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    Left ventricular access lead for heart failure pacing
    1.
    发明授权
    Left ventricular access lead for heart failure pacing 失效
    心律失常起搏的左心室通路

    公开(公告)号：US5935160A

    公开(公告)日：1999-08-10

    申请号：US787274

    申请日：1997-01-24

    申请人： Angelo Auricchio ,  Rodney W. Salo ,  Bruce A. Tockman ,  Ronald W. Heil, Jr. ,  Randy Westlund ,  Stuart R. Chastain

    发明人： Angelo Auricchio ,  Rodney W. Salo ,  Bruce A. Tockman ,  Ronald W. Heil, Jr. ,  Randy Westlund ,  Stuart R. Chastain

    IPC分类号： A61N1/368 ,  A61N1/05

    CPC分类号： A61N1/056 ,  A61N2001/0585

    摘要： An elongated monopolar or bipolar coronary vein lead having a reduced outer diameter and especially adapted to be advanced into a selected coronary vein for delivering a pacing signal to a predetermined region of a patient's heart, such as the left ventricle. A method of using the lead for pacing a patient's heart in the treatment of heart failure is also described. The method for pacing the heart includes advancing the coronary vein lead through both the coronary sinus and into a selected coronary vein of a patient's heart, connecting the lead to an electrical pacing source and applying electrical stimulation to a particular chamber of the patient's heart via the implanted lead. The lead includes a flexible tip and transition ring that enhances the ability to guide the lead through the coronary veins.

    摘要翻译： 具有减小的外径的细长单极或双极冠状静脉引线，并且特别适于前进到选定的冠状静脉以将起搏信号传送到患者心脏例如左心室的预定区域。 还描述了使用引线将患者心脏起搏治疗心力衰竭的方法。 用于起搏心脏的方法包括将冠状静脉导管穿过冠状窦并进入患者心脏的选定的冠状静脉，将导线连接到起搏源，并通过电刺激源将电刺激施加到患者心脏的特定腔室 植入铅。 引线包括一个灵活的尖端和过渡环，增强引导引导通过冠状静脉的能力。

    Seal for use with medical device and system
    3.
    发明授权
    Seal for use with medical device and system 失效
    用于医疗器械和系统的密封

    公开(公告)号：US07412290B2

    公开(公告)日：2008-08-12

    申请号：US10968305

    申请日：2004-10-20

    申请人： Aaron W. Janke ,  Larry L. Hum ,  Randy Westlund ,  Ronald W. Heil, Jr. ,  Bruce Tockman

    发明人： Aaron W. Janke ,  Larry L. Hum ,  Randy Westlund ,  Ronald W. Heil, Jr. ,  Bruce Tockman

    IPC分类号： A61N1/372

    CPC分类号： A61N1/0573 ,  A61N1/0565

    摘要： A seal adapted for use with medical devices is provided with a lead having a distal tip electrode. The distal tip of the lead is adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead can include a fixation helix for securing the electrode to cardiac tissue. The lead assembly can alternatively include an open lumen lead tip. A seal is provided within the lead tip assembly such that the seal is expanded to prevent or limit further entry of fluids through the lead tip. The seal includes an expandable matrix, such as a hydrogel. The seal is formed on or within the lead when the lead and the seal comes into contact with a fluid and expands. The seal is also formed as a plug which is deployed through the medical device, and expands as the plug absorbs fluid. A housing incorporating the seal can also be attached to a portion of the medical device to provide the seal.

    摘要翻译： 适于与医疗装置一起使用的密封件设置有具有远端尖端电极的引线。 引线的远端适于植入在心脏上或其周围，并用于连接到用于监测或刺激心脏活动的系统。 引线可以包括用于将电极固定到心脏组织的固定螺旋。 导线组件可以替代地包括开放的管腔引线端头。 在引线端头组件内设置密封件，使得密封件被膨胀以防止或限制流体进一步通过引线头进入。 密封件包括可膨胀基质，例如水凝胶。 当铅和密封件与流体接触并膨胀时，密封件形成在引线上或内部。 密封件还形成为通过医疗装置展开的塞子，并且当塞子吸收流体时膨胀。 结合密封件的壳体也可以附接到医疗装置的一部分以提供密封。

    Leads for pacing and/or sensing the heart from within the coronary veins
    4.
    发明授权
    Leads for pacing and/or sensing the heart from within the coronary veins 有权

    公开(公告)号：US06584362B1

    公开(公告)日：2003-06-24

    申请号：US09651340

    申请日：2000-08-30

    申请人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Peter T. Kelley ,  Bruce Tockman ,  Randy Westlund ,  Jay A. Warren

    发明人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Peter T. Kelley ,  Bruce Tockman ,  Randy Westlund ,  Jay A. Warren

    IPC分类号： A61N105

    CPC分类号： A61N1/056 ,  A61N1/057 ,  A61N2001/0585

    摘要： A lead for monitoring or stimulating cardiac activity is provided. The lead is adapted for implantation on or about the heart within the coronary vasculature and for connection to a signal generator. The lead body has one or more electrodes associated therewith. The lead is constructed and arranged so that when it is implanted, the electrodes are housed in the coronary vasculature and urged into intimate contact a vessel wall. A method for implanting the lead into the coronary vasculature is also provided, the method comprising the steps of inserting a stylet into the lead, inserting the lead into the coronary sinus, advancing the lead from the coronary sinus toward the toward the left atrium and into a coronary vein, removing the stylet, and sensing and pacing the heart. Alternatively, the method comprises placing a guide catheter into the coronary sinus, threading a guide wire into the coronary veins, pushing the lead over the guide wire and into the coronary sinus or the coronary vein, and sensing and pacing the heart via the lead in its implanted site in the coronary sinus or the coronary vein.

