公开(公告)号：US20050159556A1

公开(公告)日：2005-07-21

申请号：US11025968

申请日：2005-01-03

申请人： Andrew Lewis ,  Sean Willis ,  Steven Armes ,  Emma Lobb ,  Yinghua Ma

发明人： Andrew Lewis ,  Sean Willis ,  Steven Armes ,  Emma Lobb ,  Yinghua Ma

IPC分类号： A61K9/10 ,  A61K47/32 ,  C08F4/40 ,  C08F20/22 ,  C08F246/00 ,  C08F293/00

CPC分类号： C08F4/40 ,  C08F246/00 ,  C08F293/005 ,  C08F2438/01

摘要： Polymers may be made from zwitterionic monomers having controlled architectures and molecular weights, using living polymerisations such as group or atom transfer radical polymerisation. For instance polymers may be formed by atom transfer radical polymerisation using a copper chloride catalyst, a ligand which is water soluble, and a water soluble tertiary alkyl halide initiator to form homopolymers having controlled polydispersities of less than 1.5 and block copolymers with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2′-trimethylammoniumethyl phosphate inner salt. The block copolymers may spontaneously form micelles, believed to have zwitterionic, for instance phosphorylcholine, groups at the external surface, which may be useful as drug delivery systems with improved biocompatibility.