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    Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivates and their uses
    4.
    发明申请
    Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivates and their uses 失效
    含有三环二萜及其衍生物及其用途的膳食和药物组合物

    公开(公告)号：US20100099753A1

    公开(公告)日：2010-04-22

    申请号：US12654596

    申请日：2009-12-23

    申请人： Antoine De Saizieu ,  Ann Fowler ,  Regina Goralczyk ,  Claus Kilpert ,  Goede Schueler ,  Christof Wehrli

    发明人： Antoine De Saizieu ,  Ann Fowler ,  Regina Goralczyk ,  Claus Kilpert ,  Goede Schueler ,  Christof Wehrli

    IPC分类号： A61K31/335 ,  A61K31/215 ,  A61K31/19 ,  A61K31/122 ,  A61K31/05

    CPC分类号： A61K31/192 ,  A23K20/105 ,  A23K50/40 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/085 ,  A61K31/122 ,  A61K31/19 ,  A61K31/365 ,  A23V2200/322 ,  A23V2250/21

    摘要： The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein R1 is hydrogen or C1-6-alkyl; R2 is hydroxy, C3-5-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C1-6-alkyl; R3 and R4 independently from each other are hydrogen, hydroxy, hydroxymethyl, C1-5-acyloxy or C1-6-alkoxy; R5 is C1-6-alkyl, hydroxymethyl carboxy or methoxycarbonyl; R9 is hydrogen, hydroxymethyl, methoxy, oxo or C1-5-acyloxy; R10 is hydrogen, or R5 and R9 taken together are —CH2—O— or —O—CH2—; or R5 and R10 taken together are —CO—O—, —O—CO—, —CH2—O— or —O—CH2—; R6 is hydrogen, or R5 and R6 together form a bond; R7 and R8 independently from each other are C1-6-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C1-6-alkoxycarbonyl with the proviso that at least one of R7 and R8 is C1-6-alkyl; R11 and R12 are both hydrogen or R11 and R12 together are oxo, with the further proviso for formula (I) that if R2 is hydroxy R1 is C1-6-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.

    摘要翻译： 本发明涉及式（I）和（II）的三环二萜及其衍生物，其中R 1是氢或C 1-6 - 烷基; R2是羟基，C3-5-酰氧基，羟甲基，1,3-二羟基丙基或C1-6烷基; R 3和R 4彼此独立地是氢，羟基，羟甲基，C 1-5 - 酰氧基或C 1-6 - 烷氧基; R5是C1-6烷基，羟甲基羧基或甲氧基羰基; R9是氢，羟甲基，甲氧基，氧代或C1-5-酰氧基; R 10是氢，或者R 5和R 9一起是-CH 2 -O-或-O-CH 2 - ; 或R 5和R 10一起是-CO-O-，-O-CO-，-CH2-O-或-O-CH2-; R6是氢，或R5和R6一起形成键; R 7和R 8彼此独立地是C 1-6 - 烷基，羧基，x-羟基-C 1-6 - 烷基（x是1至6的整数）或C 1-6 - 烷氧基羰基，条件是R 7 并且R 8是C 1-6 - 烷基; R 11和R 12都是氢或R 11和R 12一起是氧代，进一步的条件是式（I），如果R 2是羟基，则R 1是C 1-6 - 烷基，用作治疗与神经传递受损有关的病症的药物 ，以及饮食和药物组合物及其用途。

    Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivates and their uses
    5.
    发明授权
    Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivates and their uses 失效
    含三环二萜及其衍生物及其用途的膳食和药物组合物

    公开(公告)号：US08552055B2

    公开(公告)日：2013-10-08

    申请号：US12654596

    申请日：2009-12-23

    申请人： Antoine De Saizieu ,  Ann Fowler ,  Regina Goralczyk ,  Claus Kilpert ,  Goede Schueler ,  Christof Wehrli

    发明人： Antoine De Saizieu ,  Ann Fowler ,  Regina Goralczyk ,  Claus Kilpert ,  Goede Schueler ,  Christof Wehrli

