anomalous cell proliferation, and the use thereof in such a treatment.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 4，X 1，X 2，X 3，L 1和L 2基团如权利要求1中所定义，其适用于治疗以过度或异常细胞增殖为特征的疾病， 及其在这种治疗中的用途。
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![PYRIDO [5, 4-D] PYRIMIDINES AS CELL PROLIFERATION INHIBITORS](/abs-image/US/2012/04/19/US20120094975A1/abs.jpg.150x150.jpg)
2.发明申请公开(公告)号：US20120094975A1
公开(公告)日：2012-04-19
申请号：US13062058
申请日：2009-09-08
申请人： Andreas Mantoulidis , Georg Dahmann , Peter Ettmayer , Christian Klein , Steffen Steurer , Irene Waizenegger , Stephan Karl Zahn
发明人： Andreas Mantoulidis , Georg Dahmann , Peter Ettmayer , Christian Klein , Steffen Steurer , Irene Waizenegger , Stephan Karl Zahn
IPC分类号： A61K31/519 , C07D487/10 , A61K31/55 , A61K31/551 , A61P31/00 , A61K31/541 , A61K31/5377 , A61P35/00 , A61P29/00 , A61P37/00 , C07D487/04 , A61K31/553
CPC分类号： C07D487/04
摘要： The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, X1, X1, X3, L1 and L2 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell pro-liferation, and the use thereof in such a treatment.
摘要翻译： 本发明包括通式（1）的化合物，其中基团R1至R4，X1，X1，X3，L1和L2如权利要求1中所定义，其适用于治疗特征在于过度或异常的细胞因子 并且在这种治疗中使用它们。
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公开(公告)号：US20110183952A1
公开(公告)日：2011-07-28
申请号：US12665769
申请日：2008-07-01
申请人： Ioannis Sapountzis , Peter Ettmayer , Christian Klein , Andreas Mantoulidis , Steffen Steurer , Irene Waizenegger
发明人： Ioannis Sapountzis , Peter Ettmayer , Christian Klein , Andreas Mantoulidis , Steffen Steurer , Irene Waizenegger
IPC分类号： A61K31/397 , C07D401/14 , C07D413/14 , C07D249/04 , C07D403/14 , C07D243/08 , A61K31/4439 , A61K31/5377 , A61K31/4192 , A61K31/497 , A61K31/55 , A61K31/551 , A61P35/00 , A61P37/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D487/08
摘要： The present invention encompasses compounds of general formula (1), wherein the groups R1 to R3 and L are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3和L基团如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用于制备药物 具有上述性质。
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公开(公告)号：US08889665B2
公开(公告)日：2014-11-18
申请号：US12665769
申请日：2008-07-01
申请人： Ioannis Sapountzis , Peter Ettmayer , Christian Klein , Andreas Mantoulidis , Steffen Steurer , Irene Waizenegger
发明人： Ioannis Sapountzis , Peter Ettmayer , Christian Klein , Andreas Mantoulidis , Steffen Steurer , Irene Waizenegger
IPC分类号： A61K31/55 , A61K31/535 , A61K31/497 , A61K31/44 , A61K31/415 , C07D403/04 , C07D401/14 , C07D403/14 , C07D417/04 , C07D487/08 , C07D417/14 , C07D401/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/04 , C07D417/14 , C07D487/08
摘要： The present invention encompasses compounds of general formula (1), wherein the groups R1 to R3 and L are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3和L基团如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用于制备药物 具有上述性质。
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公开(公告)号：US20100240657A1
公开(公告)日：2010-09-23
申请号：US12665776
申请日：2008-07-01
申请人： Ioannis Sapountzis , Peter Ettmayer , Christian Klein , Andreas Mantoulidis , Martin Steegmaier , Steffen Steurer , Irene Waizenegger
发明人： Ioannis Sapountzis , Peter Ettmayer , Christian Klein , Andreas Mantoulidis , Martin Steegmaier , Steffen Steurer , Irene Waizenegger
IPC分类号： A61K31/5377 , C07C63/64 , A61K31/192 , C07D401/04 , A61K31/4439 , C07D277/22 , A61K31/427 , C07D263/32 , A61K31/422 , C07D249/06 , A61K31/4196 , C07D403/04 , A61K31/506 , C07D471/04 , A61K31/437 , C07C307/02 , A61K31/18 , C07D413/14 , A61K31/497 , C07C69/78 , A61K31/235 , A61P35/00 , A61P29/00 , A61P37/00
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/04
