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公开(公告)号：US20060005833A1
公开(公告)日：2006-01-12
申请号：US11224406
申请日：2005-09-12
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/43 , A61M2206/16 , A61M2206/18
摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater airflow and powder dispersion, without any increased effort by the patient.
摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的气流和粉末分散，而不会增加患者的任何增加的努力。
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公开(公告)号：US06715486B2
公开(公告)日：2004-04-06
申请号：US09773261
申请日：2001-01-31
IPC分类号： A61M1600
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/43 , A61M2206/16 , A61M2206/18
摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from the larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater air flow and powder dispersion, without any increased effort by the patient.
摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的空气流动和粉末分散，而不会增加患者的任何增加的努力。
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公开(公告)号：US06971384B2
公开(公告)日：2005-12-06
申请号：US10782449
申请日：2004-02-19
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/43 , A61M2206/16 , A61M2206/18
摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater airflow and powder dispersion, without any increased effort by the patient.
摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的气流和粉末分散，而不会增加患者的任何增加的努力。
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公开(公告)号：US07958890B2
公开(公告)日：2011-06-14
申请号：US12328657
申请日：2008-12-04
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/43 , A61M2206/16 , A61M2206/18
摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater airflow and powder dispersion, without any increased effort by the patient.
摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的气流和粉末分散，而不会增加患者的任何增加的努力。
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公开(公告)号：US06427688B1
公开(公告)日：2002-08-06
申请号：US09495494
申请日：2000-02-01
申请人： Michael Ligotke , Andrew W. Gieschen , Robert F. Eisele , Thomas R. Jackson , Jeffrey Chen , Bernard Greenspan , Clyde Witham , Gary Ward
发明人： Michael Ligotke , Andrew W. Gieschen , Robert F. Eisele , Thomas R. Jackson , Jeffrey Chen , Bernard Greenspan , Clyde Witham , Gary Ward
IPC分类号： A61M1500
CPC分类号： A61M15/0086 , A61M15/0008 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0048 , A61M15/02 , A61M2202/064 , A61M2205/43 , A61M2206/16 , A61M2206/18
摘要： A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from the larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater air flow and powder dispersion, without any increased effort by the patient.
摘要翻译： 干粉吸入器具有包含珠的分散室。 干粉的剂量被释放到室中，或者进入切向连接到室中的入口。 当患者在鼻梁或喉舌上吸气时，空气循环移动通过分散室以驱动珠子。 珠子与腔室表面或珠子上的药物颗粒反复滚动，反弹并碰撞。 较小的活性药物颗粒与较大的载体颗粒和彼此分离，并且由患者产生并吸入粉末气溶胶。 珠子优选是轻质的，使得它们可以被快速加速和移动，即使具有标称的灵感。 吸入器的流动阻力也通过珠子减小，允许更大的空气流动和粉末分散，而不会增加患者的任何增加的努力。
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公开(公告)号：US06273085B1
公开(公告)日：2001-08-14
申请号：US09226054
申请日：1999-01-05
申请人： Robert Eisele , Karen Davies , Jeffrey Chen , Bernard Greenspan
发明人： Robert Eisele , Karen Davies , Jeffrey Chen , Bernard Greenspan
IPC分类号： A61M1500
CPC分类号： A61M15/0045 , A61M15/0006 , A61M15/0043 , A61M15/0048 , A61M2016/0024
摘要： A dry powder inhaler has a lid pivotally attached to an inhaler housing. A medicine containing cartridge is attached to the top of the housing and includes a cartridge ring with apertures for holding dry powdered medicine. A slide-groove assembly located on the underside of the lid advances the cartridge ring to a next aperture when a user first opens, then closes the lid. A venturi air passageway assembly is contained within the housing of the dry powdered inhaler. The venturi air passageway assembly includes a tapered inlet section, a throat section, and a tapered outlet section. A pressure switch is advantageously located within the housing for actuating the mixing process within the mixing chamber. During inhalation, the pressure switch contained within the housing actuates the motor driven impeller within the mixing chamber of the inhaler when the pressure within the venturi air passageway reaches a predetermined level. The pressure at which the pressure switch closes corresponds to a specifically calibrated inhalation flow rate.
