公开(公告)号：US20240045191A1

公开(公告)日：2024-02-08

申请号：US18365853

申请日：2023-08-04

Applicant: Applied Materials, Inc.

Inventor： Ang Li ,  Joseph R. Johnson ,  Jean Marc Fan Chung Tsang Min Ching ,  Dan Xie ,  Stephen Hsiang ,  Yun-Ching Chang

IPC: G02B21/00 ,  G06T7/00 ,  G02B21/06

CPC classification number: G02B21/0076 ,  G06T7/0012 ,  G02B21/06

Abstract: An imaging system for capturing spatial images of biological tissue samples may include an imaging chamber configured to hold a biological tissue sample placed in the imaging system; a light source configured to illuminate the biological tissue sample to activate a plurality of fluorophores in the biological tissue sample; and a plurality of Time Delay and Integration (TDI) imagers configured to simultaneously scan the biological tissue sample, where the plurality of TDI imagers may be configured to separately receive light from different ones of the plurality of fluorophores.

公开(公告)号：US20240035967A1

公开(公告)日：2024-02-01

申请号：US18361586

申请日：2023-07-28

Applicant: Applied Materials, Inc.

Inventor： Joseph R. Johnson ,  Ang Li ,  Jean Marc Fan Chung Tsang Min Ching ,  Mehdi Vaez-Iravani

IPC: G01N21/47

CPC classification number: G01N21/4795

Abstract: An imaging system for capturing spatial-omic images of biological tissue samples may include an imaging chamber configured to secure a biological tissue sample placed in the imaging system; a Time Delay and Integration (TDI) imager comprising at least one scan line; a light source configured to illuminate an area on the biological tissue sample that is being captured by the TDI imager; and a controller configured to cause the TDI imager to scan the biological tissue sample using one or more TDI scans of the biological tissue sample.

公开(公告)号：US20230168495A1

公开(公告)日：2023-06-01

申请号：US18070643

申请日：2022-11-29

Applicant: Applied Materials, Inc.

Inventor： Ang Li ,  Danni Wang ,  Jean-Marc Fan Chung Tsang Min Ching

IPC: G02B27/00 ,  G02F1/1335

CPC classification number: G02B27/0062 ,  G02B27/0068 ,  G02F1/133526

Abstract: Methods and systems of correcting chromatic focal shift may include measuring a chromatic focal shift in focal points of a lens between first and second wavelengths of light passing through the lens. They also include detecting the first wavelength of light from a sample spaced at a first distance between the sample and the lens that corresponds to a first focal point for the first wavelength of light. They further include adjusting the sample and the lens to a second distance with a piezoelectric actuator. The second distance may be determined using the measurement of the chromatic focal shift between the first and second wavelengths of light passing through the lens. They additionally include detecting a second wavelength of light from the sample spaced at the second distance between the sample and the lens, where the second distance corresponds to a second focal point for the second wavelength of light.