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    NOVEL TARGETS OF ACINETOBACTER BAUMANNII
    4.
    发明申请
    NOVEL TARGETS OF ACINETOBACTER BAUMANNII 审中-公开

    公开(公告)号：US20200016258A1

    公开(公告)日：2020-01-16

    申请号：US16582413

    申请日：2019-09-25

    申请人： Aridis Pharmaceuticals Inc.

    发明人： Simon Urwyler ,  Markus Haake ,  Michael Rudolf

    IPC分类号： A61K39/104 ,  C07K14/21 ,  C07K16/12 ,  C07K14/22

    摘要： The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising these polypeptides. The invention further provides compositions for use in treating, preventing or detecting a bacterial infection, in particular vaccine compositions using the antigenic polypeptides. The invention further provides antibodies directed to said antigenic polypeptides.

    HUMAN MONOCLONAL ANTIBODY SPECIFIC FOR THE F PROTEIN OF RESPIRATORY SYNCYTIAL VIRUS (RSV)
    8.
    发明申请
    HUMAN MONOCLONAL ANTIBODY SPECIFIC FOR THE F PROTEIN OF RESPIRATORY SYNCYTIAL VIRUS (RSV) 审中-公开

    公开(公告)号：US20180030119A1

    公开(公告)日：2018-02-01

    申请号：US15523190

    申请日：2015-10-29

    申请人： Aridis Pharmaceuticals, Inc.

    发明人： Holger Koch ,  Simon Urwyler ,  Michael Rudolf ,  Vu Truong

    IPC分类号： C07K16/10

    CPC分类号： C07K16/1027 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2317/92

    摘要： This invention is directed to an antibody construct or fragment thereof derived from an RSV-infected human, such that the antibody construct binds with specificity to RSV fusion protein antigenic region II/A with an affinity of greater than 1×10−9M. Preferably, the antibody construct is capable of neutralizing RSV strains, including at least one RSV strain that is resistant to palivizumab. The invention further relates to nucleic acids encoding the antibody construct or portions thereof, and cell lines expressing the antibody. This invention further relates to methods for producing said antibody construct, and to the use of said anti-body construct for treating or preventing infection of a patient by RSV having a normal or mutated version of F protein.

    NOVEL TARGETS OF ACINETOBACTER BAUMANNII
    10.
    发明申请
    NOVEL TARGETS OF ACINETOBACTER BAUMANNII 审中-公开

    公开(公告)号：US20190000955A1

    公开(公告)日：2019-01-03

    申请号：US16124648

    申请日：2018-09-07

    申请人： Aridis Pharmaceuticals Inc.

    发明人： Simon Urwyler ,  Markus Haake ,  Michael Rudolf

    IPC分类号： A61K39/104 ,  C07K14/22 ,  C07K16/12 ,  C07K14/21

    摘要： The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising these polypeptides. The invention further provides compositions for use in treating, preventing or detecting a bacterial infection, in particular vaccine compositions using the antigenic polypeptides. The invention further provides antibodies directed to said antigenic polypeptides.