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    3,5-dihydroxy-2,4-cyclohexadienones and their derivatives, dietary compositions and fortified food containing them and their uses
    3.
    发明授权
    3,5-dihydroxy-2,4-cyclohexadienones and their derivatives, dietary compositions and fortified food containing them and their uses 失效
    3,5-二羟基-2,4-环己二烯酮及其衍生物，膳食组合物和含有它们的强化食品及其用途

    公开(公告)号：US07919531B2

    公开(公告)日：2011-04-05

    申请号：US12301339

    申请日：2007-05-24

    申请人： Regina Goralczyk ,  Ann Fowler ,  Goede Schuler ,  Antoine De Saizieu

    发明人： Regina Goralczyk ,  Ann Fowler ,  Goede Schuler ,  Antoine De Saizieu

    IPC分类号： A61K31/122

    CPC分类号： A61K31/122 ,  A23K20/10 ,  A23K50/10 ,  A23K50/30 ,  A23K50/42 ,  A23K50/48 ,  A23K50/75 ,  A23L33/105

    摘要： The present invention refers especially to 3,5-dihydroxy-2,4-cyclohexadienones of the general formula (I) wherein R1 and R2 are independently from each other C1-6-alkyl, C2-6-alkenyl or x-oxo-Cx-alkyl with x being an integer from 1 to 6, preferably R1 and R2 are independently from each other C2-6-alkenyl or y-oxo-Cy-alkyl with y being an integer from 2 to 5, and wherein R3 and R4 are independently from each other hydroxy, C1-6-alkyl, C2-6-alkenyl or x-oxo-Cx-alkyl with x being an integer from 1 to 6, preferably R3 and R4 are independently from each other hydroxy or y-oxo-Cy-alkyl with y being an integer from 2 to 5, for use as mood balancing agents and stress relievers, as well as to dietary compositions and fortified food/feed/beverages containing such 3,5-dihydroxy-2,4-cyclohexadienones of the general formula (I), and their uses.

    摘要翻译： 本发明特别涉及通式（I）的3,5-二羟基-2,4-环己二烯酮，其中R 1和R 2彼此独立地为C 1-6 - 烷基，C 2-6 - 烯基或x-氧代-C - 烷基，其中x为1至6的整数，优选R 1和R 2彼此独立地为C 2-6 - 烯基或γ-氧代-Cy-烷基，其中y为2至5的整数，并且其中R 3和R 4为 彼此独立地为羟基，C 1-6 - 烷基，C 2-6 - 烯基或x-氧代-C 1-6 - 烷基，x为1至6的整数，优选为R 3和R 4彼此独立地为羟基或γ-氧代 - γ-烷基，其中y为2至5的整数，用作情绪平衡剂和应激缓解剂，以及含有这样的3,5-二羟基-2,4-环己二烯酮的饮食组合物和强化食品/饲料/饮料 通式（I）及其用途。

    Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivates and their uses
    5.
    发明申请
    Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivates and their uses 失效
    含有三环二萜及其衍生物及其用途的膳食和药物组合物

    公开(公告)号：US20100099753A1

    公开(公告)日：2010-04-22

    申请号：US12654596

    申请日：2009-12-23

    申请人： Antoine De Saizieu ,  Ann Fowler ,  Regina Goralczyk ,  Claus Kilpert ,  Goede Schueler ,  Christof Wehrli

    发明人： Antoine De Saizieu ,  Ann Fowler ,  Regina Goralczyk ,  Claus Kilpert ,  Goede Schueler ,  Christof Wehrli

    IPC分类号： A61K31/335 ,  A61K31/215 ,  A61K31/19 ,  A61K31/122 ,  A61K31/05

    CPC分类号： A61K31/192 ,  A23K20/105 ,  A23K50/40 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/085 ,  A61K31/122 ,  A61K31/19 ,  A61K31/365 ,  A23V2200/322 ,  A23V2250/21

    摘要： The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein R1 is hydrogen or C1-6-alkyl; R2 is hydroxy, C3-5-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C1-6-alkyl; R3 and R4 independently from each other are hydrogen, hydroxy, hydroxymethyl, C1-5-acyloxy or C1-6-alkoxy; R5 is C1-6-alkyl, hydroxymethyl carboxy or methoxycarbonyl; R9 is hydrogen, hydroxymethyl, methoxy, oxo or C1-5-acyloxy; R10 is hydrogen, or R5 and R9 taken together are —CH2—O— or —O—CH2—; or R5 and R10 taken together are —CO—O—, —O—CO—, —CH2—O— or —O—CH2—; R6 is hydrogen, or R5 and R6 together form a bond; R7 and R8 independently from each other are C1-6-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C1-6-alkoxycarbonyl with the proviso that at least one of R7 and R8 is C1-6-alkyl; R11 and R12 are both hydrogen or R11 and R12 together are oxo, with the further proviso for formula (I) that if R2 is hydroxy R1 is C1-6-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.