    IPC分类号： A01N43/02 ,  A01N37/10 ,  A61K31/235 ,  A61K31/19

    CPC分类号： A61K31/192 ,  A23K20/105 ,  A23K50/40 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/085 ,  A61K31/122 ,  A61K31/19 ,  A61K31/365 ,  A23V2200/322 ,  A23V2250/21

    摘要： The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein R1 is hydrogen or C1-6-alkyl; R2 is hydroxy, C3-5-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C1-6-alkyl; R3 and R4 independently from each other are hydrogen, hydroxy, hydroxymethyl, C1-5-acyloxy or C1-6-alkoxy; R5 is C1-6-alkyl, hydroxymethyl carboxy or methoxycarbonyl; R9 is hydrogen, hydroxymethyl, methoxy, oxo or C1-5-acyloxy; R10 is hydrogen, or R5 and R9 taken together are —CH2—O— or —O—CH2—; or R5 and R10 taken together are —CO—O—, —O—CO—, —CH2—O— or —O—CH2—; R6 is hydrogen, or R5 and R6 together form a bond; R7 and R8 independently from each other are C1-6-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C1-6-alkoxycarbonyl with the proviso that at least one of R7 and R8 is C1-6-alkyl; R11 and R12 are both hydrogen or R11 and R12 together are oxo, with the further proviso for formula (I) that if R2 is hydroxy R1 is C1-6-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.

    摘要翻译： 本发明涉及式（I）和（II）的三环二萜及其衍生物，其中R 1是氢或C 1-6 - 烷基; R2是羟基，C3-5-酰氧基，羟甲基，1,3-二羟基丙基或C1-6烷基; R 3和R 4彼此独立地是氢，羟基，羟甲基，C 1-5 - 酰氧基或C 1-6 - 烷氧基; R5是C1-6烷基，羟甲基羧基或甲氧基羰基; R9是氢，羟甲基，甲氧基，氧代或C1-5-酰氧基; R 10是氢，或者R 5和R 9一起是-CH 2 -O-或-O-CH 2 - ; 或R 5和R 10一起是-CO-O-，-O-CO-，-CH2-O-或-O-CH2-; R6是氢，或R5和R6一起形成键; R 7和R 8彼此独立地是C 1-6 - 烷基，羧基，x-羟基-C 1-6 - 烷基（x是1至6的整数）或C 1-6 - 烷氧基羰基，条件是R 7 并且R 8是C 1-6 - 烷基; R 11和R 12都是氢或R 11和R 12一起是氧代，进一步的条件是式（I），如果R 2是羟基，则R 1是C 1-6 - 烷基，用作治疗与神经传递受损有关的病症的药物 ，以及饮食和药物组合物及其用途。

    DIETARY AND PHARMACEUTICAL COMPOSITIONS CONTAINING TRICYCLIC DITERPENES AND THEIR DERIVATIVES AND THEIR USES
    7.
    发明申请
    DIETARY AND PHARMACEUTICAL COMPOSITIONS CONTAINING TRICYCLIC DITERPENES AND THEIR DERIVATIVES AND THEIR USES 审中-公开
    含有三聚磷酸酯及其衍生物及其用途的膳食和药物组合物

    公开(公告)号：US20090099251A1

    公开(公告)日：2009-04-16

    申请号：US12297416

    申请日：2007-11-22

    申请人： Antoine De Saizieu ,  Ann Fowler ,  Regina Goralczyk ,  Claus Kilpert ,  Goede Schueler ,  Christof Wehrli

    发明人： Antoine De Saizieu ,  Ann Fowler ,  Regina Goralczyk ,  Claus Kilpert ,  Goede Schueler ,  Christof Wehrli

    IPC分类号： A61K31/335 ,  C07C61/22 ,  A61K31/19 ,  C07C39/12 ,  A61K31/05 ,  A61K31/122 ,  A61P25/00 ,  C07C49/543 ,  C07C69/74 ,  A61K31/215 ,  C07D315/00

