公开(公告)号：US20050159556A1

公开(公告)日：2005-07-21

申请号：US11025968

申请日：2005-01-03

申请人： Andrew Lewis ,  Sean Willis ,  Steven Armes ,  Emma Lobb ,  Yinghua Ma

发明人： Andrew Lewis ,  Sean Willis ,  Steven Armes ,  Emma Lobb ,  Yinghua Ma

IPC分类号： A61K9/10 ,  A61K47/32 ,  C08F4/40 ,  C08F20/22 ,  C08F246/00 ,  C08F293/00

CPC分类号： C08F4/40 ,  C08F246/00 ,  C08F293/005 ,  C08F2438/01

摘要： Polymers may be made from zwitterionic monomers having controlled architectures and molecular weights, using living polymerisations such as group or atom transfer radical polymerisation. For instance polymers may be formed by atom transfer radical polymerisation using a copper chloride catalyst, a ligand which is water soluble, and a water soluble tertiary alkyl halide initiator to form homopolymers having controlled polydispersities of less than 1.5 and block copolymers with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2′-trimethylammoniumethyl phosphate inner salt. The block copolymers may spontaneously form micelles, believed to have zwitterionic, for instance phosphorylcholine, groups at the external surface, which may be useful as drug delivery systems with improved biocompatibility.

公开(公告)号：US20090317443A1

公开(公告)日：2009-12-24

申请号：US12373334

申请日：2007-07-16

申请人： Sean Willis ,  Vincent James O'Byrne ,  Samantha Ryan

发明人： Sean Willis ,  Vincent James O'Byrne ,  Samantha Ryan

IPC分类号： A61K9/00 ,  B05D3/00 ,  B05D1/36 ,  A61P43/00 ,  A61F2/82

CPC分类号： A61L31/10 ,  A61L31/14

摘要： A method forming a coated implant is described. The implant comprises a surface which is first coated with a primer and subsequently with a biocompatible polymer capable of forming a covalent bond to the primer. The polymer coating is then crosslinked. The invention also relates to implants, in particular, stents, coated with such a coating.

摘要翻译： 描述了形成涂覆植入物的方法。 植入物包括首先用引物涂覆的表面，随后与能够与引物形成共价键的生物相容性聚合物。 然后将聚合物涂层交联。 本发明还涉及用这种涂层涂覆的植入物，特别是支架。

公开(公告)号：US20090274762A1

公开(公告)日：2009-11-05

申请号：US12305048

申请日：2007-06-22

申请人： Sean Willis ,  Rosemary Palmer

发明人： Sean Willis ,  Rosemary Palmer

IPC分类号： A61K47/30 ,  A61K9/14 ,  A61K31/704 ,  A61K31/4545

CPC分类号： A61K9/19 ,  A61J1/065 ,  A61J1/1406 ,  A61J1/1412 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/1641 ,  A61K9/1676 ,  A61K9/1682 ,  A61K31/4745 ,  A61K31/704 ,  A61K45/06 ,  B65B31/027 ,  B65B63/08 ,  B65D81/2015 ,  B82Y5/00

摘要： A pharmaceutical product comprising lyophilised polymer matrix including a biologically active compound, of particular utility for embolisation, having improved rehydration properties is packaged in an airtight package under vacuum.

摘要翻译： 包含冻干聚合物基质的药物产品包括具有改善的再水化性质的特别用于栓塞的生物活性化合物，其在真空下封装在气密包装中。

公开(公告)号：US09107833B2

公开(公告)日：2015-08-18

申请号：US12305048

申请日：2007-06-22

申请人： Sean Willis ,  Rosemary Palmer

发明人： Sean Willis ,  Rosemary Palmer

IPC分类号： A61K9/00 ,  A61K9/16 ,  B82Y5/00 ,  A61K9/19

CPC分类号： A61K9/19 ,  A61J1/065 ,  A61J1/1406 ,  A61J1/1412 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/1641 ,  A61K9/1676 ,  A61K9/1682 ,  A61K31/4745 ,  A61K31/704 ,  A61K45/06 ,  B65B31/027 ,  B65B63/08 ,  B65D81/2015 ,  B82Y5/00

摘要： A pharmaceutical product comprising lyophilized polymer matrix including a biologically active compound, of particular utility for embolization, having improved rehydration properties is packaged in an airtight package under vacuum.