    摘要翻译： 本发明涉及式（I）和（II）的三环二萜及其衍生物，其中R 1是氢或C 1-6 - 烷基; R2是羟基，C3-5-酰氧基，羟甲基，1,3-二羟基丙基或C1-6烷基; R 3和R 4彼此独立地是氢，羟基，羟甲基，C 1-5 - 酰氧基或C 1-6 - 烷氧基; R5是C1-6烷基，羟甲基羧基或甲氧基羰基; R9是氢，羟甲基，甲氧基，氧代或C1-5-酰氧基; R 10是氢，或者R 5和R 9一起是-CH 2 -O-或-O-CH 2 - ; 或R 5和R 10一起是-CO-O-，-O-CO-，-CH2-O-或-O-CH2-; R6是氢，或R5和R6一起形成键; R 7和R 8彼此独立地是C 1-6 - 烷基，羧基，x-羟基-C 1-6 - 烷基（x是1至6的整数）或C 1-6 - 烷氧基羰基，条件是R 7 并且R 8是C 1-6 - 烷基; R 11和R 12都是氢或R 11和R 12一起是氧代，进一步的条件是式（I），如果R 2是羟基，则R 1是C 1-6 - 烷基，用作治疗与神经传递受损有关的病症的药物 ，以及饮食和药物组合物及其用途。

    NOVEL ACTIVES AGAINST PROSTATE CARCINOMA
    6.
    发明申请
    NOVEL ACTIVES AGAINST PROSTATE CARCINOMA 审中-公开
    对前瞻性癌症的新兴活动

    公开(公告)号：US20090326056A1

    公开(公告)日：2009-12-31

    申请号：US12299825

    申请日：2007-05-15

    申请人： Regina Goralczyk ,  Ulrich Siler ,  Karin Wertz

    发明人： Regina Goralczyk ,  Ulrich Siler ,  Karin Wertz

    IPC分类号： A61K31/352

    CPC分类号： A61K31/01 ,  A61K31/353 ,  A61K31/355 ,  A61K2300/00

    摘要： The present invention relates to the use of a composition comprising lycopene and genistein in the prevention and coadjuvant treatment of prostate carcinoma. The present invention is also directed to the use of a composition comprising lycopene and epigallocatechin gallate in the prevention and coadjuvant treatment of prostate carcinoma. More specifically, the present invention relates to the use of one of these compositions in the primary prevention (i.e., the prophylactic supplementation of healthy subjects) of the onset of prostate carcinoma, in the coadjuvant treatment (i.e. the supplementation accompanying a running therapy of prostate carcinoma) and in the secondary prevention (i.e., the supplementation after a successful therapy for the prevention of relapse) of prostate carcinoma. Furthermore, the present invention is also directed to the reduction/decrease of the PSA plasma level in the blood of subjects to whom either a composition comprising lycopene and genistein or to whom either a composition comprising lycopene and epigallocatechin gallate are administered. Further compounds that may preferably also be present in the composition of the present invention are vitamin E, resveratrol and polyunsaturated fatty acid (derivative)s.

    摘要翻译： 本发明涉及包含番茄红素和染料木素的组合物在预防和辅助治疗前列腺癌中的用途。 本发明还涉及包含番茄红素和表没食子儿茶素没食子酸酯的组合物在预防和辅助治疗前列腺癌中的用途。 更具体地说，本发明涉及这些组合物中的一种在辅助治疗中的一级预防（即健康受试者的预防性补充）前列腺癌发作的用途（即伴随前列腺的运行治疗的补充） 癌症）和前列腺癌的二次预防（即成功治疗预防复发后的补充）。 此外，本发明还涉及给予包含番茄红素和染料木素的组合物或包含番茄红素和表没食子儿茶素没食子酸酯的组合物的受试者的血液中PSA血浆水平的降低/降低。 还可以存在于本发明组合物中的其它化合物是维生素E，白藜芦醇和多不饱和脂肪酸（衍生物）。

    Novel use of lycopene
    9.
    发明申请
    Novel use of lycopene 审中-公开
    小说使用番茄红素

