公开(公告)号：US20130023022A1

公开(公告)日：2013-01-24

申请号：US13545343

申请日：2012-07-10

申请人： Anneli Nilsson ,  Gunnar Lidén ,  Marie-Francoise Gorwa-Grauslund ,  Barbel Hahn-Hägerdal ,  Carl Tobias Modig ,  Joao Ricardo Moreira De Almeida

发明人： Anneli Nilsson ,  Gunnar Lidén ,  Marie-Francoise Gorwa-Grauslund ,  Barbel Hahn-Hägerdal ,  Carl Tobias Modig ,  Joao Ricardo Moreira De Almeida

IPC分类号： C12N1/19 ,  C12P7/10

CPC分类号： C12N9/0006 ,  C12N9/1205 ,  C12N9/92 ,  C12P7/10 ,  C12P17/04 ,  Y02E50/16 ,  Y02E50/17

摘要： The present invention relates to an ethanol producing microbial strain, such as Saccharomyces cerevisiae strain, being able to grow and produce ethanol from lignocellulosic hydrolysates comprising growth inhibiting compounds of the group furfural and 5-hydroxy-methyl furfural, in a batch, fed-batch or continuous fermentation, said microbial strain being tolerant to such inhibiting compounds, which strain is upregulated and/or over expressed with regard to one or more of the following genes: LAT1, ALD6, ADH5, ADH6, GDH3, OYE3, SER3, GND2, MDH2, IDP3, ADH7, AAD15, ERG27, HMG1, LYS5, SPS19, SGE1.

公开(公告)号：US20130023021A1

公开(公告)日：2013-01-24

申请号：US13545301

申请日：2012-07-10

申请人： Anneli Nilsson ,  Gunnar Lidén ,  Marie-Francoise Gorwa-Grauslund ,  Bärbel Hahn-Hägerdal ,  Carl Tobias Modig ,  Joao Ricardo Moreira De Almeida

发明人： Anneli Nilsson ,  Gunnar Lidén ,  Marie-Francoise Gorwa-Grauslund ,  Bärbel Hahn-Hägerdal ,  Carl Tobias Modig ,  Joao Ricardo Moreira De Almeida

IPC分类号： C12P7/10 ,  C12N1/16

CPC分类号： C12N9/0006 ,  C12N9/1205 ,  C12N9/92 ,  C12P7/10 ,  C12P17/04 ,  Y02E50/16 ,  Y02E50/17

摘要： The present invention relates to an ethanol producing microbial strain, such as Saccharomyces cerevisiae strain, being able to grow and produce ethanol from lignocellulosic hydrolysates comprising growth inhibiting compounds of the group furfural and 5-hydroxy-methyl furfural, in a batch, fed-batch or continuous fermentation, said microbial strain being tolerant to such inhibiting compounds, which strain is upregulated and/or over expressed with regard to one or more of the following genes: LAT1, ALD6, ADH5, ADH6, GDH3, OYE3, SER3, GND2, MDH2, IDP3, ADH7, AAD15, ERG27, HMG1, LYS5, SPS19, SGE1.

公开(公告)号：US20090061502A1

公开(公告)日：2009-03-05

申请号：US12201292

申请日：2008-08-29

申请人： Anneli Nilsson ,  Gunnar Liden ,  Marie-Francoise Gorwa-Grauslund ,  Barbel Hahn-Hagerdal ,  Carl Tobias Modig ,  Joao Ricardo Moreira De Almeida

发明人： Anneli Nilsson ,  Gunnar Liden ,  Marie-Francoise Gorwa-Grauslund ,  Barbel Hahn-Hagerdal ,  Carl Tobias Modig ,  Joao Ricardo Moreira De Almeida

IPC分类号： C12N1/16

CPC分类号： C12N9/0006 ,  C12N9/1205 ,  C12N9/92 ,  C12P7/10 ,  C12P17/04 ,  Y02E50/16 ,  Y02E50/17

摘要： The present invention relates to an ethanol producing microbial strain, such as Saccharomyces cerevisiae strain, being able to grow and produce ethanol from lignocellulosic hydrolysates comprising growth inhibiting compounds of the group furfural and 5-hydroxy-methyl furfural, in a batch, fed-batch or continuous fermentation, said microbial strain being tolerant to such inhibiting compounds, which strain is upregulated and/or over expressed with regard to one or more of the following genes: LAT1, ALD6, ADH5, ADH6, GDH3, OYE3, SER3, GND2, MDH2, IDP3, ADH7, AAD15, ERG27, HMG1, LYS5, SPS19, SGE1.

摘要翻译： 本发明涉及一种生产乙醇的微生物菌株，例如酿酒酵母菌株，能够从包含糠醛和5-羟甲基糠醛的生长抑制化合物的木质纤维素水解产物中分批生产和生产乙醇，补料分批 或连续发酵，所述微生物菌株对这种抑制化合物是耐受的，该菌株对于以下一个或多个基因：上调和/或过度表达：LAT1，ALD6，ADH5，ADH6，GDH3，OYE3，SER3，GND2， MDH2，IDP3，ADH7，AAD15，ERG27，HMG1，LYS5，SPS19，SGE1。