    Implantable lead with dissolvable coating for improved fixation and extraction
    5.
    发明授权
    Implantable lead with dissolvable coating for improved fixation and extraction 失效

    公开(公告)号：US06584363B2

    公开(公告)日：2003-06-24

    申请号：US09906571

    申请日：2001-07-16

    申请人： Ronald W. Heil, Jr. ,  John E. Heil ,  Randy Westlund

    发明人： Ronald W. Heil, Jr. ,  John E. Heil ,  Randy Westlund

    IPC分类号： A61N105

    CPC分类号： A61N1/0568 ,  A61N1/056

    摘要： A cardiac rhythm management system provides an endocardial cardiac rhythm management lead with an at least partially dissolvable coating at least partially on insulating portions of the lead body at or near its distal end. Upon dissolution, the coating promotes tissue ingrowth to secure the lead in place within fragile vascular structures or elsewhere. Dissolution of one such coating releases a therapeutic agent, such as a steroid that modifies the fibrotic scar tissue content of tissue ingrowth, such that the resulting bond between the tissue and the lead is weak, so that the lead can be easily extracted if desired. One such lead includes an insulating elongate body carrying at least. The lead also includes an at least partially dissolvable coating on an insulating portion of the peripheral distal lead surface. The coating provides one or more of a rough surface, a porous surface, or a swollen surface after being exposed to an aqueous substance.

    Implantable lead with dissolvable coating for improved fixation and extraction
    7.
    发明授权
    Implantable lead with dissolvable coating for improved fixation and extraction 失效
    可植入铅，可溶解涂层，用于改进固定和提取

    公开(公告)号：US07218971B2

    公开(公告)日：2007-05-15

    申请号：US10608850

    申请日：2003-06-24

    申请人： Ronald W. Heil, Jr. ,  John E. Heil ,  Randy Westlund

    发明人： Ronald W. Heil, Jr. ,  John E. Heil ,  Randy Westlund

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0568 ,  A61N1/056

    摘要： A cardiac rhythm management system provides an endocardial cardiac rhythm management lead with an at least partially dissolvable coating at least partially on insulating portions of the lead body at or near its distal end. Upon dissolution, the coating promotes tissue ingrowth to secure the lead in place within fragile vascular structures or elsewhere. Dissolution of one such coating releases a therapeutic agent, such as a steroid that modifies the fibrotic scar tissue content of tissue ingrowth, such that the resulting bond between the tissue and the lead is weak, so that the lead can be easily extracted if desired. One such lead includes an insulating elongate body carrying at least. The lead also includes an at least partially dissolvable coating on an insulating portion of the peripheral distal lead surface. The coating provides one or more of a rough surface, a porous surface, or a swollen surface after being exposed to an aqueous substance.

    摘要翻译： 心脏节律管理系统提供心内心律管理引线，至少部分地可以在其远端处或其远端处的引线体的绝缘部分上具有至少部分可溶解的涂层。 溶解后，涂层促进组织向内生长，以将铅固定在脆弱的血管结构或其他地方。 一种这样的涂层的溶解释放治疗剂，例如修饰组织向内生长的纤维化瘢痕组织含量的类固醇，使得组织和引线之间产生的结合较弱，从而如果需要，铅可以容易地提取。 一个这样的引线包括至少承载的绝缘细长体。 引线还包括在外周远端引线表面的绝缘部分上的至少部分可溶解的涂层。 在暴露于含水物质之后，涂层提供粗糙表面，多孔表面或溶胀表面中的一种或多种。

    Leads for pacing and/or sensing the heart from within the coronary veins
    8.
    发明授权
    Leads for pacing and/or sensing the heart from within the coronary veins 有权

    公开(公告)号：US07139614B2

    公开(公告)日：2006-11-21

    申请号：US10431136

    申请日：2003-05-07

    申请人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Peter T. Kelley ,  Bruce Tockman ,  Randy Westlund ,  Jay A. Warren

    发明人： Avram Scheiner ,  Ronald W. Heil, Jr. ,  Peter T. Kelley ,  Bruce Tockman ,  Randy Westlund ,  Jay A. Warren

    IPC分类号： A61N1/05

    CPC分类号： A61N1/056 ,  A61N1/057 ,  A61N2001/0585

    摘要： A lead for monitoring or stimulating cardiac activity is provided. The lead is adapted for implantation on or about the heart within the coronary vasculature and for connection to a signal generator. The lead body has one or more electrodes associated therewith. The lead is constructed and arranged so that when it is implanted, the electrodes are housed in the coronary vasculature and urged into intimate contact a vessel wall. A method for implanting the lead into the coronary vasculature is also provided, the method comprising the steps of inserting a stylet into the lead, inserting the lead into the coronary sinus, advancing the lead from the coronary sinus toward the toward the left atrium and into a coronary vein, removing the stylet, and sensing and pacing the heart. Alternatively, the method comprises placing a guide catheter into the coronary sinus, threading a guide wire into the coronary veins, pushing the lead over the guide wire and into the coronary sinus or the coronary vein, and sensing and pacing the heart via the lead in its implanted site in the coronary sinus or the coronary vein.

