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    INTRAVAGINAL DEVICES COMPRISING ANTICHOLINERGIC AGENTS, AND METHODS OF MAKING THEREOF
    1.
    发明申请
    INTRAVAGINAL DEVICES COMPRISING ANTICHOLINERGIC AGENTS, AND METHODS OF MAKING THEREOF 审中-公开
    包含抗胆碱剂的内装置及其制备方法

    公开(公告)号：US20120053534A1

    公开(公告)日：2012-03-01

    申请号：US13166309

    申请日：2011-06-22

    申请人： Anu Mahashabde ,  Jiaxiang Tsao

    发明人： Anu Mahashabde ,  Jiaxiang Tsao

    IPC分类号： A61M31/00 ,  B28B1/14

    CPC分类号： A61K9/0036

    摘要： The present invention is directed to an intravaginal device comprising: (a) an annular first matrix comprising a pocket and a pocket wall, wherein the pocket wall has a uniform thickness, and wherein the pocket wall encompasses the pocket; and (b) a second matrix comprising an anticholinergic agent, wherein the second matrix is located in the pocket.The present invention is also directed to a method of making an intravaginal device, the method comprising: (a) placing a first matrix into a mold, the mold being shaped so as to form an annular intravaginal device comprising a pocket and a pocket wall, wherein the pocket wall has a uniform thickness, and wherein the pocket wall encompasses the pocket; (b) curing the first matrix; (c) placing a second matrix comprising an anticholinergic agent in the pocket; and (d) curing the second matrix.

    摘要翻译： 本发明涉及一种阴道内装置，其包括：（a）环形第一矩阵，其包括口袋和口袋壁，其中所述口袋壁具有均匀的厚度，并且其中所述口袋壁包围所述口袋; 和（b）包含抗胆碱剂的第二基质，其中所述第二基质位于所述口袋中。 本发明还涉及一种制造阴道内装置的方法，所述方法包括：（a）将第一基质放置在模具中，所述模具成形为形成包括口袋和口袋壁的环形阴道内装置， 其中所述口袋壁具有均匀的厚度，并且其中所述口袋壁包围所述口袋; （b）固化第一基质; （c）将包含抗胆碱剂的第二基质置于口袋中; 和（d）固化第二基质。

    Devices for delivering agents to a vaginal tract
    2.
    发明申请
    Devices for delivering agents to a vaginal tract 审中-公开
    将药剂递送至阴道的装置

    公开(公告)号：US20060185678A1

    公开(公告)日：2006-08-24

    申请号：US11346560

    申请日：2006-02-03

    申请人： Lance Bronnenkant ,  Anu Mahashabde

    发明人： Lance Bronnenkant ,  Anu Mahashabde

    IPC分类号： A61F6/02

    CPC分类号： A61K9/0036 ,  A61F6/08 ,  A61K31/56 ,  A61K31/565

    摘要： The present invention is directed to devices for delivering agents to a vaginal tract, a device of the invention comprises a non-porous polymeric material substantially impermeable to an environment of the vaginal tract, the non-porous polymeric material forming a closed envelope which forms an internal space, wherein the closed envelope contains two or more distinct apertures.

    摘要翻译： 本发明涉及用于将药剂递送至阴道的装置，本发明的装置包括基本上不可渗透到阴道的环境的无孔聚合材料，所述无孔聚合物材料形成封闭的外壳，其形成 内部空间，其中封闭的信封包含两个或多个不同的孔。

    Method of systematically delivering SSRIs
    5.
    发明授权
    Method of systematically delivering SSRIs 失效
    系统地提供SSRIs的方法

    公开(公告)号：US07005138B2

    公开(公告)日：2006-02-28

    申请号：US10095558

    申请日：2002-03-12

    申请人： Anu Mahashabde ,  Martha Francine Kay ,  Brian Glazer ,  Junxiong Zhang

    发明人： Anu Mahashabde ,  Martha Francine Kay ,  Brian Glazer ,  Junxiong Zhang

    IPC分类号： A61F13/00 ,  A61F6/06 ,  A61F6/14

    CPC分类号： A61K9/02 ,  A61F2250/0067 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0036 ,  A61K9/12 ,  A61K9/122 ,  A61K9/7007

    摘要： Methods and compositions are disclosed for the intravaginal or rectal delivery of selected serotonin reuptake inhibitors (SSRIs) to the systemic circulation. Such methods and compositions are useful in the treatment of depression, migraine headaches, chronic pain, psychoactive substance abuse disorders, pre-menstrual dysphoric disorder (PMDD) and obsessive compulsive disorders. The compositions may be formulated for the immediate release or controlled release of SSRIs over an extended period of time. A preferred SSRI is fluoxetine.