    CPC分类号： A61K31/192 ,  A23K20/105 ,  A23K50/40 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/085 ,  A61K31/122 ,  A61K31/19 ,  A61K31/365 ,  A23V2200/322 ,  A23V2250/21

    摘要： The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein R1 is hydrogen or C1-6-alkyl; R2 is hydroxy, C3-5-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C1-6-alkyl; R3 and R4 independently from each other are hydrogen, hydroxy, hydroxymethyl, C1-5-acyloxy or C1-6-alkoxy; R5 is C1-6-alkyl, hydroxymethyl carboxy or methoxycarbonyl; R9 is hydrogen, hydroxymethyl, methoxy, oxo or C1-5-acyloxy; R10 is hydrogen, or R5 and R9 taken together are —CH2—O— or —O—CH2—; or R5 and R10 taken together are —CO—O—, —O—CO—, —CH2—O— or —O—CH2—; R6 is hydrogen, or R5 and R6 together form a bond; R7 and R8 independently from each other are C1-6-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C1-6-alkoxycarbonyl with the proviso that at least one of R7 and R8 is C1-6-alkyl; R11 and R12 are both hydrogen or R11 and R12 together are oxo, with the further proviso for formula (I) that if R2 is hydroxy R1 is C1-6-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.

    摘要翻译： 本发明涉及式（I）和（II）的三环二萜及其衍生物，其中R 1是氢或C 1-6 - 烷基; R2是羟基，C3-5-酰氧基，羟甲基，1,3-二羟基丙基或C1-6烷基; R 3和R 4彼此独立地是氢，羟基，羟甲基，C 1-5 - 酰氧基或C 1-6 - 烷氧基; R5是C1-6烷基，羟甲基羧基或甲氧基羰基; R9是氢，羟甲基，甲氧基，氧代或C1-5-酰氧基; R 10是氢，或者R 5和R 9一起是-CH 2 -O-或-O-CH 2 - ; 或R 5和R 10一起是-CO-O-，-O-CO-，-CH2-O-或-O-CH2-; R6是氢，或R5和R6一起形成键; R 7和R 8彼此独立地是C 1-6 - 烷基，羧基，x-羟基-C 1-6 - 烷基（x是1至6的整数）或C 1-6 - 烷氧基羰基，条件是R 7 并且R 8是C 1-6 - 烷基; R 11和R 12都是氢或R 11和R 12一起是氧代，进一步的条件是式（I），如果R 2是羟基，则R 1是C 1-6 - 烷基，用作治疗与神经传递受损有关的病症的药物 ，以及饮食和药物组合物及其用途。

    Agents for preventing and treating disorders connected to impaired neurotransmission
    8.
    发明授权
    Agents for preventing and treating disorders connected to impaired neurotransmission 失效
    用于预防和治疗与神经传递受损有关的障碍的药剂

    公开(公告)号：US08044094B2

    公开(公告)日：2011-10-25

    申请号：US11665072

    申请日：2005-10-21

    申请人： Antoine De Saizieu ,  Ann Fowler ,  Regina Goralczyk ,  Goede Schueler ,  Bernd Mussler

    发明人： Antoine De Saizieu ,  Ann Fowler ,  Regina Goralczyk ,  Goede Schueler ,  Bernd Mussler

    IPC分类号： A61K31/37

    CPC分类号： A61K31/37 ,  A23L2/39 ,  A23L7/126 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/21 ,  A23V2200/322

