摘要:
Compounds provided herein are novel substituted pyrazinones, pyridines and pyrimidines of Formula (I) and (II): Such compounds are particularly useful as CRF receptor ligands, and hence, in the treatment of various neurologically-related disorders such as affective disorder, anxiety and depression.
摘要:
Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
摘要:
A speaker (10) comprises an enclosure (8) defining an internal volume (11); and at least one sound generator (7), the sound generator (7) comprising one or more surfaces defining an air-path conduit (15) through which air operably passes in and out of the internal volume. The sound generator (7) further comprises a plurality of electrodes comprising at least one air-exposed electrode (1, 4) and at least one insulated electrode (2, 3). A voltage source (6) is configured to generate an electrical field between the at least one air-exposed electrode (1, 4) and the at least one insulated electrode (2, 3, 70) to operatively generate a plasma proximal (100) to the plurality of electrodes and within the air-path conduit (15).
摘要:
Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
摘要:
Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
摘要:
Corticotropin releasing factor (CRF) antagonists of Formula (I): and its use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
摘要:
Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
摘要:
The present invention provides 4-(bis(2-methoxyethyl)amino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-[1,5-α]-pyrazolo-1,3,5-triazine benzenesulfonate salt and a crystalline polymorph thereof. Further provided are pharmaceutical compositions containing the salt and methods of treating CRF-related disorders using said salt.
摘要:
Corticotropin releasing factor (CRF) antagonists of formula I or II: ##STR1## and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
摘要:
A speaker (10) comprises an enclosure (8) defining an internal volume (11); and at least one sound generator (7), the sound generator (7) comprising one or more surfaces defining an air-path conduit (15) through which air operably passes in and out of the internal volume. The sound generator (7) further comprises a plurality of electrodes comprising at least one air-exposed electrode (1, 4) and at least one insulated electrode (2, 3). A voltage source (6) is configured to generate an electrical field between the at least one air-exposed electrode (1, 4) and the at least one insulated electrode (2, 3, 70) to operatively generate a plasma proximal (100) to the plurality of electrodes and within the air-path conduit (15).