公开(公告)号：US6130075A

公开(公告)日：2000-10-10

申请号：US296255

申请日：1999-04-22

申请人： Jordi Planas ,  Folke Tjerneld ,  Barbel Hahn-Hagerdal

发明人： Jordi Planas ,  Folke Tjerneld ,  Barbel Hahn-Hagerdal

IPC分类号： C07C51/48 ,  C12P7/00 ,  C12P7/40 ,  C12P7/48 ,  C12P7/56

CPC分类号： C07C51/48

摘要： The invention provides novel polymer conjugates that are especially useful in the separation of carboxylic acids from complex fermentation compositions. The polymer conjugates comprise polyethylene glycols or oxides and polyethyleneimine or polypropyleneimine in various ratios. The novel polymer conjugates permit enhanced extraction of carboxylic acids from fermentation systems not only through their use in partitioning the carboxylic acids from various polymeric components of the fermentation system, but also through their use in adjusting the pH of the system for optimal performance and separation.

摘要翻译： 本发明提供了新颖的聚合物共轭物，其特别可用于从复合发酵组合物中分离羧酸。 聚合物共轭物包括各种比例的聚乙二醇或氧化物和聚乙烯亚胺或聚丙烯亚胺。 新型聚合物共轭物允许从发酵系统中增强羧酸的提取，不仅通过其用于从发酵系统的各种聚合物组分分配羧酸，而且还通过其用于调节系统的pH以获得最佳性能和分离。

公开(公告)号：US20090311771A1

公开(公告)日：2009-12-17

申请号：US11852400

申请日：2007-09-10

申请人： Eckhard Boles ,  Barbel Hahn-Hagerdal ,  Marie-Francoise Gorwa-Grauslund ,  Kaisa Karhumaa ,  Beate Wiedemann

发明人： Eckhard Boles ,  Barbel Hahn-Hagerdal ,  Marie-Francoise Gorwa-Grauslund ,  Kaisa Karhumaa ,  Beate Wiedemann

IPC分类号： C12N1/19

CPC分类号： C12R1/865 ,  C12N1/18 ,  C12N15/52 ,  C12P7/08

摘要： The present invention relates to a S. cerevisiae strain expressing both arabinose and xylose utilization pathways, and in particular to a S. cerevisiae strain fermenting both arabinose and xylose to ethanol, and more particularly a S. cerevisiae strain with overexpression or upregulation of xylose- or aldose reductase (XR, AR) with xylitol dehydrogenase (XDH) together with overexpression or upregulation of genes forming an arabinose utilization pathway. The invention encompasses both laboratory and industrial strain having these properties.

摘要翻译： 本发明涉及表达阿拉伯糖和木糖利用途径的酿酒酵母菌株，特别涉及发酵阿拉伯糖和木糖至乙醇的酿酒酵母菌株，更具体地涉及具有过表达或上调木糖转化酶的酿酒酵母菌株， 或醛糖还原酶（XR，AR）与木糖醇脱氢酶（XDH）以及形成阿拉伯糖利用途径的基因的过表达或上调。 本发明包括具有这些性质的实验室和工业菌株。

公开(公告)号：US08129171B2

公开(公告)日：2012-03-06

申请号：US11852400

申请日：2007-09-10

申请人： Eckhard Boles ,  Barbel Hahn-Hagerdal ,  Marie-Francoise Gorwa-Grauslund ,  Kaisa Karhumaa ,  Beate Wiedemann

发明人： Eckhard Boles ,  Barbel Hahn-Hagerdal ,  Marie-Francoise Gorwa-Grauslund ,  Kaisa Karhumaa ,  Beate Wiedemann

IPC分类号： C12N1/15

CPC分类号： C12R1/865 ,  C12N1/18 ,  C12N15/52 ,  C12P7/08

摘要： A S. cerevisiae strain expressing both arabinose and xylose utilization pathways, and in particular to a S. cerevisiae strain fermenting both arabinose and xylose to ethanol, and more particularly a S. cerevisiae strain with overexpression or upregulation of xylose- or aldose reductase (XR, AR) with xylitol dehydrogenase (XDH) together with overexpression or upregulation of genes forming an arabinose utilization pathway. The invention encompasses both laboratory and industrial strain having these properties.