    摘要： The present invention refers to coumarin ethers of the formula (I), wherein R1 is H, OH or (E)-3-methyl-but-2-enyl, R2 is selected from the group consisting of methyl, 3-(4,5-dihydro-5,5-dimethyl-4-furanon-2-yl)-2-(E/Z)-butenyl, (E/Z)-3,7-dimethylocta-2,6-dienyl, 7-hydroxy-3,7-dimethyl-2-octen-6-on-yl and (E/Z,E/Z)-11-acetyl-oxy-3,7,11,11-tetramethyl-undeca-2,7-dien-10-on-yl, R3 is H, R1 and R2O together for the group —O—C(C(═CH2)CH3)H—CH2—O— or the group —C(H)═C(H)—C(CH3)2—O— or R2O and R3 together form the group —O—C(H)(C(CH3)2(H)—O—C(O)CH3)—CH2—, preferably to obliquin, for use as medicaments, especially for the treatment and/or prevention of disorders connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and plant extracts containing such coumarin ethers and their uses.

    摘要翻译： 本发明涉及式（I）的香豆素醚，其中R1是H，OH或（E）-3-甲基 - 丁-2-烯基，R2选自甲基，3-（4， 2-（E / Z） - 丁烯基，（E / Z）-3,7-二甲基辛-2,6-二烯基，7-羟基 -3,7-二甲基-2-辛烯-6-酮和（E / Z，E / Z）-11-乙酰氧基-3,7,11,11-四甲基 - 十一碳-2,7-二烯 （C（= CH 2）CH 3）H-CH 2 -O-或基团-C（H）= C（H） - 基，R 3为H，R 1和R 2 O为-O C（CH 3）2 -O-或R 2 O和R 3一起形成-O-C（H）（C（CH 3）2（H）-O-C（O）CH 3）-CH 2基团，优选为阴性， 用作药物，特别是用于治疗和/或预防与神经传递受损有关的障碍，以及含有这种香豆素醚的饮食和药物组合物和植物提取物及其用途。

    3,5-DIHYDROXY-2,4-CYCLOHEXADIENONES AND THEIR DERIVATIVES, DIETARY COMPOSITIONS AND FORTIFIED FOOD CONTAINING THEM AND THEIR USES
    9.
    发明申请
    3,5-DIHYDROXY-2,4-CYCLOHEXADIENONES AND THEIR DERIVATIVES, DIETARY COMPOSITIONS AND FORTIFIED FOOD CONTAINING THEM AND THEIR USES 失效
    3,5-DIHYDROXY-2,4-CYCLOHEXADENENESES及其衍生物，膳食组合物和含有它们的食品及其用途

    公开(公告)号：US20090270513A1

    公开(公告)日：2009-10-29

    申请号：US12301339

    申请日：2007-05-24

    申请人： Regina Goralczyk ,  Ann Fowler ,  Goede Schueler ,  Antoine De Saizieu

    发明人： Regina Goralczyk ,  Ann Fowler ,  Goede Schueler ,  Antoine De Saizieu

    IPC分类号： A61K31/122 ,  C07C49/657 ,  A61P25/22

    CPC分类号： A61K31/122 ,  A23K20/10 ,  A23K50/10 ,  A23K50/30 ,  A23K50/42 ,  A23K50/48 ,  A23K50/75 ,  A23L33/105

    摘要： The present invention refers especially to 3,5-dihydroxy-2,4-cyclohexadienones of the general formula (I) wherein R1 and R2 are independently from each other C1-6-alkyl, C2-6-alkenyl or x-oxo-Cx-alkyl with x being an integer from 1 to 6, preferably R1 and R2 are independently from each other C2-6-alkenyl or y-oxo-Cy-alkyl with y being an integer from 2 to 5, and wherein R3 and R4 are independently from each other hydroxy, C1-6-alkyl, C2-6-alkenyl or x-oxo-Cx- alkyl with x being an integer from 1 to 6, preferably R3 and R4 are independently from each other hydroxy or y-oxo-Cy-alkyl with y being an integer from 2 to 5, for use as mood balancing agents and stress relievers, as well as to dietary compositions and fortified food/feed/beverages containing such 3,5-dihydroxy-2,4-cyclohexadienones of the general formula (I), and their uses.

