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    Agents that bind a target in pulmonary tissue for targeting respiratory diseases
    10.
    发明授权
    Agents that bind a target in pulmonary tissue for targeting respiratory diseases 有权
    结合肺组织中靶标以靶向呼吸道疾病的药剂

    公开(公告)号：US08129503B2

    公开(公告)日：2012-03-06

    申请号：US12084084

    申请日：2006-10-23

    申请人： Rudolf M. T. de Wildt ,  Steve Holmes ,  Ian M. Tomlinson ,  Gregory P. Winter ,  Mary F. Fitzgerald ,  Justian Craig Fox ,  Armin Sepp ,  Jennifer Luckett ,  Benjamin P. Woolven

    发明人： Rudolf M. T. de Wildt ,  Steve Holmes ,  Ian M. Tomlinson ,  Gregory P. Winter ,  Mary F. Fitzgerald ,  Justian Craig Fox ,  Armin Sepp ,  Jennifer Luckett ,  Benjamin P. Woolven

    IPC分类号： C07K16/00

    CPC分类号： C07K16/2875 ,  A61K9/0043 ,  A61K9/007 ,  A61K39/3955 ,  C07K16/28 ,  C07K16/2878 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/76

    摘要： Disclosed is the use of an agent (e.g., antibody fragment, antagonist, ligand, dAb monomer) that binds a target in pulmonary tissue for the manufacture of a long action or long therapeutic window formulation for local delivery to pulmonary tissue, and methods for administering an agent that binds a target in pulmonary tissue to a subject to produce a long therapeutic window in pulmonary tissue. The formulation is for, and the method comprises, administering locally to pulmonary tissue. Also disclosed is the use of antagonists of TNFR1 for the manufacture of a formulation or medicament for treating, preventing or suppressing lung inflammation or a respiratory disease, and methods of treating such diseases. Also disclosed are the use of agents a for the manufacture of a delivery device (e.g., inhaler, intranasal delivery device) for the treatment or prevention of lung inflammation or a respiratory disease, and a delivery device for the treatment or prevention of lung inflammation or a respiratory disease that contains an agent as described herein.

    摘要翻译： 公开了结合肺组织中的靶标以制备用于局部递送至肺组织的长效或长治疗窗口制剂的试剂（例如，抗体片段，拮抗剂，配体，dAb单体）的用途，以及用于施用 将肺组织中的靶标结合到受试者以在肺组织中产生长治疗窗的药剂。 该制剂用于，并且该方法包括局部给予肺组织。 还公开了使用TNFR1的拮抗剂来制造用于治疗，预防或抑制肺部炎症或呼吸系统疾病的制剂或药物，以及治疗这些疾病的方法。 还公开了使用试剂a来制造用于治疗或预防肺部炎症或呼吸系统疾病的输送装置（例如，吸入器，鼻内递送装置），以及用于治疗或预防肺部炎症或 包含本文所述的药剂的呼吸系统疾病。