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公开(公告)号：US20200317665A1
公开(公告)日：2020-10-08
申请号：US16835702
申请日：2020-03-31
申请人： Array BioPharma Inc.
发明人： James F. BLAKE , Mark Laurence BOYS , Mark Joseph CHICARELLI , Adam W. COOK , Mohamed S. A. ELSAYED , Jay Bradford FELL , John P. FISCHER , Ronald Jay HINKLIN , Yutong JIANG , Oren T. MCNULTY , Macedonio J. MEJIA , Martha E. RODRIGUEZ , Christina E. WONG
IPC分类号： C07D471/04 , C07D401/14 , C07D513/10 , C07D471/10 , A61P35/00
摘要： Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US20220112214A1
公开(公告)日：2022-04-14
申请号：US17274990
申请日：2019-09-06
申请人： ARRAY BIOPHARMA INC.
发明人： James F. BLAKE , Donghua DAI , Julia HAAS , Yutong JIANG , Dean KAHN , Gabrielle R. KOLAKOWSKI , Elizabeth A. MCFADDIN , Megan L. MCKENNEY , Andrew T. METCALF , David A. MORENO , Brett PRIGARO , Ginelle A. RAMANN , Li REN , Shane M. WALLS , Hailong ZHANG
IPC分类号： C07D498/22 , C07D513/22 , C07D498/14 , A61K45/06 , A61K31/554 , A61K31/55 , A61K31/519 , C07D487/14 , A61P35/00
摘要： Provided herein are compounds of the Formula (I): (I) and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein Rx, Ry, W, X, Y, Z, Ring A and (AA) have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
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公开(公告)号：US20230373999A1
公开(公告)日：2023-11-23
申请号：US18048834
申请日：2022-10-21
发明人： Matthew Arnold MARX , James Gail CHRISTENSEN , Christopher Ronald SMITH , James F. BLAKE , Laurence E. BURGESS , Mark Joseph CHICARELLI , Adam COOK , Jay Bradford FELL , John P. FISCHER , Macedonio J. MEJIA , Martha E. RODRIGUEZ , Pavel SAVECHENKOV , Tony P. TANG , Guy P.A. VIGERS
IPC分类号： C07D471/04 , A61P35/00 , C07D491/08
CPC分类号： C07D471/04 , A61P35/00 , C07D491/08
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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![SUBSTITUTED PYRAZOLYL[4,3-C]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS](/abs-image/US/2020/10/29/US20200339579A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200339579A1
公开(公告)日：2020-10-29
申请号：US16962305
申请日：2019-01-18
申请人： Array BioPharma Inc.
发明人： Shane M. WALLS , LI REN , Ginelle A. RAMANN , David A. MORENO , Andrew T. METCALF , Elizabeth A. MCFADDIN , Gabrielle R. KOLAKOWSKI , James F. BLAKE , Donghua DAI , Julia HAAS , Yutong JIANG , Dean KAHN
IPC分类号： C07D471/04 , C07F9/6561
摘要： Provided herein are compounds of the Formula I: and tautomers and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2 and R3 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
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公开(公告)号：US20240101553A1
公开(公告)日：2024-03-28
申请号：US18230580
申请日：2023-08-04
发明人： Matthew Arnold MARX , James Gail CHRISTENSEN , Christopher Ronald SMITH , James F. BLAKE , Laurence E. BURGESS , Mark Joseph CHICARELLI , Adam COOK , Jay Bradford FELL , John P. FISCHER , Macedonio J. MEJIA , Martha E. RODRIGUEZ , Pavel SAVECHENKOV , Tony P. TANG , Guy P.A. VIGERS
IPC分类号： C07D471/04 , A61P35/00 , C07D491/08
CPC分类号： C07D471/04 , A61P35/00 , C07D491/08
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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![SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS](/abs-image/US/2022/10/06/US20220313676A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220313676A1
公开(公告)日：2022-10-06
申请号：US17108528
申请日：2020-12-01
申请人： Array Biopharma Inc.
发明人： Steven W. ANDREWS , Sean ARONOW , James F. BLAKE , Barbara J. BRANDHUBER , James COLLIER , Adam COOK , Julia HAAS , Yutong JIANG , Gabrielle R. KOLAKOWSKI , Elizabeth A. MCFADDIN , Megan L. MCKENNEY , Oren T. MCNULTY , Andrew T. METCALF , David A. MORENO , Ginelle A. RAMANN , Tony P. TANG , Li REN , Shane M. WALLS
IPC分类号： A61K31/4545 , A61K31/4162 , C07D471/04 , A61P1/00 , A61P35/00 , A61P35/02 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , A61P1/12
摘要： Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
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![SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES COMPOUNDS AS RET KINASE INHIBITORS](/abs-image/US/2020/10/29/US20200339589A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200339589A1
公开(公告)日：2020-10-29
申请号：US16962345
申请日：2019-01-18
申请人： Array BioPharma Inc.
发明人： James F. BLAKE , Donghua DAI , Julia HAAS , Yutong JIANG , Gabrielle R. KOLAKOWSKI , Elizabeth A. MCFADDIN , Megan L. MCKENNEY , Andrew T. METCALF , David A. MORENO , Brett PRIGARO , Ginelle A. RAMANN , Li REN
IPC分类号： C07D487/04
摘要： Provided herein are compounds of the Formula I: [INSERT FORMULA I] and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2 and Ry have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
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![SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS](/abs-image/US/2023/03/23/US20230090520A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230090520A1
公开(公告)日：2023-03-23
申请号：US17530702
申请日：2021-11-19
发明人： Steven W. ANDREWS , Sean ARONOW , James F. BLAKE , Barbara J. BRANDHUBER , Adam COOK , Julia HAAS , Yutong JIANG , Gabrielle R. KOLAKOWSKI , Elizabeth A. MCFADDIN , Megan L. MCKENNEY , Oren T. MCNULTY , Andrew T. METCALF , David A. MORENO , Tony P. TANG , Li REN
IPC分类号： A61K31/496 , C07D471/04 , A61P1/12 , A61P35/04 , C07D519/00 , A61P35/02 , A61P35/00 , A61K31/444 , A61K31/4985 , A61K31/4995 , A61K31/506 , A61K31/5377 , A61K45/06 , A61K31/551
摘要： Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
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![SUBSTITUTED PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS](/abs-image/US/2022/04/21/US20220119396A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220119396A1
公开(公告)日：2022-04-21
申请号：US17514684
申请日：2021-10-29
申请人： Array BioPharma Inc.
发明人： Steven W. ANDREWS , James F. BLAKE , Julia HAAS , Yutong JIANG , Gabrielle R. KOLAKOWSKI , David A. MORENO , Li REN , Shane M. WALLS
IPC分类号： C07D487/04
摘要： Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.
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公开(公告)号：US20210269432A1
公开(公告)日：2021-09-02
申请号：US16099398
申请日：2017-05-17
发明人： John P. FISCHER , Jay Bradford FELL , James F. BLAKE , Ronald Jay HINKLIN , Macedonio J. MEJIA , Erik James HICKEN , Mark Joseph CHICARELLI , John J. GAUDINO , Guy P.A. VIGERS , Laurence E. BURGESS , Matthew Arnold MARX , James Gail CHRISTENSEN , Matthew Randolf LEE , Pavel SAVECHENKOV , Henry J. ZECCA , Tony P. TANG
IPC分类号： C07D471/04 , C07D519/00 , A61P35/00
摘要： The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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