摘要翻译： 表达阿拉伯糖和木糖利用途径的酿酒酵母菌株，特别是发酵阿拉伯糖和木糖至乙醇的啤酒酵母菌株，更特别是具有过表达或上调木糖或醛糖还原酶（XR）的酿酒酵母菌株 ，AR）与木糖醇脱氢酶（XDH）一起，以及形成阿拉伯糖利用途径的基因的过表达或上调。 本发明包括具有这些性质的实验室和工业菌株。

公开(公告)号：US20090061502A1

公开(公告)日：2009-03-05

申请号：US12201292

申请日：2008-08-29

申请人： Anneli Nilsson ,  Gunnar Liden ,  Marie-Francoise Gorwa-Grauslund ,  Barbel Hahn-Hagerdal ,  Carl Tobias Modig ,  Joao Ricardo Moreira De Almeida

发明人： Anneli Nilsson ,  Gunnar Liden ,  Marie-Francoise Gorwa-Grauslund ,  Barbel Hahn-Hagerdal ,  Carl Tobias Modig ,  Joao Ricardo Moreira De Almeida

IPC分类号： C12N1/16

CPC分类号： C12N9/0006 ,  C12N9/1205 ,  C12N9/92 ,  C12P7/10 ,  C12P17/04 ,  Y02E50/16 ,  Y02E50/17

摘要： The present invention relates to an ethanol producing microbial strain, such as Saccharomyces cerevisiae strain, being able to grow and produce ethanol from lignocellulosic hydrolysates comprising growth inhibiting compounds of the group furfural and 5-hydroxy-methyl furfural, in a batch, fed-batch or continuous fermentation, said microbial strain being tolerant to such inhibiting compounds, which strain is upregulated and/or over expressed with regard to one or more of the following genes: LAT1, ALD6, ADH5, ADH6, GDH3, OYE3, SER3, GND2, MDH2, IDP3, ADH7, AAD15, ERG27, HMG1, LYS5, SPS19, SGE1.

摘要翻译： 本发明涉及一种生产乙醇的微生物菌株，例如酿酒酵母菌株，能够从包含糠醛和5-羟甲基糠醛的生长抑制化合物的木质纤维素水解产物中分批生产和生产乙醇，补料分批 或连续发酵，所述微生物菌株对这种抑制化合物是耐受的，该菌株对于以下一个或多个基因：上调和/或过度表达：LAT1，ALD6，ADH5，ADH6，GDH3，OYE3，SER3，GND2， MDH2，IDP3，ADH7，AAD15，ERG27，HMG1，LYS5，SPS19，SGE1。

公开(公告)号：US5866382A

公开(公告)日：1999-02-02

申请号：US336198

申请日：1994-11-03

申请人： Johan Hallborn ,  Merja Penttila ,  Heikki Ojamo ,  Mats Walfridsson ,  Ulla Airaksinen ,  Sirkka Keranen ,  Barbel Hahn-Hagerdal

发明人： Johan Hallborn ,  Merja Penttila ,  Heikki Ojamo ,  Mats Walfridsson ,  Ulla Airaksinen ,  Sirkka Keranen ,  Barbel Hahn-Hagerdal

IPC分类号： C12N1/15 ,  C12N1/19 ,  C12N9/02 ,  C12N9/04 ,  C12N15/52 ,  C12N15/81 ,  C12N15/90 ,  C12P7/06 ,  C12P7/18 ,  C12P7/40 ,  C12P19/02 ,  C12P7/02

CPC分类号： C12P19/02 ,  C12N15/52 ,  C12N15/81 ,  C12N15/905 ,  C12N9/0004 ,  C12N9/0006 ,  C12P7/06 ,  C12P7/18 ,  C12P7/40 ,  Y02E50/17 ,  Y02P20/582

摘要： This invention relates to recombinant-DNA-technology. Specifically, this invention relates to new recombinant yeast strains transformed with xylose reductase and/or xylitol dehydrogenase enzyme genes. A yeast strain transformed with the xylose reductase gene is capable of reducing xylose to xylitol and consequently of producing xylitol in vivo. If both of these genes are transformed into a yeast strain, the resultant strain is capable of producing ethanol on xylose containing medium during fermentation. Further, the said new yeast strains are capable of expressing the said two enzymes. Xylose reductase produced by these strains can be used in an enzymatic process for the production of xylitol in vitro.

摘要翻译： 本发明涉及重组DNA技术。 具体地，本发明涉及用木糖还原酶和/或木糖醇脱氢酶基因转化的新的重组酵母菌株。 用木糖还原酶基因转化的酵母菌株能够将木糖还原成木糖醇，从而在体内产生木糖醇。 如果将这两个基因转化成酵母菌株，则所得菌株能够在发酵期间在含有木糖的培养基上产生乙醇。 此外，所述新酵母菌株能够表达所述两种酶。 由这些菌株产生的木糖还原酶可用于体外生产木糖醇的酶法。