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公开(公告)号：US06737410B1
公开(公告)日：2004-05-18
申请号：US09678554
申请日：2000-10-04
IPC分类号： C07K506
CPC分类号： C07K5/06139 , C07K5/06191
摘要： The present invention provides compounds having the structure represented by Formula I: and methods of treating cancer, restenosis, atherosclerosis, or psoriasis or preventing restenosis, and a pharmaceutical composition comprising a compound of Formula I and a pharmaceutically acceptable carrier.
摘要翻译： 本发明提供具有由式I表示的结构的化合物以及治疗癌症，再狭窄，动脉粥样硬化或银屑病或预防再狭窄的方法，以及包含式I化合物和药学上可接受的载体的药物组合物。
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公开(公告)号：US06265382B1
公开(公告)日：2001-07-24
申请号：US09331876
申请日：1999-06-28
IPC分类号： C07K506
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/06147
摘要： The present invention provides compounds having the structure represented by formula (I). Also provided is a method of treating cancer, restenosis, atherosclerosis, or psoriasis or preventing restenosis, and a pharmaceutical composition comprising a compound of formula (I).
摘要翻译： 本发明提供具有由式（I）表示的结构的化合物。 还提供了治疗癌症，再狭窄，动脉粥样硬化或牛皮癣或预防再狭窄的方法，以及包含式（I）化合物的药物组合物。
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3.发明授权Functionalized alkyl and alenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors 失效甘氨酰胺的官能化烷基和烯丙基侧链衍生物作为法呢基转移酶抑制剂公开(公告)号：US06369034B1
公开(公告)日：2002-04-09
申请号：US09646147
申请日：2000-09-13
申请人： Annette Marian Doherty , James Stanley Kaltenbronn , Daniele Marie Leonard , Dennis Joseph McNamara , John Quin, III
发明人： Annette Marian Doherty , James Stanley Kaltenbronn , Daniele Marie Leonard , Dennis Joseph McNamara , John Quin, III
IPC分类号： A61K3805
CPC分类号： C07K5/06147 , A61K38/00
摘要： The present invention provides compounds of Formula (I). The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula (I).
摘要翻译： 本发明提供式（I）的化合物。 本发明还提供了治疗癌症和治疗或预防再狭窄或动脉粥样硬化的方法。 本发明还提供含有式（I）化合物的药学上可接受的组合物。
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公开(公告)号：US6143766A
公开(公告)日：2000-11-07
申请号：US488437
申请日：2000-01-20
IPC分类号： C07D401/12 , C07D405/12 , C07D521/00 , A61K31/47 , A61K31/415 , C07D215/16 , C07D233/02
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D401/12 , C07D405/12
摘要： The present invention provides ras farnesyl transferase inhibiting compounds of Formula I ##STR1## The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula I.
摘要翻译： 本发明提供了Ras法呢基转移酶抑制的式I化合物本发明还提供了治疗癌症和治疗或预防再狭窄或动脉粥样硬化的方法。 本发明还提供了含有式I化合物的药学上可接受的组合物。
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公开(公告)号：US06943183B2
公开(公告)日：2005-09-13
申请号：US10257301
申请日：2001-04-16
申请人： William Alexander Denny , Richard H. Hutchings , Douglas S. Johnson , James Stanley Kaltenbronn , Ho Huat Lee , Daniele Marie Leonard , Jared Bruce John Milbank , Joseph Thomas Repine , Gordon William Rewcastle , Andrew David White
发明人： William Alexander Denny , Richard H. Hutchings , Douglas S. Johnson , James Stanley Kaltenbronn , Ho Huat Lee , Daniele Marie Leonard , Jared Bruce John Milbank , Joseph Thomas Repine , Gordon William Rewcastle , Andrew David White
IPC分类号： C07D233/60 , A61K31/4164 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/4725 , A61K31/496 , A61K31/497 , A61P9/10 , A61P13/00 , A61P13/08 , A61P17/06 , A61P27/02 , A61P31/12 , A61P35/00 , A61P43/00 , C07D233/54 , C07D233/91 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14 , C07D521/00 , C07D233/64
CPC分类号： C07D233/64 , C07D231/12 , C07D233/56 , C07D233/91 , C07D249/08 , C07D401/12
摘要： The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme
摘要翻译： 本发明提供式I，II，III和IV的新型5-取代四氢萘酮及其药学上可接受的盐，酯，酰胺和前药，其可用于治疗和预防组织如癌症的不受控制或异常增殖， 动脉粥样硬化，再狭窄和牛皮癣。 具体地，本发明涉及抑制法呢基转移酶的化合物
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