摘要翻译： 包含冻干聚合物基质的药物产品包括具有改善的再水合性质的特别用于栓塞的生物活性化合物，其在真空下封装在气密包装中。

公开(公告)号：US08252878B2

公开(公告)日：2012-08-28

申请号：US12373412

申请日：2007-07-16

申请人： Andrew Lennard Lewis ,  Sean Willis ,  Stephen Alister Jones ,  Vincent James O'Byrne ,  David Michael Grey ,  Michael John Driver ,  Samantha Ryan ,  Richard Paul Redman

发明人： Andrew Lennard Lewis ,  Sean Willis ,  Stephen Alister Jones ,  Vincent James O'Byrne ,  David Michael Grey ,  Michael John Driver ,  Samantha Ryan ,  Richard Paul Redman

IPC分类号： C08F230/02 ,  A61F2/00 ,  A61L33/00 ,  A61K6/083

CPC分类号： C08F220/18 ,  C08F212/08 ,  C08F220/14

摘要： A novel class of polymers obtainable by copolymerising a monomer mixture comprising (i) hydrophilic monomer of general formula (I) Y—B—X; (ii) styrene or a substituted styrene, a monomer or mixture of monomers which when polymerized form a polymer with a Tg lower than the Tg of a homopolymer of monomer (I) and lower than the Tg of a homopolymer of monomer (ii); and a monomer having a crosslinkable group is described. The invention also relates to a method for producing such polymers, implants coated with the polymers and methods for forming the same.

摘要翻译： 通过共聚单体混合物获得的一类新型聚合物，其包含（i）通式（I）Y-B-X的亲水性单体; （ii）苯乙烯或取代的苯乙烯，当聚合形成Tg低于单体（I）的均聚物的Tg并低于单体（ii）的均聚物的Tg）的聚合物时的单体或单体混合物; 并描述具有可交联基团的单体。 本发明还涉及一种生产这种聚合物的方法，用该聚合物涂覆的种植体及其形成方法。

公开(公告)号：US20090304770A1

公开(公告)日：2009-12-10

申请号：US12373412

申请日：2007-07-16

申请人： Andrew Lennard Lewis ,  Sean Willis ,  Stephen Alister Jones ,  Vincent James O'Byrne ,  David Micheal Grey ,  Michael John Driver ,  Samantha Ryan ,  Richard Paul Redman

发明人： Andrew Lennard Lewis ,  Sean Willis ,  Stephen Alister Jones ,  Vincent James O'Byrne ,  David Micheal Grey ,  Michael John Driver ,  Samantha Ryan ,  Richard Paul Redman

IPC分类号： A61F2/06 ,  A61K8/81 ,  A61L33/06 ,  C08F30/02 ,  A61K31/44 ,  A61K31/57 ,  A61F2/82 ,  A61F2/02

CPC分类号： C08F220/18 ,  C08F212/08 ,  C08F220/14

摘要： A novel class of polymers obtainable by copolymerising a monomer mixture comprising (i) hydrophilic monomer of general formula (I) Y—B—X; (ii) styrene or a substituted styrene, a monomer or mixture of monomers which when polymerised form a polymer with a Tg lower than the Tg of a homopolymer of monomer (I) and lower than the Tg of a homopolymer of monomer (ii); and a monomer having a crosslinkable group is described. The invention also relates to a method for producing such polymers, implants coated with the polymers and methods for forming the same.

摘要翻译： 通过共聚单体混合物获得的一类新型聚合物，其包含（i）通式（I）Y-B-X的亲水性单体; （ii）苯乙烯或取代的苯乙烯，当聚合形成Tg低于单体（I）的均聚物的Tg并低于单体（ii）的均聚物的Tg）的聚合物时的单体或单体的混合物; 并描述具有可交联基团的单体。 本发明还涉及一种生产这种聚合物的方法，用该聚合物涂覆的种植体及其形成方法。