    摘要翻译： 公开了将所选择的5-羟色胺再摄取抑制剂（SSRIs）的阴道内或直肠递送给系统循环的方法和组合物。 这些方法和组合物可用于治疗抑郁症，偏头痛，慢性疼痛，精神活性物质滥用障碍，月经前焦虑症（PMDD）和强迫症。 组合物可以配制成在长时间内立即释放或控释SSRIs。 优选的SSRI是氟西汀。

    Pharmaceutical compositions comprising prostanoid-receptor agonists and methods of making and using the same
    6.
    发明申请
    Pharmaceutical compositions comprising prostanoid-receptor agonists and methods of making and using the same 审中-公开
    包含前列腺素类受体激动剂的药物组合物及其制备和使用方法

    公开(公告)号：US20060286172A1

    公开(公告)日：2006-12-21

    申请号：US11446525

    申请日：2006-06-05

    申请人： Anu Mahashabde

    发明人： Anu Mahashabde

    IPC分类号： A61K9/14

    CPC分类号： A61K31/557 ,  A61K9/0036 ,  A61K47/10 ,  A61K47/26

    摘要： The present invention is related to pharmaceutical compositions comprising prostanoid-receptor agonists, intravaginal dosage forms comprising the same, and methods of making and using the same. The present invention is also related to a controlled release pharmaceutical gel for vaginal administration, the pharmaceutical gel comprising: (a) misoprostol; (b) a cellulose derivative; and (c) a polyol; wherein the gel is a substantially nonaqueous gel, and wherein the gel forms a hydrogel when placed in a vaginal tract.

    摘要翻译： 本发明涉及含有前列腺素类受体激动剂的药物组合物，包含其的阴道内剂型及其制备和使用方法。 本发明还涉及用于阴道给药的控释药物凝胶，所述药物凝胶包含：（a）米索前列醇; （b）纤维素衍生物; 和（c）多元醇; 其中所述凝胶是基本非水性凝胶，并且其中所述凝胶在置于阴道中时形成水凝胶。

    Device and method for treating urinary incontinence in females
    9.
    发明授权
    Device and method for treating urinary incontinence in females 有权
    用于治疗女性尿失禁的装置和方法

    公开(公告)号：US06436428B1

    公开(公告)日：2002-08-20

    申请号：US09531856

    申请日：2000-03-21

    申请人： Anu Mahashabde ,  Martha Francine Kay ,  Donald F. Koelmel

    发明人： Anu Mahashabde ,  Martha Francine Kay ,  Donald F. Koelmel

    IPC分类号： A61F614

    CPC分类号： A61K9/0036 ,  A61K31/216

    摘要： Provided herein is a novel and useful device and method for locally delivering and controllably releasing oxybutynin in the cervical region of a female. A device of the invention comprises a ring comprising trifluoropropylmethyl/dimethyl siloxane elastomer. A pharmaceutical composition comprising oxybutynin and an excipient is placed within a bore located in the ring, wherein the bore runs from the surface of the ring into the ring. The ring has a sufficient size such that it can be inserted into the vaginal canal of a female. A cap comprising is placed over the bore at the surface of the ring in order to contain the pharmaceutical composition within the bore. When the ring is inserted into the vaginal canal, the trifluoropropylmethyl/dimethyl siloxane elastomer controllably releases and locally delivers a therapeutically effective amount of oxybutynin to the detrusor muscle to treat the female's urinary incontinence.

    摘要翻译： 本文提供了一种用于局部递送和可控地释放女性颈部区域中的奥昔布宁的新颖且有用的装置和方法。 本发明的装置包括含有三氟丙基甲基/二甲基硅氧烷弹性体的环。 包含奥昔布宁和赋形剂的药物组合物放置在位于环中的孔中，其中孔从环的表面延伸到环中。 环具有足够的尺寸，使得其可以插入到女性的阴道管中。 将包括的盖子放置在环的表面上的孔上，以将药物组合物包含在孔内。 当环插入阴道内时，三氟丙基甲基/二甲基硅氧烷弹性体可控地释放并局部地将治疗有效量的奥昔布宁输送到逼尿肌以治疗女性的尿失禁。

    Apparatus and method for anesthetizing the cervical region of a female
    10.
    发明授权
    Apparatus and method for anesthetizing the cervical region of a female 有权
    用于麻醉女性颈部区域的装置和方法

    公开(公告)号：US06264973B1

    公开(公告)日：2001-07-24

    申请号：US09383887

    申请日：1999-08-26

    申请人： Anu Mahashabde ,  Martha Francine Kay ,  Louis J. Mestichelli ,  Ann Elizabeth Gooding ,  Suzanne Wilford Ruth

    发明人： Anu Mahashabde ,  Martha Francine Kay ,  Louis J. Mestichelli ,  Ann Elizabeth Gooding ,  Suzanne Wilford Ruth

    IPC分类号： A61F614

    CPC分类号： A61K9/0034 ,  A61K9/0036 ,  A61K31/167 ,  A61M31/00

    摘要： A novel and useful apparatus for delivering an anesthetic locally to the cervical region of a female is provided, wherein the apparatus comprises a ring having a surface and at least one depression on the surface. An anesthetic composition comprising an anesthetic agent and an excipient are placed within the at least one depression. The ring is comprised of a pharmaceutically acceptable inert material that is biocompatible. Furthermore, the ring is of sufficient size such that it can be inserted into the vaginal canal of a female. In the vaginal canal, the anesthetic agent is immediately released from the anesthetic composition and directly anesthetizes the cervical region.

    摘要翻译： 提供了一种用于将麻醉剂局部递送到女性的颈部区域的新颖且有用的装置，其中该装置包括具有表面和表面上的至少一个凹陷部的环。 将包含麻醉剂和赋形剂的麻醉剂组合物置于所述至少一个凹陷内。 该环由生物相容的药学上可接受的惰性物质组成。 此外，环具有足够的尺寸，使得其可以插入到女性的阴道管中。 在阴道内，麻醉剂立即从麻醉组合物中释放并直接麻醉宫颈区域。