公开(公告)号：US07038077B2

公开(公告)日：2006-05-02

申请号：US10465972

申请日：2002-01-09

申请人： Anne Hollins Dantzig ,  James Allen Monn ,  Stephanie Ann Sweetana ,  Ana Belen Bueno Melendo ,  Alfonso De Dios ,  Carmen Dominguez-Fernandez ,  Marc Francis Herin ,  Luisa Maria Martin-Cabrejas ,  Jose Alfredo Martin ,  Maria Angeles Martinez-Grau ,  Carlos Montero Salgado ,  Concepcion Pedregal-Tercero

发明人： Anne Hollins Dantzig ,  James Allen Monn ,  Stephanie Ann Sweetana ,  Ana Belen Bueno Melendo ,  Alfonso De Dios ,  Carmen Dominguez-Fernandez ,  Marc Francis Herin ,  Luisa Maria Martin-Cabrejas ,  Jose Alfredo Martin ,  Maria Angeles Martinez-Grau ,  Carlos Montero Salgado ,  Concepcion Pedregal-Tercero

IPC分类号： C07C61/12

CPC分类号： C07C237/22 ,  A61K31/195 ,  A61K38/00 ,  A61K39/00 ,  C07C237/14 ,  C07C237/20 ,  C07C271/22 ,  C07C2602/18 ,  C07D207/16 ,  C07D209/18 ,  C07K5/06026 ,  C07K5/06034 ,  C07K5/06043 ,  C07K5/06052 ,  C07K5/0606 ,  C07K5/06078 ,  C07K5/06086 ,  C07K5/06104 ,  C07K5/06113 ,  C07K5/06191 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/1008

摘要： This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psychiatric disorders.

摘要翻译： 本发明涉及合成兴奋性氨基酸前药及其制备方法。 本发明进一步涉及使用和药物组合物的方法，其包含用于治疗神经障碍和精神障碍的化合物。

公开(公告)号：US07709444B2

公开(公告)日：2010-05-04

申请号：US11103798

申请日：2005-04-11

申请人： Nathaniel Milton ,  Kenneth Philip Moder ,  James Lawrence Sabatowski ,  Stephanie Ann Sweetana

发明人： Nathaniel Milton ,  Kenneth Philip Moder ,  James Lawrence Sabatowski ,  Stephanie Ann Sweetana

IPC分类号： A61K38/12

CPC分类号： A61K31/407 ,  A61K9/1075 ,  A61K9/19 ,  A61K38/12 ,  Y02A50/409

摘要： Pharmaceutical formulations are described comprising an echinocandin compound or echinocandin/carbohydrate complex and a pharmaceutically acceptable micelle-forming surfactant in a non-toxic aqueous solvent such that the solubilization of the echinocandin compound is optimized and the ability to freeze-dry the solution is maintained. Both the solution and freeze-dried formulations have increased stability. A bulking agent, tonicity agent buffer and/or a stabilizing agent may optionally be added to the formulations to further enhance the stability of the formulation.

摘要翻译： 描述了药物制剂，其在非毒性水性溶剂中包含棘皮菌素化合物或棘孢菌素/碳水化合物复合物和药学上可接受的胶束形成性表面活性剂，使得棘孢菌素化合物的溶解得到优化并且保持溶液冷冻干燥的能力。 溶液和冷冻干燥制剂都具有增加的稳定性。 可以任选地将配料剂，张度剂缓冲剂和/或稳定剂加入制剂中以进一步提高制剂的稳定性。

公开(公告)号：US06960564B2

公开(公告)日：2005-11-01

申请号：US09942431

申请日：2001-08-29

申请人： Nathaniel Milton ,  Kenneth Philip Moder ,  James Lawrence Sabatowski ,  Stephanie Ann Sweetana

发明人： Nathaniel Milton ,  Kenneth Philip Moder ,  James Lawrence Sabatowski ,  Stephanie Ann Sweetana

IPC分类号： A61K9/08 ,  A61K9/107 ,  A61K9/19 ,  A61K31/407 ,  A61K38/00 ,  A61K38/12 ,  A61P31/10

CPC分类号： A61K31/407 ,  A61K9/1075 ,  A61K9/19 ,  A61K38/12 ,  Y02A50/409

摘要： Pharmaceutical formulations are described comprising an echinocandin compound or echinocandin/carbohydrate complex and a pharmaceutically acceptable micelle-forming surfactant in a non-toxic aqueous solvent such that the solubilization of the echinocandin compound is optimized and the ability to freeze-dry the solution is maintained. Both the solution and freeze-dried formulations have increased stability. A bulking agent, tonicity agent buffer and/or a stabilizing agent may optionally be added to the formulations to further enhance the stability of the formulation.