公开(公告)号：US20060263761A1

公开(公告)日：2006-11-23

申请号：US11373581

申请日：2006-03-10

申请人： Andrew Fontenot ,  Brian Kotzin ,  Lee Newman ,  Lisa Maier

发明人： Andrew Fontenot ,  Brian Kotzin ,  Lee Newman ,  Lisa Maier

IPC分类号： C12Q1/00 ,  G01N33/567 ,  G01N33/20

CPC分类号： G01N33/6863 ,  G01N33/56972 ,  G01N2800/12 ,  G01N2800/24

摘要： The present invention provides for methods for detection, diagnosis and prognosis of beryllium-induced disease. In one embodiment, the methods include exposing immune cells from subjects suspected of having beryllium-induced disease to beryllium and assessing the Th-1 cytokines produced. Other embodiments include the use of exposing immune cells from subjects suspected of having beryllium-induced disease to beryllium and assessing Th-1 cytokines produced and using these assessments to indicate the stage of progression of the disease. Therapeutic methods involve assessing the onset or progression of beryllium-induced disease before during and after exposure to a treatment for the disease.

摘要翻译： 本发明提供了铍诱发疾病的检测，诊断和预后的方法。 在一个实施方案中，所述方法包括将怀疑患有铍诱发疾病的受试者的免疫细胞暴露于铍并评估产生的Th-1细胞因子。 其他实施方案包括将怀疑患有铍诱发疾病的受试者的免疫细胞暴露于铍并评估所产生的Th1细胞因子并使用这些评估来指示疾病进展阶段的用途。 治疗方法包括在暴露于该疾病的治疗之前和之后评估铍诱发的疾病的发作或进展。