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7 条记录 (耗时 0.038 秒)

    3,7-Diazabicyclo [3.3.1] formulations as anti-arrhythmic compounds
    3.
    发明授权
    3,7-Diazabicyclo [3.3.1] formulations as anti-arrhythmic compounds 失效
    3,7-二氮杂双环[3.3.1]制剂作为抗心律失常化合物

    公开(公告)号：US07217708B2

    公开(公告)日：2007-05-15

    申请号：US10474592

    申请日：2002-04-12

    申请人： Neil Barnwell ,  Annika Björe ,  Lal Cheema ,  David Cladingboel ,  Adam Herring ,  Karin Lövqvist

    发明人： Neil Barnwell ,  Annika Björe ,  Lal Cheema ,  David Cladingboel ,  Adam Herring ,  Karin Lövqvist

    IPC分类号： C07D498/08 ,  A61K31/5386

    CPC分类号： C07D498/08

    摘要： There is provided substantially crystalline forms of 4-({3-[7-(3,3-dimethyl-2-oxobutyl) -9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl]propyl}amino)benzo-nitrile; tert-butyl 2 -{7-[3-(4-cyanoanilino)propyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate; tert-butyl 2-{7-[4-(4-cyanophenyl)butyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethylcarbamate; or tert-butyl 2-{7-[2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl}ethylcarbamate and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of cardiac arhythmias.

    摘要翻译： 提供4 - （{3- [7-（3,3-二甲基-2-氧代丁基）-9-氧杂-3,7-二氮杂双环[3.3.1]壬-3-基]丙基} 氨基）苯并 - 腈; 2- {7- [3-（4-氰基苯胺基）丙基] -9-氧杂-3,7-二氮杂双环[3.3.1]壬-3-基}乙基氨基甲酸叔丁酯; 2- {7- [4-（4-氰基苯基）丁基] -9-氧杂-3,7-二氮杂双环[3.3.1]壬-3-基}乙基氨基甲酸叔丁酯; 或2- {7- [2S）-3-（4-氰基苯氧基）-2-羟丙基] -9-氧杂-3,7-二氮杂双环[3.3.1]壬-3-基}乙基氨基甲酸叔丁酯和药学上 其可接受的盐，其可用于治疗心律失常。

    Dried or frozen pharmaceutical preparation containing a class III antiarrhythmic compound
    7.
    发明授权
    Dried or frozen pharmaceutical preparation containing a class III antiarrhythmic compound 失效
    含有III类抗心律失常药物的干燥或冷冻药物制剂

    公开(公告)号：US06492382B1

    公开(公告)日：2002-12-10

    申请号：US09423200

    申请日：1999-11-03

    申请人： Annika Björe ,  Anna-Karin Granath

    发明人： Annika Björe ,  Anna-Karin Granath

    IPC分类号： A61K31439

    CPC分类号： C07D471/08 ,  A61K9/19 ,  A61K31/439 ,  Y10S514/821

    摘要： The present invention relates to dried preparations containing a class III antiarrhythmic compound in the form of a crystalline or amorphous salt or any combination thereof, where the counterion is selected from pharmaceutically acceptable water-soluble organic or inorganic acids. The present invention also relates to frozen preparations containing a class III antiarrhythmic compound in the form of a salt solution, where the counterion is selected from pharmaceutically acceptable water-soluble organic or inorganic acids. Preferred preparations contain a salt of the compound 3,7-diazabicyclo[3.3.1]-nonane-3-carboxylic acid, 7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-1,1-dimethylethyl ester (Compound A). Further aspects of the present invention include salts of Compound A per se, processes for preparing the preparations, as well as use of the preparations for prophylaxis and/or treatment of cardiac arrhytmia.

    摘要翻译： 本发明涉及含有结晶或无定形盐或其任何组合形式的III类抗心律失常化合物的干燥制剂，其中抗衡离子选自药学上可接受的水溶性有机酸或无机酸。 本发明还涉及含有盐溶液形式的III类抗心律失常化合物的冷冻制剂，其中抗衡离子选自药学上可接受的水溶性有机酸或无机酸。 优选的制剂含有化合物3,7-二氮杂双环[3.3.1] - 壬烷-3-羧酸，7 - [（2S）-3-（4-氰基苯氧基）-2-羟丙基] 二甲基乙基酯（化合物A）。 本发明的其它方面包括化合物A本身的盐，制备方法，以及用于预防和/或治疗心脏性心律的制剂。