公开(公告)号：US11931460B2

公开(公告)日：2024-03-19

申请号：US17529930

申请日：2021-11-18

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Kaushal Rege ,  Rajeshwar Nitiyanandan ,  Tanya Nanda

IPC: A61K35/12 ,  A61K9/127 ,  A61K47/69

CPC classification number: A61K9/1273 ,  A61K35/12 ,  A61K47/6903

Abstract: The instant disclosure is directed to compositions comprising an encapsulated spheroid, and methods of making and using the same. A composition may comprise a spheroid comprising a plurality of cells and aminoglycoside antibiotic-derived hydrogel beads, wherein the spheroid is encapsulated by the aminoglycoside antibiotic-derived hydrogel beads to form an encapsulated spheroid. A method may comprise administering the composition to a subject in need thereof. Another method may comprise administering a compound to the encapsulated spheroid. A method of creating an encapsulated spheroid may comprise coating a surface with an aminoglycoside antibiotic-derived hydrogel, culturing a plurality of cells on the surface, thereby creating a spheroid, and encapsulating the spheroid with a plurality of aminoglycoside antibiotic-derived hydrogel beads.