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公开(公告)号：US10183055B2
公开(公告)日：2019-01-22
申请号：US15401944
申请日：2017-01-09
发明人： Meredith Hay , John Konhilas , Robin L. Polt , Todd Vanderah , Brittany Forte , Tally Milnes , Evan Jones , Lajos Szabo
摘要： The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/or impairment, pain, and traumatic brain injury.
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2.发明申请ANG-(1-7) Derivative Oligopeptides and Methods for Using and Producing the Same 有权ANG-（1-7）衍生寡肽及其使用和生产方法公开(公告)号：US20160347794A1
公开(公告)日：2016-12-01
申请号：US15134073
申请日：2016-04-20
发明人： Meredith Hay , John Konhilas , Robin L. Polt
摘要： The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.
摘要翻译： 本发明提供了寡肽，特别是Ang-（1-7）衍生物及其使用和制备方法。 在一个具体实施方案中，本发明的寡肽与天然Ang-（1-7）相比具有更高的血脑屏障穿透和/或体内半衰期，从而使得本发明的寡肽可用于各种各样的 临床应用包括治疗认知功能障碍和/或损伤。
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3.发明申请ANG-(1-7) DERVIATIVE OLIGOPEPTIDES AND METHODS FOR USING AND PRODUCING THE SAME 有权ANG-（1-7）衍生寡核苷酸及其使用和生产方法公开(公告)号：US20160016996A1
公开(公告)日：2016-01-21
申请号：US14801557
申请日：2015-07-16
发明人： Meredith Hay , John Konhilas , Robin L. Polt
摘要： The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.
摘要翻译： 本发明提供了寡肽，特别是Ang-（1-7）衍生物及其使用和制备方法。 在一个具体实施方案中，本发明的寡肽与天然Ang-（1-7）相比具有更高的血脑屏障穿透和/或体内半衰期，从而使得本发明的寡肽可用于多种 临床应用包括治疗认知功能障碍和/或损伤。
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公开(公告)号：US20230226140A1
公开(公告)日：2023-07-20
申请号：US18151957
申请日：2023-01-09
发明人： Meredith Hay , John Konhilas , Robin L. Polt , Todd Vanderah , Brittany Forte , Tally Milnes , Evan Jones , Lajos Szabo
CPC分类号： A61K38/085 , C07K7/06 , C07K7/14 , C07K9/001
摘要： The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and pain.
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公开(公告)号：US20200262870A1
公开(公告)日：2020-08-20
申请号：US16751120
申请日：2020-01-23
发明人： Meredith Hay , John Konhilas , Robin L. Polt , Evan Jones , Lajos Szabo
摘要： The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.
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公开(公告)号：US20190351009A1
公开(公告)日：2019-11-21
申请号：US16208731
申请日：2018-12-04
发明人： Meredith Hay , John Konhilas , Robin L. Polt , Todd Vanderah , Brittany Forte , Tally Milnes , Evan Jones , Lajos Szabo
摘要： The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/or impairment, pain, and traumatic brain injury.
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公开(公告)号：US20170304391A1
公开(公告)日：2017-10-26
申请号：US15401944
申请日：2017-01-09
发明人： Meredith Hay , John Konhilas , Robin L. Polt , Todd Vanderah , Brittany Forte , Tally Milnes , Evan Jones
IPC分类号： A61K38/08
CPC分类号： A61K38/085 , C07K7/06 , C07K7/14 , C07K9/001
摘要： The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/or impairment, pain, and traumatic brain injury.
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公开(公告)号：US09796759B2
公开(公告)日：2017-10-24
申请号：US14801557
申请日：2015-07-16
发明人： Meredith Hay , John Konhilas , Robin L. Polt , Evan Jones
摘要： The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.
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公开(公告)号：US12116423B2
公开(公告)日：2024-10-15
申请号：US17461115
申请日：2021-08-30
发明人： Meredith Hay , John Konhilas , Robin L. Polt , Evan Jones , Lajos Szabo
摘要： The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.
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公开(公告)号：US11104706B2
公开(公告)日：2021-08-31
申请号：US16751120
申请日：2020-01-23
发明人： Meredith Hay , John Konhilas , Robin L. Polt , Evan Jones , Lajos Szabo
摘要： The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.
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