公开(公告)号：US06696599B2

公开(公告)日：2004-02-24

申请号：US10437058

申请日：2003-05-14

申请人： Antonia Jekkel ,  Attila Konya ,  Istvan Barta ,  Eva Ilkoy ,  Gyorgy Somogyi ,  Gabor Ambrus ,  Gyula Horvath ,  Karoly Albrecht ,  Istvan Szabo ,  Julianna Mozes Nee Suto ,  Janso Salat ,  Attila Andor ,  Laszlo Birincsik ,  Sandor Boros ,  Ildiko Lang ,  Margit Bidlo Nee Igloy

发明人： Antonia Jekkel ,  Attila Konya ,  Istvan Barta ,  Eva Ilkoy ,  Gyorgy Somogyi ,  Gabor Ambrus ,  Gyula Horvath ,  Karoly Albrecht ,  Istvan Szabo ,  Julianna Mozes Nee Suto ,  Janso Salat ,  Attila Andor ,  Laszlo Birincsik ,  Sandor Boros ,  Ildiko Lang ,  Margit Bidlo Nee Igloy

IPC分类号： C07C6702

CPC分类号： C12R1/645 ,  C12P7/62

摘要： The present invention relates to a new microbial process for the preparation of the compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6&bgr;-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6&bgr;-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.

摘要翻译： 本发明涉及一种由通式（II）的化合物制备式（I）化合物的新的微生物方法，其中R代表碱金属或铵离子，通过浸没式培养能够提供6β 在需氧发酵中通过分解和纯化在生物转化过程中形成的式（I）的产物来氢化式（II）化合物。 该方法包括在含有可吸收的碳和氮源和矿物盐的营养培养基上培养能够将通式（II）的化合物6β-羟基化的高山被孢霉丝状菌种的菌株，并分离由发酵形成的产物 肉汤，然后分离式（I）化合物并纯化。 还公开了高山被孢霉的新型菌株。

公开(公告)号：US06682913B1

公开(公告)日：2004-01-27

申请号：US09497805

申请日：2000-02-03

申请人： Antonia Jekkel ,  Attila Konya ,  Istvan Barta ,  Eva Ilkoy ,  Gyorgy Somogyi ,  Gabor Ambrus ,  Gyula Horvath ,  Karoly Albrecht ,  Istvan Szabo ,  Julianna Mozes nee Suto ,  Janso Salat ,  Attila Andor ,  Laszlo Birincsik ,  Sandor Boros ,  Ildiko Lang ,  Margit Bidlo nee Igloy

发明人： Antonia Jekkel ,  Attila Konya ,  Istvan Barta ,  Eva Ilkoy ,  Gyorgy Somogyi ,  Gabor Ambrus ,  Gyula Horvath ,  Karoly Albrecht ,  Istvan Szabo ,  Julianna Mozes nee Suto ,  Janso Salat ,  Attila Andor ,  Laszlo Birincsik ,  Sandor Boros ,  Ildiko Lang ,  Margit Bidlo nee Igloy

IPC分类号： C12P762

CPC分类号： C12R1/645 ,  C12P7/62

摘要： The present invention relates to a new microbial process for the preparation of the compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6&bgr;-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6&bgr;-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.

公开(公告)号：US20060281155A1

公开(公告)日：2006-12-14

申请号：US11509662

申请日：2006-08-25

申请人： Antonia Jekkel ,  Attila Konya ,  Istvan Barta ,  Eva Ilkoy ,  Gyorgy Somogyi ,  Gabor Ambrus ,  Gyula Horvath ,  Karoly Albrecht ,  Istvan Szabo ,  Julianna Suto ,  Janos Salat ,  Attila Andor ,  Laszlo Birincsik ,  Sandor Boros ,  Ildiko Lang ,  Margit Nee Igloy

发明人： Antonia Jekkel ,  Attila Konya ,  Istvan Barta ,  Eva Ilkoy ,  Gyorgy Somogyi ,  Gabor Ambrus ,  Gyula Horvath ,  Karoly Albrecht ,  Istvan Szabo ,  Julianna Suto ,  Janos Salat ,  Attila Andor ,  Laszlo Birincsik ,  Sandor Boros ,  Ildiko Lang ,  Margit Nee Igloy

IPC分类号： C12P7/62

CPC分类号： C12R1/645 ,  C12P7/62

摘要： The present invention relates to a new microbial process for the preparation of the compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6β-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6β-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.