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    Imidazopyrimidinyl and imidazopyri dinyl derivatives
    6.
    发明授权
    Imidazopyrimidinyl and imidazopyri dinyl derivatives 有权
    咪唑并嘧啶基和咪唑并二烯基衍生物

    公开(公告)号：US07045529B2

    公开(公告)日：2006-05-16

    申请号：US09738666

    申请日：2000-12-15

    申请人： Richard G. Wilde ,  Rajagopal Bakthavatchalam ,  James P. Beck ,  Argyrios Arvanitis

    发明人： Richard G. Wilde ,  Rajagopal Bakthavatchalam ,  James P. Beck ,  Argyrios Arvanitis

    IPC分类号： A61K31/437 ,  C07D471/04

    CPC分类号： C07D471/04 ,  C07D473/00

    摘要： Provided herein are compounds of the formula (I): as well as stereoisomers and pharmaceutically acceptable salts thereof. Such compounds are, because of their ability to antagonize CRF, useful in the treatment of a variety of disorders characterized by execssive CRF expression. These include, for example: affective disorder, anxiety, depression, headache, irritable bowel syndrome, post-traumatic stress disorder, supranuclear palsy, immune suppression, Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, gastrointestinal diseases, anorexia nervosa or other feeding disorder, drug addiction, drug or alcohol withdrawal symptoms, inflammatory diseases, cardiovascular or heart-related diseases, fertility problems, human immunodeficiency virus infections, hemorrhagic stress, obesity, infertility, head and spinal cord traumas, epilepsy, stroke, ulcers, amyotrophic lateral sclerosis and hypoglycemia.

    摘要翻译： 本文提供了式（I）的化合物：及其立体异构体及其药学上可接受的盐。 因为这些化合物具有拮抗CRF的能力，其可用于治疗以执行性CRF表达为特征的多种疾病。 这些包括例如：情感障碍，焦虑症，抑郁症，头痛，肠易激综合征，创伤后应激障碍，核核性麻痹，免疫抑制，阿尔茨海默病，亨廷顿氏病，帕金森病，肌萎缩性侧索硬化，胃肠道疾病，神经性厌食症或 其他喂养障碍，药物成瘾，药物或酒精戒断症状，​​炎症性疾病，心血管疾病或心脏病，肥胖问题，人体免疫缺陷病毒感染，出血性压力，肥胖症，不育症，头部和脊髓创伤，癫痫，中风，溃疡， 肌萎缩性侧索硬化和低血糖。