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公开(公告)号：US08937095B2
公开(公告)日：2015-01-20
申请号：US13937437
申请日：2013-07-09
申请人： Stephan Karl Zahn , Patrizia Sini , Bojan Bister
发明人： Stephan Karl Zahn , Patrizia Sini , Bojan Bister
IPC分类号： C07D209/14 , C07D209/34
CPC分类号： C07D209/34 , C07D209/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： The invention describes dual Aurora kinase/MEK inhibitors and their use in therapy.
摘要翻译： 本发明描述了双极Aurora激酶/ MEK抑制剂及其在治疗中的用途。
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公开(公告)号：US08207179B2
公开(公告)日：2012-06-26
申请号：US12664162
申请日：2008-06-09
申请人： Harald Engelhardt , Bodo Betzemeier , Guido Boehmelt , Ulrich Guertler , Thomas Karner , Oliver Kraemer , Daniel Kuhn , Jens Juergen Quant , Ulrich Reiser , Otmar Schaaf , Flavio Solca , Heinz Stadtmueller , Ulrike Tontsch-Grunt , Matthias Treu , Stephan Karl Zahn
发明人： Harald Engelhardt , Bodo Betzemeier , Guido Boehmelt , Ulrich Guertler , Thomas Karner , Oliver Kraemer , Daniel Kuhn , Jens Juergen Quant , Ulrich Reiser , Otmar Schaaf , Flavio Solca , Heinz Stadtmueller , Ulrike Tontsch-Grunt , Matthias Treu , Stephan Karl Zahn
IPC分类号： A61K31/517
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention encompasses compounds of general Formula (1) wherein R2, R3, Q, W, X, Y and Z are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 2，R 3，Q，W，X，Y和Z如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 其用途是制备具有上述性质的药物。
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公开(公告)号：US20090163465A1
公开(公告)日：2009-06-25
申请号：US12366075
申请日：2009-02-05
申请人： Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
发明人： Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
IPC分类号： A61K31/506 , A61K31/55 , A61K31/553 , A61K31/551 , A61P35/00
CPC分类号： C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要： The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
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公开(公告)号：US20140018372A1
公开(公告)日：2014-01-16
申请号：US13937432
申请日：2013-07-09
申请人： Gerd-Michael MAIER , Anke BAUM , Bodo BETZEMEIER , Manuel HENRY , Rolf HERTER , Ulrich REISER , Patrizia SINI , Dirk WEBER , Ulrike WERTHMANN , Stephan Karl ZAHN
发明人： Gerd-Michael MAIER , Anke BAUM , Bodo BETZEMEIER , Manuel HENRY , Rolf HERTER , Ulrich REISER , Patrizia SINI , Dirk WEBER , Ulrike WERTHMANN , Stephan Karl ZAHN
IPC分类号： C07D209/34 , A61K31/437 , A61K31/506 , A61K31/4045
CPC分类号： C07D209/34 , A61K31/4045 , A61K31/437 , A61K31/506 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： A crystalline form of 3-{3-[1-(4-Dimethylaminomethyl-phenylamino)-1-phenyl-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indol-6-yl}-propynoic acid ethylamide.
摘要翻译： 3- {3- [1-（4-二甲基氨基甲基 - 苯基氨基）-1-苯基 - 甲基 - （Z） - 亚基] -2-氧代-2,3-二氢-1H-吲哚-6-基的结晶形式 } - 丙炔酸乙酰胺。
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公开(公告)号：US20130281429A1
公开(公告)日：2013-10-24
申请号：US13850711
申请日：2013-03-26
申请人： Stephan Karl ZAHN , Guido BOEHMELT , Andreas MANTOULIDIS , Ulrich REISER , Matthias TREU , Ulrich GUERTLER , Andreas SCHOOP , Flavio SOLCA , Ulrike TONTSCH-GRUNT , Ralph BRUECKNER , Charlotte REITHER , Lars HERFURTH , Oliver KRAEMER , Heinz STADTMUELLER , Harald ENGELHARDT
发明人： Stephan Karl ZAHN , Guido BOEHMELT , Andreas MANTOULIDIS , Ulrich REISER , Matthias TREU , Ulrich GUERTLER , Andreas SCHOOP , Flavio SOLCA , Ulrike TONTSCH-GRUNT , Ralph BRUECKNER , Charlotte REITHER , Lars HERFURTH , Oliver KRAEMER , Heinz STADTMUELLER , Harald ENGELHARDT
IPC分类号： C07D239/48 , C07D401/14 , C07D401/12 , C07D487/08 , A61K31/5377 , A61K45/06 , A61K31/506 , A61K31/505 , A61K31/551 , C07D403/12 , C07D409/14
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14 , C07D487/08
摘要： The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，以及其用于制备具有上述药物组合物的用途 提到的属性。
