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公开(公告)号：US20110182952A1
公开(公告)日：2011-07-28
申请号：US13084228
申请日：2011-04-11
IPC分类号： A61K9/14 , A61P23/02 , A61K31/167 , A61K31/245
CPC分类号： A61L24/0015 , A61L24/0031 , A61L2300/402 , A61L2430/36
摘要： A pharmaceutical composition for embolization of blood vessels, especially for benign tumours, comprises a polymeric embolic agent and, associated with the polymer in a releasable form, a local anaesthetic agent. The polymer is preferably in particulate form, such as in the form of microspheres. A suitable polymer Is a crosslinked polyvinyl alcohol polymer formed by the copolymerization of PVA macromer with other ethylenically unsaturated monomers. The composition provides a synergistic treatment for the symptoms of tumours such as uterine fibrioids, leading to size regression as well as pain relief.
摘要翻译： 用于栓塞血管，特别是良性肿瘤的药物组合物包含聚合物栓塞剂，并且以可释放形式的聚合物与局部麻醉剂相关联。 聚合物优选为颗粒形式，例如以微球的形式。 合适的聚合物是通过PVA大分子单体与其它烯属不饱和单体的共聚形成的交联聚乙烯醇聚合物。 该组合物对诸如子宫纤维样肿瘤的症状提供协同治疗，导致大小消退以及疼痛缓解。
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公开(公告)号：US20120016082A1
公开(公告)日：2012-01-19
申请号：US13243923
申请日：2011-09-23
IPC分类号： C08F8/32 , C08F2/38 , C07D207/46
CPC分类号： C08F246/00 , C07D207/46 , C07F9/091 , C07F9/5537 , C08F4/00
摘要： An initiator for the terminal group of the polymer product of an atom or group radical transfer polymerisation has an activated carboxyl or an amine group which is reacted with an amine or carboxyl (respectively) group containing biologically active compound. The initiator is preferably 4-(3-(2-bromo, 2-methyl-propionate)phenyl)-propionic acid N-hydroxysuccinimide ester or 2-bromo, 2-methyl-propionic acid N-hydroxysuccinimide ester. The monomers preferably comprise a zwitterionic monomer such as 2-methacryloxyethyl-2′-trimethyl ammoniumethyl phosphate inner salt.
摘要翻译： 原子或基团自由基转移聚合的聚合物产物的末端基团的引发剂具有活化的羧基或与含有胺或羧基（分别）含有生物活性化合物的基团）反应的胺基。 引发剂优选为4-（3-（2-溴，2-甲基 - 丙酸酯）苯基） - 丙酸N-羟基琥珀酰亚胺酯或2-溴-2-甲基 - 丙酸N-羟基琥珀酰亚胺酯。 单体优选包含两性离子单体，例如2-甲基丙烯酰氧基乙基-2'-三甲基磷酸铵乙酯内盐。
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