摘要： The present invention encompasses compounds of general formula (1) wherein the groups R2 to R4, L, Q and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 2至R 4，L，Q和n基团如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 制备具有上述性质的药物组合物。
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公开(公告)号：US08198308B2
公开(公告)日：2012-06-12
申请号：US12946069
申请日：2010-11-15
申请人： Steffen Steurer , Peter Ettmayer , Andreas Mantoulidis , Ioannis Sapountzis , Martin Steegmaier
发明人： Steffen Steurer , Peter Ettmayer , Andreas Mantoulidis , Ioannis Sapountzis , Martin Steegmaier
IPC分类号： A61K31/44 , C07D401/00
CPC分类号： C07D417/14 , C07D401/12 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14
摘要： The present invention encompasses compounds of general formula (1) wherein the groups R2 to R4, L, Q and n are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 2至R 4，L，Q和n基团如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用途 用于制备具有上述性质的药物。
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公开(公告)号：US20130190286A1
公开(公告)日：2013-07-25
申请号：US13636157
申请日：2011-03-25
IPC分类号： C07D487/10 , A61K31/496 , A61K45/06 , A61K31/551 , A61K31/4439 , A61K31/4545 , A61K31/5377 , A61K31/553 , C07D413/14 , C07D401/14
CPC分类号： C07D487/10 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K31/553 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention encompasses compounds of general formula (1) where in the groups R0to R3 and L are defined as in claim 1, which are suitable for the 5 treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.
摘要翻译： 本发明包括通式（1）的化合物，其中R 0至R 3和L的基团如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病的治疗，其含有该化合物的药物 善良和用作药物。
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公开(公告)号：US09290507B2
公开(公告)日：2016-03-22
申请号：US13636157
申请日：2011-03-25
IPC分类号： C07D487/10 , C07D413/14 , A61K31/496 , C07D401/14 , A61K31/4439 , A61K31/4545 , A61K31/5377 , A61K31/553 , A61K31/551 , C07D405/14 , C07D409/14 , A61K45/06
CPC分类号： C07D487/10 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K31/553 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention encompasses compounds of general formula (1) where in the groups R0 to R3 and L are defined as in claim 1, which are suitable for the 5 treatment of diseases characterized by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.
摘要翻译： 本发明包括通式（1）的化合物，其中R 0至R 3和L的基团如权利要求1中所定义，其适合于治疗以细胞增殖过度或异常为特征的疾病的治疗，其含有化合物 这种和它们作为药物的用途。
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公开(公告)号：US08778929B2
公开(公告)日：2014-07-15
申请号：US13121241
申请日：2009-09-28
IPC分类号： A61P35/00 , A61K31/4439 , C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： The present invention relates to new compounds of general formula (I), wherein the groups R1 to R3, X1, X2, X3 and L1 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof in such a treatment.
摘要翻译： 本发明涉及通式（I）的新化合物，其中R 1至R 3，X 1，X 2，X 3和L 1基团如权利要求1中所定义，其适于治疗以细胞增殖过度或异常为特征的疾病 ，以及其在这种治疗中的用途。
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公开(公告)号：US20110312939A1
公开(公告)日：2011-12-22
申请号：US13121241
申请日：2009-09-28
IPC分类号： A61K31/553 , A61K31/4439 , C07D401/14 , A61K31/444 , A61K31/496 , C07D417/14 , A61K31/506 , C07D487/04 , A61K31/4985 , A61K31/5377 , A61K31/4545 , C07D471/10 , A61K31/551 , A61P35/00 , A61P31/00 , A61P29/00 , A61P37/06 , C07D413/14
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： The present invention relates to new compounds of general formula (I), wherein the groups R1 to R3, X1, X2, X3 and L1 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof in such a treatment.
摘要翻译： 本发明涉及通式（I）的新化合物，其中R 1至R 3，X 1，X 2，X 3和L 1基团如权利要求1中所定义，其适于治疗以细胞增殖过度或异常为特征的疾病 ，以及其在这种治疗中的用途。
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