公开(公告)号：US20240408194A1

公开(公告)日：2024-12-12

申请号：US18701892

申请日：2022-10-20

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Nicholas Stephanopoulos ,  Yang Xu ,  Petr Sulc ,  Hao Yan ,  Rong Zheng

IPC: A61K39/215 ,  A61K39/00 ,  A61K39/385 ,  A61P37/04 ,  B82Y5/00

Abstract: The present disclosure relates to DNA nanocarriers and methods of use for stimulating an immune response in a host. In some embodiments, the DNA nanocarriers comprise SARS-CoV-2 surface glycoprotein.

公开(公告)号：US20230081282A1

公开(公告)日：2023-03-16

申请号：US17192305

申请日：2021-03-04

Applicant: Arizona Board of Regents on Behalf of Arizona State University

Inventor： Petr Sulc ,  Flavio Romano ,  John Russo ,  Lukas Kroc

IPC: G06F30/10

Abstract: A general framework which transforms the inverse problem of self-assembly of colloidal crystals into a Boolean satisfiability problem for which solutions can be found numerically is described herein. Given a reference structure and the desired number of components, our approach produces designs for which the target structure is an energy minimum, and also allows to exclude solutions that correspond to competing structures.

公开(公告)号：US20250146021A1

公开(公告)日：2025-05-08

申请号：US18726078

申请日：2023-01-09

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Nicholas Stephanopoulos ,  Karen Sue Anderson ,  Petr Sulc ,  Skyler Jennifer Wray Henry ,  Liangxiao Chen ,  Erik Poppleton ,  Hao Yan

IPC: C12N15/87 ,  C12N15/11 ,  C12N15/67

Abstract: Described herein is a DNA nanotechnology-based platform for the delivery of nucleic acids into cells. The delivery platform relies on compacting cargo mRNA and/or ssDNA into single folded nanostructures that act as the primary structural vehicle material for nanoparticle delivery to cells. The described compositions and methods provide an alternative to packaging mRNA or ssDNA into lipid nanoparticle vehicles, which have complex formulation properties. Also described herein are strategies for protecting mRNA and/or ssDNA cargo and helping these nucleic acid molecules escape the endosome into the cytoplasm using a cationic peptide-PEG coating.

公开(公告)号：US20240409669A1

公开(公告)日：2024-12-12

申请号：US18701901

申请日：2022-10-20

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Nicholas Stephanopoulos ,  Yang Xu ,  Petr Sulc ,  Hao Yan ,  Rong Zheng ,  Abhay Prasad

IPC: C07K19/00 ,  A61K38/00 ,  A61P31/14 ,  C07K14/005

Abstract: The present disclosure relates to DNA-peptide hybrid molecules. In some embodiments, the DNA-peptide hybrid molecules comprise target-specific binding peptides which selectively bind to SARS-COV-2 surface glycoprotein. Methods of using DNA-peptide hybrid molecules in the treatment of SARS-COV-2 infection are also provided.

公开(公告)号：US20240311527A1

公开(公告)日：2024-09-19

申请号：US18606649

申请日：2024-03-15

Applicant: Arizona Board of Regents on Behalf of Arizona State University ,  UNIVERSITÀ CA' FOSCARI ,  SAPIENZA UNIVERSITY OF ROME

Inventor： Petr Sulc ,  Michael Matthies ,  Flavio Romano ,  John Russo ,  Hao Liu

IPC: G06F30/20 ,  G16B15/10

CPC classification number: G06F30/20 ,  G16B15/10

Abstract: A computer-implemented system uses multiscale modeling and optimization algorithms to design DNA nanostructures that self-assemble into a target structure, such as a tetrastack lattice. The system converts a target structure into a Boolean Satisfiability problem and models nanostructure units as “patchy” nanostructure models, where patches encode kinetic properties that affect how each nanostructure model connects with other nanostructure models. The system iteratively simulates self-assembly of a plurality of nanostructure models into a nanostructure assembly model, and compares the nanostructure assembly model with the target structure to determine a set of optimal parameters (such as patch type assignments) for the nanostructure units that reliably result in self-assembly into the target structure.