    摘要翻译： 本发明特别涉及通式（I）的3,5-二羟基-2,4-环己二烯酮，其中R 1和R 2彼此独立地为C 1-6 - 烷基，C 2-6 - 烯基或x-氧代-C - 烷基，其中x为1至6的整数，优选R 1和R 2彼此独立地为C 2-6 - 烯基或γ-氧代-Cy-烷基，其中y为2至5的整数，并且其中R 3和R 4为 彼此独立地为羟基，C 1-6 - 烷基，C 2-6 - 烯基或x-氧代-C 1-6 - 烷基，x为1至6的整数，优选为R 3和R 4彼此独立地为羟基或γ-氧代 - γ-烷基，其中y为2至5的整数，用作情绪平衡剂和应激缓解剂，以及含有这样的3,5-二羟基-2,4-环己二烯酮的饮食组合物和强化食品/饲料/饮料 通式（I）及其用途。

    Novel Agents for Preventing and Treating Disorders Connected to Impaired Neurotransmission
    10.
    发明申请
    Novel Agents for Preventing and Treating Disorders Connected to Impaired Neurotransmission 失效
    用于预防和治疗与受损神经传递相关的疾病的新型药剂

    公开(公告)号：US20070293563A1

    公开(公告)日：2007-12-20

    申请号：US11665072

    申请日：2005-10-21

    申请人： Antoine De Saizieu ,  Ann Fowler ,  Regina Goralczyk ,  Goede Schueler ,  Bernd Mussler

    发明人： Antoine De Saizieu ,  Ann Fowler ,  Regina Goralczyk ,  Goede Schueler ,  Bernd Mussler

    IPC分类号： A61K31/37 ,  A23L1/30 ,  A61P25/00 ,  A61P25/24 ,  C07D311/02

    CPC分类号： A61K31/37 ,  A23L2/39 ,  A23L7/126 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/21 ,  A23V2200/322

    摘要： The present invention refers to coumarin ethers of the formula (I), wherein R1 is H, OH or (E)-3-methyl-but-2-enyl, R2 is selected from the group consisting of methyl, 3-(4,5-dihydro-5,5-dimethyl-4-furanon-2-yl)-2-(E/Z)-butenyl, (E/Z)-3,7-dimethylocta-2,6-dienyl, 7-hydroxy-3,7-dimethyl-2-octen-6-on-yl and (E/Z, E/Z)-1-acetyl-oxy-3,7,11,11-tetramethyl-undeca-2,7-dien-10-on-yl, R3 is H, R1 and R2O together for the group —O—C(C(═CH2)CH3)H—CH2—O— or the group —C(H)═C(H)—C(CH3)2—O— or R2O and R3 together form the group —O—C(H)(C(CH3)2(H)—O—C(O)CH3)—CH2—, preferably to obliquin, for use as medicaments, especially for the treatment and/or prevention of disorders connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and plant extracts containing such coumarin ethers and their uses.

    摘要翻译： 本发明涉及式（I）的香豆素醚，其中R 1是H，OH或（E）-3-甲基 - 丁-2-烯基，R 2， 选自甲基，3-（4,5-二氢-5,5-二甲基-4-呋喃酮-2-基）-2-（E / Z） - 丁烯基，（E / Z） -3,7-二甲基辛-2,6-二烯基，7-羟基-3,7-二甲基-2-辛烯-6-酮和（E / Z，E / Z）-1-乙酰氧基-3 ，7,11,11-四甲基 - 十一碳烯-2,7-二烯-10-基，R 3是H，R 1和R 2 基团-OC（C（-CH 2 CH 2）CH 3）H-CH 2 -O-或-O- 基团-C（H）-C（H）-C（CH 3 3）2 -O-或R 2 O， SUP> 3一起形成基团-OC（H）（C（CH 3）2）（H）-OC（O）CH 3 用作药物，特别是用于治疗和/或预防与受损的神经传递相关的障碍，以及膳食和药物组合物和 含有此类香豆素醚的植物提取物及其用途 。