-
公开(公告)号：US11826387B2
公开(公告)日：2023-11-28
申请号：US17369075
申请日：2021-07-07
申请人： PROTOKINETIX INC.
发明人： Lachlan Grant Young
IPC分类号： A61K35/30 , A61K31/16 , A61K31/164 , C07K14/00 , C07K5/08 , C07K9/00 , A61K31/335 , A61P27/00 , A61K38/14 , C07K5/10
CPC分类号： A61K35/30 , A61K31/16 , A61K31/164 , A61K31/335 , A61K38/14 , A61P27/00 , C07K5/08 , C07K5/0827 , C07K9/001 , C07K14/00 , C07K5/1027
摘要： The present disclosure relates to an in vitro method for enhancing engraftment of neurosensory precursor cell comprising the step of contacting an isolated neurosensory precursor cell prior to a transplantation in a subject in need thereof, with a gem-difluorinated C-glycopeptide compound of general formula I, or a pharmaceutically acceptable base, addition salt with an acid, hydrate or solvate thereof:
-
公开(公告)号：US20180344805A1
公开(公告)日：2018-12-06
申请号：US15771692
申请日：2015-11-15
发明人： Graham GRIFFITHS , Stephen SHAW , Nicolai Vladimirovich BOVIN , Alexander Borisovich TUZIKOV , Elena Yurievna KORCHAGINA , Stephen HENRY
IPC分类号： A61K38/14 , C07K9/00 , C07K14/00 , C07H15/04 , A61K31/7028 , A61K38/16 , A61K45/06 , A61P35/00
CPC分类号： C07H15/10 , A61K31/7032 , C07K9/001
摘要： The invention relates to novel glycolipid compounds and pharmaceutical compositions comprising said glycolipids and to processes for preparing said glycolipids. The invention also relates to said glycolipids for use in treating tumours and methods of treating tumours using said glycolipids.
-
公开(公告)号：US20180264125A1
公开(公告)日：2018-09-20
申请号：US15894897
申请日：2018-02-12
发明人： Ning Tsao , Wei-Chung Chang
IPC分类号： A61K47/64
CPC分类号： A61K47/64 , A61K47/61 , A61K47/645 , A61K51/06 , A61K51/08 , C07K9/001 , C08G69/10 , C08G69/40 , C08G69/48
摘要： A glycopeptide composition including a plurality of glycopeptides and a therapeutic agent or diagnostic compound is provided. Each of the glycopeptide includes a polysaccharide moiety connected to a peptide moiety, and the polysaccharide moiety is covalently bounded to the peptide moiety via a fixed connection point, wherein the fixed connection point is the same in each of the glycopeptide, and the therapeutic agent or diagnostic is conjugated to each of the glycopeptide.
-
公开(公告)号：US20180055078A1
公开(公告)日：2018-03-01
申请号：US15558403
申请日：2016-03-08
申请人： NESTEC S.A.
CPC分类号： A23L27/215 , A23L23/00 , A23L27/00 , A23V2002/00 , C07K1/1077 , C07K5/06026 , C07K9/001
摘要： The present invention relates to a method for making a sugar-dipeptide conjugate. In particular the invention concerns a method for making a sugar-dipeptide conjugate comprising forming a liquid eutectic mixture of at least two compounds solid at 25° C. and water, and heating the liquid eutectic mixture; wherein the liquid eutectic mixture comprises a dipeptide and a reducing sugar. A further aspect of the invention is a method for preparing a food product.
-
公开(公告)号：US20180028596A9
公开(公告)日：2018-02-01
申请号：US15401944
申请日：2017-01-09
发明人： Meredith Hay , John Konhilas , Robin L. Polt , Todd Vanderah , Brittany Forte , Tally Milnes , Evan Jones
IPC分类号： A61K38/08
CPC分类号： A61K38/085 , C07K7/06 , C07K7/14 , C07K9/001
摘要： The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/or impairment, pain, and traumatic brain injury.
-
公开(公告)号：US09670251B2
公开(公告)日：2017-06-06
申请号：US15134073
申请日：2016-04-20
发明人： Meredith Hay , John Konhilas , Robin L. Polt , Evan Jones
摘要： The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment.