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公开(公告)号：US20090163467A1
公开(公告)日：2009-06-25
申请号：US11747337
申请日：2007-05-11
申请人： Stephan Karl Zahn , Bojan Bister , Guido Boehmelt , Ulrich Guertler , Andreas Mantoulidis , Ulrich Reiser , Andreas Schoop , Flavio Solca , Ulrike Tontsch-Grunt , Matthias Treu
发明人： Stephan Karl Zahn , Bojan Bister , Guido Boehmelt , Ulrich Guertler , Andreas Mantoulidis , Ulrich Reiser , Andreas Schoop , Flavio Solca , Ulrike Tontsch-Grunt , Matthias Treu
IPC分类号： A61K31/397 , C07D401/12 , A61K31/506 , C07D403/12 , C07D401/14 , C07D413/14 , A61K31/5377 , A61K31/496 , C07D417/14 , A61K31/541 , A61P35/00 , A61P29/00 , A61P31/00 , A61P37/00
CPC分类号： C07D405/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention encompasses compounds of general formula (1) wherein R1, R2, R4, X, m, n and p are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1，R 2，R 4，X，m，n和p如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 用于制备具有上述性质的药物组合物。
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公开(公告)号：US20090149438A1
公开(公告)日：2009-06-11
申请号：US12366078
申请日：2009-02-05
申请人： Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
发明人： Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
IPC分类号： A61K31/5377 , C07D413/14 , C07D403/12 , A61K31/506 , A61K31/551 , C07D409/14 , A61K31/553
CPC分类号： C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要： The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
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![Pyrido [5, 4-D] pyrimidines as cell proliferation inhibitors](/abs-image/US/2014/02/18/US08653087B2/abs.jpg.150x150.jpg)
公开(公告)号：US08653087B2
公开(公告)日：2014-02-18
申请号：US13062058
申请日：2009-09-08
申请人： Andreas Mantoulidis , Georg Dahmann , Peter Ettmayer , Christian Klein , Steffen Steurer , Irene Waizenegger , Stephan Karl Zahn
发明人： Andreas Mantoulidis , Georg Dahmann , Peter Ettmayer , Christian Klein , Steffen Steurer , Irene Waizenegger , Stephan Karl Zahn
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, X1, X2, X3, L1 and L2 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or anomalous cell proliferation, and the use thereof in such a treatment.
摘要翻译： 本发明包括通式（1）的化合物，其中R 1至R 4，X 1，X 2，X 3，L 1和L 2基团如权利要求1中所定义，其适用于治疗以过度或异常细胞增殖为特征的疾病， 及其在这种治疗中的用途。
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公开(公告)号：US08623887B2
公开(公告)日：2014-01-07
申请号：US11747337
申请日：2007-05-11
申请人： Stephan Karl Zahn , Bojan Bister , Guido Boehmelt , Ulrich Guertler , Andreas Mantoulidis , Ulrich Reiser , Andreas Schoop , Flavio Solca , Ulrike Tontsch-Grunt , Matthias Treu
发明人： Stephan Karl Zahn , Bojan Bister , Guido Boehmelt , Ulrich Guertler , Andreas Mantoulidis , Ulrich Reiser , Andreas Schoop , Flavio Solca , Ulrike Tontsch-Grunt , Matthias Treu
IPC分类号： A61K31/505 , C07D239/02 , C07D211/56 , C07D211/98
CPC分类号： C07D405/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention encompasses compounds of general formula (1) wherein R1, R2, R4, Rg, X, m, n and p are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中R1，R2，R4，Rg，X，m，n和p如权利要求1中所定义，其适用于治疗特征为过度或异常细胞增殖的疾病， 以及它们用于制备具有上述性质的药物组合物的用途。
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公开(公告)号：US08546443B2
公开(公告)日：2013-10-01
申请号：US13329615
申请日：2011-12-19
IPC分类号： A01N43/38 , A01N43/54 , A61K31/40 , A61K31/505 , C07D209/34 , C07D239/02
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D487/08 , C07D491/10
摘要： The present invention encompasses compounds of general formula (I) wherein the groups R5 to R10, A, L1, B, m and p are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.
摘要翻译： 本发明包括通式（I）的化合物，其中基团R 5至R 10，A，L 1，B，m和p如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病， 含有这些化合物的药物制剂及其作为药物的用途。
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