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公开(公告)号：US06715486B2
公开(公告)日：2004-04-06
申请号：US09773261
申请日：2001-01-31
IPC分类号： A61M1600
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/43 , A61M2206/16 , A61M2206/18
摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from the larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater air flow and powder dispersion, without any increased effort by the patient.
摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的空气流动和粉末分散，而不会增加患者的任何增加的努力。
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公开(公告)号：US06971384B2
公开(公告)日：2005-12-06
申请号：US10782449
申请日：2004-02-19
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/43 , A61M2206/16 , A61M2206/18
摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater airflow and powder dispersion, without any increased effort by the patient.
摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的气流和粉末分散，而不会增加患者的任何增加的努力。
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公开(公告)号：US20060005833A1
公开(公告)日：2006-01-12
申请号：US11224406
申请日：2005-09-12
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/43 , A61M2206/16 , A61M2206/18
摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater airflow and powder dispersion, without any increased effort by the patient.
摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的气流和粉末分散，而不会增加患者的任何增加的努力。
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公开(公告)号：US20050165365A1
公开(公告)日：2005-07-28
申请号：US11058381
申请日：2005-02-15
申请人： Brian Newton , Andrew Cote , Charles Ganem
发明人： Brian Newton , Andrew Cote , Charles Ganem
CPC分类号： A61M39/26 , A61M39/045 , A61M2039/262 , A61M2039/266 , Y10T137/0318 , Y10T137/87957
摘要： A medical valve has an interior flow path having a volume that is substantially the same when in either the closed mode (when the valve is closed) or the open mode (when the valve is open). To those ends, the medical valve has a housing forming an interior, and a valve mechanism (within the interior) having a substantially rigid translating member with a bore. The interior of the housing has a flow path that includes at least a portion of the bore of the translating member. As noted above, the open mode volume is substantially equal to the closed mode volume.
摘要翻译： 当处于关闭模式（当关闭阀门）或打开模式时（当阀门打开时），医疗阀门具有一个体积基本相同的内部流路。 为此，医疗阀具有形成内部的壳体，以及具有基本上刚性的具有孔的平移构件的阀机构（内部）。 壳体的内部具有包括平移构件的孔的至少一部分的流动路径。 如上所述，打开模式体积基本上等于封闭模式体积。
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公开(公告)号：US20060293629A1
公开(公告)日：2006-12-28
申请号：US11435313
申请日：2006-05-16
申请人： Andrew Cote , Brian Newton , Charles Ganem
发明人： Andrew Cote , Brian Newton , Charles Ganem
IPC分类号： A61M5/00
CPC分类号： A61M39/26 , A61M39/045 , A61M2039/262 , A61M2039/263 , A61M2039/266
摘要： A medical valve includes a housing having an interior forming an inlet and an outlet. A longitudinally movable member is secured within the interior of the housing. External to the movable member and within the interior is a fluid path. Movement of the movable member controls fluid flow between the inlet and the outlet via the fluid path. The outlet produces no greater than a negligible drawback or positive push during withdrawal of a nozzle.
摘要翻译： 医疗阀包括具有形成入口和出口的内部的壳体。 纵向移动件固定在外壳的内部。 在可移动构件外部和内部的外部是流体路径。 可移动构件的移动通过流体路径控制入口和出口之间的流体流动。 出口在抽出喷嘴期间不会产生不大可忽略的缺点或正向推动。
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公开(公告)号：US20050038397A1
公开(公告)日：2005-02-17
申请号：US10895638
申请日：2004-07-21
申请人： Brian Newton , Andrew Cote , Charles Ganem , David Woyak , Richard Boisjoly
发明人： Brian Newton , Andrew Cote , Charles Ganem , David Woyak , Richard Boisjoly
CPC分类号： A61M39/26 , A61M39/045 , A61M2039/262 , A61M2039/263 , A61M2039/267
摘要： A gland member within a medical valve is configured to have a substantially consistent or enlarging internal volume as the valve transitions from a closed mode to an open mode. To that end, the valve has a housing forming an interior containing a flow path, and a stationary post member within the interior. The post member has a lumen that is a part of the flow path. The lumen has an opening to the interior of the housing. The valve further includes a gland member circumscribing the post member to produce a variable volume region formed at least in part between the gland member itself and the post member. In addition, the variable volume region is a part of the flow path, while the gland member occludes the post lumen opening when in the closed mode. The variable volume region has an open volume (i.e., when the valve is in the open mode) that is no less than its closed volume (i.e., when the valve is in the closed mode).
摘要翻译： 当阀门从关闭模式转换到打开模式时，医疗阀门中的压盖构件配置成具有基本一致或扩大的内部容积。 为此，该阀具有形成内部流体的内部的壳体，以及在该内部内部的固定的支柱构件。 柱构件具有作为流动路径的一部分的内腔。 管腔具有到壳体内部的开口。 所述阀还包括限定所述柱构件的压盖构件，以产生至少部分地形成在所述压盖构件本身和所述柱构件之间的可变容积区域。 此外，可变容积区域是流动路径的一部分，而当处于关闭模式时，压盖构件封闭管腔开口。 可变体积区域具有开口体积（即，当阀处于打开模式时），其不小于其闭合容积（即，当阀处于关闭模式时）。
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