-
公开(公告)号：US20170119875A1
公开(公告)日：2017-05-04
申请号：US15316124
申请日：2015-06-05
申请人： Regan James Anderson , Benjamin Jason Compton , Colin Malcolm Hayman , Ian Francis Hermans , Karen Anne Johnston , Gavin Frank Painter
发明人： Regan James Anderson , Benjamin Jason Compton , Colin Malcolm Hayman , Ian Francis Hermans , Karen Anne Johnston , Gavin Frank Painter
IPC分类号： A61K39/385 , A61K39/39 , A61K39/00 , C07H15/04 , C07H15/18
CPC分类号： A61K39/385 , A61K39/0011 , A61K39/39 , A61K47/542 , A61K47/549 , A61K47/65 , A61K2039/55511 , A61K2039/60 , C07H15/04 , C07H15/06 , C07H15/18 , C07K9/001
摘要： The invention relates to amino sphingoglycolipid analogues and peptide derivatives thereof, compositions comprising these compounds and methods of treating or preventing diseases or conditions using such compounds, especially diseases or conditions relating to cancer, infection, atopic disorders, autoimmune disease or diabetes.
-
8.发明申请GLYCOPEPTIDE DERIVATIVES FOR THE PRESERVATION AND PROTECTION OF BIOLOGICAL MATERIALS AND MICROORGANISMS 审中-公开用于保护和保护生物材料和微生物的糖苷衍生物公开(公告)号：US20170015709A1
公开(公告)日：2017-01-19
申请号：US15125725
申请日：2015-03-17
申请人： TFCHEM
CPC分类号： C07K9/001 , A01N1/0226 , A61K8/64 , A61K8/69 , A61K31/7028 , A61K38/14 , A61Q19/00 , A61Q19/08 , C07H7/02 , C07H15/04 , C07H15/18 , C07K5/06052 , C07K5/06191
摘要： The present invention relates to a compound of the following formula (I): in which at least one and only one group chosen among R5, R6 and R7 is a group of the following formula: The present invention relates also to uses thereof for preservation and/or protection and/or regeneration of biological materials and or microorganisms and for cosmetic or dermato logical applications such as anti-aging, skin protection and skin regeneration; to culture, storage and/or preservation media comprising such a compound; to cosmetic or dermato logical compositions comprising such a compound; to processes for preparing such a compound; and to synthesis intermediates.
摘要翻译： 本发明涉及下式（I）的化合物：其中R5，R6和R7中至少一个且仅一个选自下式的基团：本发明还涉及其用于保存和 /或生物材料和/或微生物的保护和/或再生，以及化妆品或皮肤用途的应用，例如抗衰老，皮肤保护和皮肤再生; 包含这种化合物的培养物，储存和/或保存介质; 涉及包含这种化合物的化妆品或皮肤组合物; 制备这种化合物的方法; 并合成中间体。
-
公开(公告)号：US20160243218A1
公开(公告)日：2016-08-25
申请号：US14982734
申请日：2015-12-29
申请人： UNIVERSITY OF MIAMI
发明人： Eli Gilboa
IPC分类号： A61K39/385 , A61K47/48
CPC分类号： A61K39/385 , A61K47/64 , C07K9/001 , C07K9/006 , C12N15/113 , C12N2310/3513 , C12N2320/32 , C12N2310/531 , C12N2310/14 , C12N2310/3519 , C12N2310/16
摘要： Compositions for inducing or enhancing antigenicity of a target cell by modulating the nonsense mediated decay pathway in the target cell. The compositions comprise one or more cell binding ligands providing specificity and delivery of an oligonucleotide or other molecule to the target. These compositions have broad applicability in the treatment of many diseases.
-
10.发明授权公开(公告)号：US09303068B2
公开(公告)日：2016-04-05
申请号：US14092262
申请日：2013-11-27
发明人： Carolyn R. Bertozzi , Mary Sloan Siegrist Palmore , John C. Jewett , Chelsea G. Gordon , Peyton Shieh
CPC分类号： A61K39/385 , A61K47/64 , A61K47/646 , A61K2039/6068 , C07K9/00 , C07K9/001 , C07K14/195 , C07K14/4725 , C12N1/20 , C12Q1/025 , C12Q1/18 , G01N2333/195
摘要： The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via a linker.
摘要翻译： 本公开提供了修饰的细菌和包含修饰的D-氨基酸的修饰的肽聚糖; 包含改性细菌或肽聚糖的组合物; 以及使用改良细菌或肽聚糖的方法。 修饰的D-氨基酸包括生物正交官能团如叠氮化物，炔烃或降冰片烯基团。 还提供了通过接头与目的分子缀合的经修饰的肽聚糖。
-
-
-
-
-
-
-
-
-
搜索结果
245 条记录 (耗时 0.036 秒)
