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公开(公告)号：US20120093889A1
公开(公告)日：2012-04-19
申请号：US13330395
申请日：2011-12-19
申请人： Anthony McKinney , Gary Tollefson , Eckard Weber , Rick Soltero
发明人： Anthony McKinney , Gary Tollefson , Eckard Weber , Rick Soltero
IPC分类号： A61K9/00 , A61K31/485 , A61K31/423 , A61P3/04
CPC分类号： A61K9/209 , A61K9/0002 , A61K9/2018 , A61K9/2054 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/35 , A61K31/357 , A61K31/42 , A61K31/423 , A61K31/485 , A61K31/551 , A61K31/5513 , A61K45/06 , A61K47/26 , A61K2300/00
摘要： In one embodiment a layered pharmaceutical formulation includes two or more pharmaceutical layers and an intermediate layer disposed between at least two of the two or more pharmaceutical layers, the intermediate layer configured to dissolve in vivo to thereby leave the two or more pharmaceutical layers substantially intact. In one embodiment, an active pharmaceutical ingredient in at least one of the pharmaceutical layers is selected from bupropion, zonisamide, naltrexone, topiramate, phentermine, metformin, olanzapine and fluoxetine.
摘要翻译： 在一个实施方案中，分层药物制剂包含两个或更多个药物层和设置在两个或更多个药物层中的至少两个之间的中间层，所述中间层被配置为在体内溶解，从而使两个或更多个药物层基本上保持完好。 在一个实施方案中，至少一个药物层中的活性药物成分选自安非他酮，唑尼沙胺，纳曲酮，托吡酯，芬特明，二甲双胍，奥氮平和氟西汀。
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公开(公告)号：US20080113026A1
公开(公告)日：2008-05-15
申请号：US11937421
申请日：2007-11-08
申请人： Anthony McKinney , Gary Tollefson , Eckard Weber , Rick Soltero
发明人： Anthony McKinney , Gary Tollefson , Eckard Weber , Rick Soltero
IPC分类号： A61K9/24
CPC分类号： A61K9/209 , A61K9/0002 , A61K9/2018 , A61K9/2054 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/35 , A61K31/357 , A61K31/42 , A61K31/423 , A61K31/485 , A61K31/551 , A61K31/5513 , A61K45/06 , A61K47/26 , A61K2300/00
摘要： In one embodiment a layered pharmaceutical formulation includes two or more pharmaceutical layers and an intermediate layer disposed between at least two of the two or more pharmaceutical layers, the intermediate layer configured to dissolve in vivo to thereby leave the two or more pharmaceutical layers substantially intact. In one embodiment, an active pharmaceutical ingredient in at least one of the pharmaceutical layers is selected from bupropion, zonisamide, naltrexone, topiramate, phentermine, metformin, olanzapine and fluoxetine.
摘要翻译： 在一个实施方案中，分层药物制剂包含两个或更多个药物层和设置在两个或更多个药物层中的至少两个之间的中间层，所述中间层被配置为在体内溶解，从而使两个或更多个药物层基本上保持完好。 在一个实施方案中，至少一个药物层中的活性药物成分选自安非他酮，唑尼沙胺，纳曲酮，托吡酯，芬特明，二甲双胍，奥氮平和氟西汀。
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公开(公告)号：US08722085B2
公开(公告)日：2014-05-13
申请号：US12838364
申请日：2010-07-16
申请人： Anthony McKinney , Gary Tollefson , Eckard Weber , Rick Soltero
发明人： Anthony McKinney , Gary Tollefson , Eckard Weber , Rick Soltero
IPC分类号： A61K9/20 , A61K31/415 , A61K31/137 , A61K31/439 , A61K31/35 , A61K31/551 , A61P3/04
CPC分类号： A61K9/209 , A61J1/035 , A61J7/04 , A61J7/0454 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/35 , A61K31/42 , A61K31/423 , A61K31/485 , A61K31/551 , A61K31/5513 , A61K31/7048 , A61K45/06 , B65D75/36 , A61K2300/00
摘要： Methods and systems for administration of pharmaceuticals using a unit dosage package that includes a first unit dosage that has a first drug and a second drug, a second unit dosage that has the first drug and the second drug, where the second unit dosage includes a different amount of the second drug than the first unit dosage and a unit dosage package is configured to hold the first unit dosage and the second unit dosage. In preferred embodiments the methods and systems are used for administration of weight loss medications.
