公开(公告)号：US08118864B1

公开(公告)日：2012-02-21

申请号：US10854014

申请日：2004-05-25

申请人： Arnold M. Escano ,  Joanne L. Parker ,  Rodney Reinhardt

发明人： Arnold M. Escano ,  Joanne L. Parker ,  Rodney Reinhardt

IPC分类号： A61F2/82

CPC分类号： A61F2/07 ,  A61F2/848 ,  A61F2/89 ,  A61F2002/065 ,  A61F2002/075 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0067

摘要： An endovascular graft of the present invention embodies a graft system utilizing the textile fabric of the prosthesis for drug storage and delivery. These drug-eluting devices involve treating the textile fabric with therapeutic agents to provide a method of delivery to both the outer surface of the graft and the inner surface of the graft. An endovascular graft system having a fuzz texturing on the outer periphery of the graft where the texturing includes a therapeutic agent coating applied to the texturing material is also contemplated. An expandable attachment frame further includes drug storage and delivery capabilities in the cavities formed in the V-hooks and apices. Therapeutic agents can also included in the radiopaque coating or loading to serve as a reservoir for controlled drug delivery.

摘要翻译： 本发明的血管内移植物体现了利用假体的纺织织物进行药物储存和递送的移植系统。 这些药物洗脱装置包括用治疗剂处理纺织织物以提供递送到移植物的外表面和移植物的内表面的方法。 还考虑了在移植物的外周上具有绒毛纹理的血管内移植物系统，其中纹理包括施加到纹理材料的治疗剂涂层。 可扩展的附接框架还包括在V形钩和顶点中形成的空腔中的药物储存和递送能力。 治疗剂也可以包括在不透射线的涂层或装载中以用作用于受控药物递送的储库。