公开(公告)号：US20120083718A1

公开(公告)日：2012-04-05

申请号：US13209408

申请日：2011-08-14

申请人： Anthony J. Alleman ,  William Barnard ,  Randal Lee Radford

发明人： Anthony J. Alleman ,  William Barnard ,  Randal Lee Radford

IPC分类号： A61N7/00

CPC分类号： A61N7/00 ,  A61B8/4427 ,  A61B2017/00734 ,  A61N2007/0078 ,  A61N2007/0095

摘要： Disclosed is a “hands-free”, autonomously operating, battery-powered apparatus with electronic programmable actuation circuitry for non-invasive ultrasonic treatment of ischemic stroke, microatheromas of the cerebral vasculature, intracranial hypertension, and other cerebrovascular pathologies such as hypoperfusion associated with migraine. The apparatus is provided with registration members to facilitate stereotactic placement of the headset on the skull with respect to target intracranial anatomy. Once fitted in place on the skull and activated, the device does not require clinical intervention during operation; does not need skilled technical adjustment of the waveform patterns; and achieves therapeutic results with power consumption of less than 400 mAmp-hr, thus permitting extended portable operation without external power and eliminating the need for assisted cooling. Using a device of the invention, transcranial ultrasound may be self-administered. The device has application in therapeutic methods, such as methods for treating stroke or migraine, for non-invasively augmenting drug action, and for release or dispersal of endogenous neurovascular mediators.

摘要翻译： 公开了一种“免提”自主操作的电池供电装置，其具有用于非侵入性超声治疗缺血性卒中的电子可编程驱动电路，脑血管系统的微动脉，颅内高压和其他脑血管病变，例如与偏头痛相关的灌注不足 。 该装置设置有对准构件，以有助于相对于目标颅内解剖结构将耳机的立体定位放置在头骨上。 一旦安装在颅骨上的位置并被激活，该装置在手术期间不需要临床干预; 不需要熟练的技术调整波形图案; 并实现功耗小于400 mAmp-hr的治疗效果，从而延长便携操作而无需外部电源，无需辅助冷却。 使用本发明的装置，经颅超声可以是自我施用的。 该装置可用于治疗方法，例如治疗中风或偏头痛的方法，用于非侵入性增加药物作用，以及释放或分散内源性神经血管介质。

公开(公告)号：US08603014B2

公开(公告)日：2013-12-10

申请号：US13209408

申请日：2011-08-14

申请人： Anthony John Alleman ,  William Barnard ,  Randal Lee Radford

发明人： Anthony John Alleman ,  William Barnard ,  Randal Lee Radford

IPC分类号： A61H1/00

CPC分类号： A61N7/00 ,  A61B8/4427 ,  A61B2017/00734 ,  A61N2007/0078 ,  A61N2007/0095

摘要： Disclosed is a “hands-free”, autonomously operating, battery-powered apparatus with electronic programmable actuation circuitry for non-invasive ultrasonic treatment of ischemic stroke, microatheromas of the cerebral vasculature, intracranial hypertension, and other cerebrovascular pathologies such as hypoperfusion associated with migraine. The apparatus is provided with registration members to facilitate stereotactic placement of the headset on the skull with respect to target intracranial anatomy. Once fitted in place on the skull and activated, the device does not require clinical intervention during operation; does not need skilled technical adjustment of the waveform patterns; and achieves therapeutic results with power consumption of less than 400 mAmp-hr, thus permitting extended portable operation without external power and eliminating the need for assisted cooling. Using a device of the invention, transcranial ultrasound may be self-administered. The device has application in therapeutic methods, such as methods for treating stroke or migraine, for non-invasively augmenting drug action, and for release or dispersal of endogenous neurovascular mediators.

摘要翻译： 公开了一种“免提”自主操作的电池供电装置，其具有用于非侵入性超声治疗缺血性卒中的电子可编程驱动电路，脑血管系统的微动脉，颅内高压和其他脑血管病变，例如与偏头痛相关的灌注不足 。 该装置设置有对准构件，以便于相对于目标颅内解剖结构将耳机的立体定向放置在头骨上。 一旦安装在颅骨上的位置并被激活，该装置在手术期间不需要临床干预; 不需要熟练的技术调整波形图案; 并实现功耗小于400 mAmp-hr的治疗效果，从而延长便携操作而无需外部电源，无需辅助冷却。 使用本发明的装置，经颅超声可以是自我施用的。 该装置可用于治疗方法，例如治疗中风或偏头痛的方法，用于非侵入性增加药物作用，以及释放或分散内源性神经血管介质。