摘要翻译： 用于使用包括具有第一药物和第二药物的第一单位剂量的单位剂量包装的药物的给药方法和系统，具有第一药物和第二药物的第二单位剂量，其中第二单位剂量包括不同的 第二药物的量比第一单位剂量和单位剂量包装被配置为保持第一单位剂量和第二单位剂量。 在优选的实施方案中，所述方法和系统用于施用减肥药物。
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公开(公告)号：US20080110792A1
公开(公告)日：2008-05-15
申请号：US11937367
申请日：2007-11-08
申请人： Anthony McKinney , Gary Tollefson , Eckard Weber , Rick Soltero
发明人： Anthony McKinney , Gary Tollefson , Eckard Weber , Rick Soltero
CPC分类号： A61K9/209 , A61J1/035 , A61J7/04 , A61J7/0454 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/35 , A61K31/42 , A61K31/423 , A61K31/485 , A61K31/551 , A61K31/5513 , A61K31/7048 , A61K45/06 , B65D75/36 , A61K2300/00
摘要： Methods and systems for administration of pharmaceuticals using a unit dosage package that includes a first unit dosage that has a first drug and a second drug, a second unit dosage that has the first drug and the second drug, where the second unit dosage includes a different amount of the second drug than the first unit dosage and a unit dosage package is configured to hold the first unit dosage and the second unit dosage. In preferred embodiments the methods and systems are used for administration of weight loss medications.
摘要翻译： 用于使用包括具有第一药物和第二药物的第一单位剂量的单位剂量包装的药物的给药方法和系统，具有第一药物和第二药物的第二单位剂量，其中第二单位剂量包括不同的 第二药物的量比第一单位剂量和单位剂量包装被配置为保持第一单位剂量和第二单位剂量。 在优选的实施方案中，所述方法和系统用于施用减肥药物。
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公开(公告)号：US08318788B2
公开(公告)日：2012-11-27
申请号：US13330395
申请日：2011-12-19
申请人： Anthony McKinney , Gary Tollefson , Eckard Weber , Rick Soltero
发明人： Anthony McKinney , Gary Tollefson , Eckard Weber , Rick Soltero
IPC分类号： A61K9/00 , A61K31/485 , A61K31/423 , A61P3/04
CPC分类号： A61K9/209 , A61K9/0002 , A61K9/2018 , A61K9/2054 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/35 , A61K31/357 , A61K31/42 , A61K31/423 , A61K31/485 , A61K31/551 , A61K31/5513 , A61K45/06 , A61K47/26 , A61K2300/00
摘要： In one embodiment a layered pharmaceutical formulation includes two or more pharmaceutical layers and an intermediate layer disposed between at least two of the two or more pharmaceutical layers, the intermediate layer configured to dissolve in vivo to thereby leave the two or more pharmaceutical layers substantially intact. In one embodiment, an active pharmaceutical ingredient in at least one of the pharmaceutical layers is selected from bupropion, zonisamide, naltrexone, topiramate, phentermine, metformin, olanzapine and fluoxetine.
