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    3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE
    8.
    发明申请
    3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE 有权
    3-异丙基-3,5-二氢-4-氧代-4H-吡啶并[4,5-B]吲哚-1-羧酰胺衍生物，其制备和治疗用途

    公开(公告)号：US20060241116A1

    公开(公告)日：2006-10-26

    申请号：US11427508

    申请日：2006-06-29

    申请人： Philippe BURNIER ,  Jacques FROISSANT ,  Benoit MARABOUT ,  Frank MARGUET ,  Frederic PUECH

    发明人： Philippe BURNIER ,  Jacques FROISSANT ,  Benoit MARABOUT ,  Frank MARGUET ,  Frederic PUECH

    IPC分类号： A61K31/503 ,  C07D487/02 ,  C07D209/42

    CPC分类号： C07D487/04 ,  C07D209/42

    摘要： A subject-matter of the invention is the compounds of general formula (I) in which X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 and R3 each represent, independently of one another, a hydrogen atom or a (C1-C4)alkyl group or else R2 and R3 form, with the nitrogen atom which carries them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type, it being possible for the heteroaromatic group to carry one or more halogen atoms and/or one or more (C1-C4)alkyl or (C1-C4)alkoxy groups; in the form of bases, of addition salts with acids, of solvates or of hydrates, the pharmaceutical compositions comprising them, processes for their preparation and synthetic intermediates.

    摘要翻译： 本发明的主题是通式（I）的化合物，其中X表示氢或卤素原子; R 1表示氢原子或（C 1 -C 4 -C 4）烷基; R 2和R 3各自独立地表示氢原子或（C 1 -C 4）烷基， 或者R 2和R 3形式，与携带它们的氮原子一起形成吡咯烷基，哌啶基，吗啉基或4-烷基哌嗪基; 并且Het表示吡啶基，1-氧化吡啶基，喹啉基，异喹啉基，嘧啶基，吡嗪基或哒嗪基的杂芳族基团，杂芳基可以携带一个或多个卤素原子和/或一个或多个（C 1 C 1 -C 4烷基或（C 1 -C 4 -C 4）烷氧基; 以碱的形式，与酸，溶剂合物或水合物的加成盐，包含它们的药物组合物，其制备方法和合成中间体。

    3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE
    9.
    发明申请
    3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE 审中-公开
    3-异丙基-3,5-二氢-4-氧代-4H-吡啶并[4,5-B]吲哚-1-羧酰胺衍生物，其制备和治疗用途

    公开(公告)号：US20090275576A1

    公开(公告)日：2009-11-05

    申请号：US12487902

    申请日：2009-06-19

    申请人： Philippe BURNIER ,  Jacques FROISSANT ,  Benoit MARABOUT ,  Frank MARGUET ,  Frederic PUECH

    发明人： Philippe BURNIER ,  Jacques FROISSANT ,  Benoit MARABOUT ,  Frank MARGUET ,  Frederic PUECH

    IPC分类号： A61K31/5377 ,  A61K31/5025 ,  A61P43/00

    CPC分类号： C07D487/04 ,  C07D209/42

    摘要： A subject-matter of the invention is the compounds of general formula (I) in which X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 and R3 each represent, independently of one another, a hydrogen atom or a (C1-C4)alkyl group or else R2 and R3 form, with the nitrogen atom which carries them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type, it being possible for the heteroaromatic group to carry one or more halogen atoms and/or one or more (C1-C4)alkyl or (C1-C4)alkoxy groups; in the form of bases, of addition salts with acids, of solvates or of hydrates, the pharmaceutical compositions comprising them, processes for their preparation and synthetic intermediates.

    摘要翻译： 本发明的主题是通式（I）的化合物，其中X表示氢或卤素原子; R1表示氢原子或（C1-C4）烷基; R2和R3各自独立地表示氢原子或（C1-C4）烷基，或者R2和R3与携带它们的氮原子一起形成吡咯烷基，哌啶基，吗啉基或4-烷基哌嗪基; 并且Het表示吡啶基，1-氧化吡啶基，喹啉基，异喹啉基，嘧啶基，吡嗪基或哒嗪基的杂芳族基团，杂芳基可以携带一个或多个卤素原子和/或一个或多个（C 1 -C 4）烷基 或（C 1 -C 4）烷氧基; 以碱的形式，与酸，溶剂合物或水合物的加成盐，包含它们的药物组合物，其制备方法和合成中间体。