    公开(公告)号：US20060069151A1

    公开(公告)日：2006-03-30

    申请号：US10537452

    申请日：2003-12-04

    申请人： Luca Barella ,  Regina Goralczyk ,  Ulrich Siler ,  Karin Wertz

    发明人： Luca Barella ,  Regina Goralczyk ,  Ulrich Siler ,  Karin Wertz

    IPC分类号： A61K31/375 ,  A61K31/355 ,  A61K31/353 ,  A61K31/015

    CPC分类号： A61K31/355 ,  A61K31/01 ,  A61K31/375 ,  A61K2300/00

    摘要： Lycopene can be used in the primary prevention and incidence risk reduction of non-cancerous symptoms and/or pathologies (i.e., the prophylactic supplementation of the healthy subjects), in the treatment or the coadjuvant treatment of non-can-cerous symptoms and/or pathologies (i.e. the supplementation as therapy or accompanying a running therapy) and in the secondary prevention of non-cancerous symptoms and/or pahtologies (i.e., the supplementation after a successful therapy for the prevention of the relapse), which are associated with, favored by or caused by androgen signalling or which are sensitive to a reduction of androgen signalling.

    摘要翻译： 番茄红素可用于非癌症症状和/或非癌症症状的治疗或辅助治疗中非癌症症状和/或病态（即健康受试者的预防性补充）的一级预防和发病风险降低 病理学（即作为治疗或伴随运行疗法的补充剂）和二次预防非癌症症状和/或睑炎（即，成功治疗以后用于预防复发的补充剂）与青睐相关 由雄激素信号传导或由其引起，或对雄激素信号传导的降低敏感。

    Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivates and their uses
    10.
    发明授权
    Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivates and their uses 失效
    含三环二萜及其衍生物及其用途的膳食和药物组合物

    公开(公告)号：US08552055B2

    公开(公告)日：2013-10-08

    申请号：US12654596

    申请日：2009-12-23

    申请人： Antoine De Saizieu ,  Ann Fowler ,  Regina Goralczyk ,  Claus Kilpert ,  Goede Schueler ,  Christof Wehrli

    发明人： Antoine De Saizieu ,  Ann Fowler ,  Regina Goralczyk ,  Claus Kilpert ,  Goede Schueler ,  Christof Wehrli

    IPC分类号： A01N43/02 ,  A01N37/10 ,  A61K31/235 ,  A61K31/19

    CPC分类号： A61K31/192 ,  A23K20/105 ,  A23K50/40 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/085 ,  A61K31/122 ,  A61K31/19 ,  A61K31/365 ,  A23V2200/322 ,  A23V2250/21

    摘要： The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein R1 is hydrogen or C1-6-alkyl; R2 is hydroxy, C3-5-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C1-6-alkyl; R3 and R4 independently from each other are hydrogen, hydroxy, hydroxymethyl, C1-5-acyloxy or C1-6-alkoxy; R5 is C1-6-alkyl, hydroxymethyl carboxy or methoxycarbonyl; R9 is hydrogen, hydroxymethyl, methoxy, oxo or C1-5-acyloxy; R10 is hydrogen, or R5 and R9 taken together are —CH2—O— or —O—CH2—; or R5 and R10 taken together are —CO—O—, —O—CO—, —CH2—O— or —O—CH2—; R6 is hydrogen, or R5 and R6 together form a bond; R7 and R8 independently from each other are C1-6-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C1-6-alkoxycarbonyl with the proviso that at least one of R7 and R8 is C1-6-alkyl; R11 and R12 are both hydrogen or R11 and R12 together are oxo, with the further proviso for formula (I) that if R2 is hydroxy R1 is C1-6-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.

    摘要翻译： 本发明涉及式（I）和（II）的三环二萜及其衍生物，其中R 1是氢或C 1-6 - 烷基; R2是羟基，C3-5-酰氧基，羟甲基，1,3-二羟基丙基或C1-6烷基; R 3和R 4彼此独立地是氢，羟基，羟甲基，C 1-5 - 酰氧基或C 1-6 - 烷氧基; R5是C1-6烷基，羟甲基羧基或甲氧基羰基; R9是氢，羟甲基，甲氧基，氧代或C1-5-酰氧基; R 10是氢，或者R 5和R 9一起是-CH 2 -O-或-O-CH 2 - ; 或R 5和R 10一起是-CO-O-，-O-CO-，-CH2-O-或-O-CH2-; R6是氢，或R5和R6一起形成键; R 7和R 8彼此独立地是C 1-6 - 烷基，羧基，x-羟基-C 1-6 - 烷基（x是1至6的整数）或C 1-6 - 烷氧基羰基，条件是R 7 并且R 8是C 1-6 - 烷基; R 11和R 12都是氢或R 11和R 12一起是氧代，进一步的条件是式（I），如果R 2是羟基，则R 1是C 1-6 - 烷基，用作治疗与神经传递受损有关的病症的药物 ，以及饮食和药物组合物及其用途。