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公开(公告)号：US08088786B2
公开(公告)日：2012-01-03
申请号：US11937421
申请日：2007-11-08
申请人： Anthony McKinney , Gary Tollefson , Eckard Weber , Rick Soltero
发明人： Anthony McKinney , Gary Tollefson , Eckard Weber , Rick Soltero
CPC分类号： A61K9/209 , A61K9/0002 , A61K9/2018 , A61K9/2054 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/35 , A61K31/357 , A61K31/42 , A61K31/423 , A61K31/485 , A61K31/551 , A61K31/5513 , A61K45/06 , A61K47/26 , A61K2300/00
摘要： In one embodiment a layered pharmaceutical formulation includes two or more pharmaceutical layers and an intermediate layer disposed between at least two of the two or more pharmaceutical layers, the intermediate layer configured to dissolve in vivo to thereby leave the two or more pharmaceutical layers substantially intact. In one embodiment, an active pharmaceutical ingredient in at least one of the pharmaceutical layers is selected from bupropion, zonisamide, naltrexone, topiramate, phentermine, metformin, olanzapine and fluoxetine.
摘要翻译： 在一个实施方案中，分层药物制剂包含两个或更多个药物层和设置在两个或更多个药物层中的至少两个之间的中间层，所述中间层被配置为在体内溶解，从而使两个或更多个药物层基本上保持完好。 在一个实施方案中，至少一个药物层中的活性药物成分选自安非他酮，唑尼沙胺，纳曲酮，托吡酯，芬特明，二甲双胍，奥氮平和氟西汀。
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公开(公告)号：US20110059170A1
公开(公告)日：2011-03-10
申请号：US12838364
申请日：2010-07-16
申请人： Anthony McKinney , Gary Tollefson , Eckard Weber , Rick Soltero
发明人： Anthony McKinney , Gary Tollefson , Eckard Weber , Rick Soltero
IPC分类号： A61K9/20 , A61K31/415 , A61K31/137 , A61K31/439 , A61K31/35 , A61K31/551 , A61P3/04
CPC分类号： A61K9/209 , A61J1/035 , A61J7/04 , A61J7/0454 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/35 , A61K31/42 , A61K31/423 , A61K31/485 , A61K31/551 , A61K31/5513 , A61K31/7048 , A61K45/06 , B65D75/36 , A61K2300/00
摘要： Methods and systems for administration of pharmaceuticals using a unit dosage package that includes a first unit dosage that has a first drug and a second drug, a second unit dosage that has the first drug and the second drug, where the second unit dosage includes a different amount of the second drug than the first unit dosage and a unit dosage package is configured to hold the first unit dosage and the second unit dosage. In preferred embodiments the methods and systems are used for administration of weight loss medications.
摘要翻译： 用于使用包括具有第一药物和第二药物的第一单位剂量的单位剂量包装的药物的给药方法和系统，具有第一药物和第二药物的第二单位剂量，其中第二单位剂量包括不同的 第二药物的量比第一单位剂量和单位剂量包装被配置为保持第一单位剂量和第二单位剂量。 在优选的实施方案中，所述方法和系统用于施用减肥药物。
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公开(公告)号：US20070148237A1
公开(公告)日：2007-06-28
申请号：US11563618
申请日：2006-11-27
申请人： Anthony McKinney , Gary Tollefson , Simon Yau , Ronald Vladyka , Rick Soltero
发明人： Anthony McKinney , Gary Tollefson , Simon Yau , Ronald Vladyka , Rick Soltero
CPC分类号： A61K31/423 , A61K9/0002 , A61K9/1652 , A61K9/2018 , A61K9/2054 , A61K9/2077 , A61K9/5084 , A61K31/137 , A61K31/42 , A61K31/485
摘要： Pharmaceutical formulations comprise sustained-release zonisamide. Methods of preparing such pharmaceutical formulations involve intermixing zonisamide with a suitable excipient configured to control the dissolution profile of the zonisamide. Methods of treatment involve administering the pharmaceutical formulations to patients in need of such treatment.
摘要翻译： 药物制剂包含缓释唑尼沙胺。 制备这种药物制剂的方法包括将唑尼沙胺与配制成控制唑尼沙胺的溶出曲线的合适赋形剂混合。 治疗方法包括向需要这种治疗的患者施用药物制剂。
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