    Implantable lead with dissolvable coating for improved fixation and extraction
    9.
    发明授权
    Implantable lead with dissolvable coating for improved fixation and extraction 有权
    可植入铅，可溶解涂层，用于改进固定和提取

    公开(公告)号：US06304786B1

    公开(公告)日：2001-10-16

    申请号：US09280096

    申请日：1999-03-29

    申请人： Ronald W. Heil, Jr. ,  John E. Heil ,  Randy Westlund

    发明人： Ronald W. Heil, Jr. ,  John E. Heil ,  Randy Westlund

    IPC分类号： A61N105

    CPC分类号： A61N1/0568 ,  A61N1/056

    摘要： A cardiac rhythm management system provides an endocardial cardiac rhythm management lead with an at least partially dissolvable coating at least partially on insulating portions of the lead body at or near its distal end. Upon dissolution, the coating promotes tissue ingrowth to secure the lead in place within fragile vascular structures or elsewhere. Dissolution of one such coating releases a therapeutic agent, such as a steroid that modifies the fibrotic scar tissue content of tissue ingrowth, such that the resulting bond between the tissue and the lead is weak, so that the lead can be easily extracted if desired. One such lead includes an insulating elongate body carrying at least. The lead also includes an at least partially dissolvable coating on an insulating portion of the peripheral distal lead surface. The coating provides one or more of a rough surface, a porous surface, or a swollen surface after being exposed to an aqueous substance.

    摘要翻译： 心脏节律管理系统提供心内心律管理引线，其至少部分地可以在其远端处或其远端处的引线体的绝缘部分上具有至少部分可溶解的涂层。 溶解后，涂层促进组织向内生长，以将铅固定在脆弱的血管结构或其他地方。 一种这样的涂层的溶解释放治疗剂，例如改变组织向内生长的纤维化瘢痕组织含量的类固醇，使得组织和引线之间的所得粘合力较弱，从而如果需要，铅可以容易地提取。 一个这样的引线包括至少承载的绝缘细长体。 引线还包括在外周远端引线表面的绝缘部分上的至少部分可溶解的涂层。 在暴露于含水物质之后，涂层提供粗糙表面，多孔表面或溶胀表面中的一种或多种。

    Expandable seal for use with medical device and system
    10.
    发明授权
    Expandable seal for use with medical device and system 有权
    用于医疗设备和系统的可扩展密封件

    公开(公告)号：US06240321B1

    公开(公告)日：2001-05-29

    申请号：US09133310

    申请日：1998-08-12

    申请人： Aaron W. Janke ,  Larry L. Hum ,  Randy Westlund ,  Ronald W. Heil, Jr. ,  Bruce Tockman

    发明人： Aaron W. Janke ,  Larry L. Hum ,  Randy Westlund ,  Ronald W. Heil, Jr. ,  Bruce Tockman

    IPC分类号： A61N105

    CPC分类号： A61N1/0573 ,  A61N1/0565

    摘要： A seal adapted for use with medical devices is provided with a lead having a distal tip electrode. The distal tip of the lead is adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead can include a fixation helix for securing the electrode to cardiac tissue. The lead assembly can alternatively include an open lumen lead tip. A seal is provided within the lead tip assembly such that the seal is expanded to prevent or limit further entry of fluids through the lead tip. The seal includes an expandable matrix, such as a hydrogel. The seal is formed on or within the lead when the lead and the seal comes into contact with a fluid and expands. The seal is also formed as a plug which is deployed through the medical device, and expands as the plug absorbs fluid. A housing incorporating the seal can also be attached to a portion of the medical device to provide the seal.

    摘要翻译： 适于与医疗装置一起使用的密封件设置有具有远端尖端电极的引线。 引线的远端适于植入在心脏上或其周围，并用于连接到用于监测或刺激心脏活动的系统。 引线可以包括用于将电极固定到心脏组织的固定螺旋。 导线组件可以替代地包括开放的管腔引线端头。 在引线端头组件内设置密封件，使得密封件被膨胀以防止或限制流体进一步通过引线头进入。 密封件包括可膨胀基质，例如水凝胶。 当铅和密封件与流体接触并膨胀时，密封件形成在引线上或内部。 密封件还形成为通过医疗装置展开的塞子，并且当塞子吸收流体时膨胀。 结合密封件的壳体也可以附接到医疗装置的一部分以提供密封。