摘要翻译： 干粉吸入器具有枢转地附接到吸入器壳体的盖。 药物容纳盒附接到壳体的顶部，并且包括具有用于保持干粉药物的孔的药筒环。 当用户首次打开时，位于盖子下侧的滑槽组件将盒环推进到下一个孔，然后关闭盖子。 文丘里空气通道组件包含在干粉吸入器的壳体内。 文丘里空气通道组件包括锥形入口部分，喉部部分和锥形出口部分。 压力开关有利地位于壳体内，用于致动混合室内的混合过程。 在吸入期间，当文丘里空气通道内的压力达到预定水平时，容纳在壳体内的压力开关致动吸入器的混合室内的马达驱动的叶轮。 压力开关关闭的压力对应于特定校准的吸入流量。
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公开(公告)号：US6006747A
公开(公告)日：1999-12-28
申请号：US821753
申请日：1997-03-20
申请人： Robert Eisele , Karen Davies , Jeffrey Chen , Bernard Greenspan
发明人： Robert Eisele , Karen Davies , Jeffrey Chen , Bernard Greenspan
CPC分类号： A61M15/0045 , A61M15/0006 , A61M15/0043 , A61M15/0048 , A61M2016/0024
摘要： A dry powder inhaler has a lid pivotally attached to an inhaler housing. A medicine containing cartridge is attached to the top of the housing and includes a cartridge ring with apertures for holding dry powdered medicine. A slide-groove assembly located on the underside of the lid advances the cartridge ring to a next aperture when a user first opens, then closes the lid. A venturi air passageway assembly is contained within the housing of the dry powdered inhaler. The venturi air passageway assembly includes a tapered inlet section, a throat section, and a tapered outlet section. A pressure switch is advantageously located within the housing for actuating the mixing process within the mixing chamber. During inhalation, the pressure switch contained within the housing actuates the motor driven impeller within the mixing chamber of the inhaler when the pressure within the venturi air passageway reaches a predetermined level. The pressure at which the pressure switch closes corresponds to a specifically calibrated inhalation flow rate.
摘要翻译： 干粉吸入器具有枢转地附接到吸入器壳体的盖。 药物容纳盒附接到壳体的顶部，并且包括具有用于保持干粉药物的孔的药筒环。 当用户首次打开时，位于盖子下侧的滑槽组件将盒环推进到下一个孔，然后关闭盖子。 文丘里空气通道组件包含在干粉吸入器的壳体内。 文丘里空气通道组件包括锥形入口部分，喉部部分和锥形出口部分。 压力开关有利地位于壳体内，用于致动混合室内的混合过程。 在吸入期间，当文丘里空气通道内的压力达到预定水平时，容纳在壳体内的压力开关致动吸入器的混合室内的马达驱动的叶轮。 压力开关关闭的压力对应于特定校准的吸入流量。
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公开(公告)号：US06651655B1
公开(公告)日：2003-11-25
申请号：US09562798
申请日：2000-05-02
申请人： Cynthia Licalsi , Gary Ward , Bernard Greenspan , Clyde Witham
发明人： Cynthia Licalsi , Gary Ward , Bernard Greenspan , Clyde Witham
IPC分类号： A61M1500
CPC分类号： A61M15/0028 , A61M15/0043 , A61M2202/066 , A61M2202/30
摘要： In a method for creating an immune response, a vaccine is prepared in the form of a dry powder. The powder particles have an aerodynamic particle size range from 1-100 microns. A dose of powder is loaded into a dry powder inhaler. The dose is inhaled with an inspiratory flow rate of less than 60 liters per minute. A mucosal immune response is created via particles of the vaccine material depositing on the upper respiratory tract. A systemic immune response is created via particles of the vaccine material depositing into the deep lung. The vaccine material is size reduced by e.g., jet milling, into the desired range, yet vaccine potency is retained.
摘要翻译： 在产生免疫应答的方法中，以干燥粉末的形式制备疫苗。 粉末颗粒的空气动力学粒度范围为1-100微米。 将一剂粉末装入干粉吸入器。 吸入剂量的吸气流速小于60升/分钟。 通过沉积在上呼吸道上的疫苗材料的颗粒产生粘膜免疫应答。 通过沉积到深肺中的疫苗材料的颗粒产生全身免疫应答。 通过例如喷射研磨将疫苗材料的尺寸减小到所需的范围，但保留了疫苗效力。
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