公开(公告)号：US10287582B2

公开(公告)日：2019-05-14

申请号：US15359894

申请日：2016-11-23

申请人： Arrowhead Pharmaceuticals, Inc.

发明人： Gregory Hinkle ,  Satyanarayana Kuchimanchi ,  Stuart Milstein ,  Markus Warmuth ,  Wenlai Zhou ,  Ping Zhu ,  Tracy S. Zimmermann

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  C07H21/02

摘要： The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

公开(公告)号：US20170073678A1

公开(公告)日：2017-03-16

申请号：US15359894

申请日：2016-11-23

申请人： Arrowhead Pharmaceuticals, Inc.

发明人： Gregory Hinkle ,  Satyanarayana Kuchimanchi ,  Stuart Milstein ,  Markus Warmuth ,  Wenlai Zhou ,  Ping Zhu ,  Tracy S. Zimmermann

IPC分类号： C12N15/113 ,  A61K45/06 ,  A61K31/713

CPC分类号： C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  C07H21/02 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2320/31 ,  C12N2320/51 ,  C12N2320/53 ,  Y02A50/467 ,  C12N2310/3521

摘要： The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

摘要翻译： 本公开涉及使用治疗有效量的RNAi剂对HSF治疗热休克因子1（HSF1）相关疾病如癌症和病毒性疾病的方法。

公开(公告)号：US20190276827A1

公开(公告)日：2019-09-12

申请号：US16411805

申请日：2019-05-14

申请人： Arrowhead Pharmaceuticals, Inc.

发明人： Gregory Hinkle ,  Satyanarayana Kuchimanchi ,  Stuart Milstein ,  Markus Warmuth ,  Wenlai Zhou ,  Ping Zhu ,  Tracy S. Zimmermann

IPC分类号： C12N15/113 ,  A61K45/06 ,  A61K31/713 ,  C07H21/02

摘要： The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

公开(公告)号：US12091661B2

公开(公告)日：2024-09-17

申请号：US17714272

申请日：2022-04-06

申请人： Arrowhead Pharmaceuticals, Inc.

发明人： Gregory Hinkle ,  Satyanarayana Kuchimanchi ,  Stuart Milstein ,  Markus Warmuth ,  Wenlai Zhou ,  Ping Zhu ,  Tracy S. Zimmermann

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  A61P19/02 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22 ,  C07H21/02

CPC分类号： C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  A61P19/02 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22 ,  C07H21/02 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2320/31 ,  C12N2320/51 ,  C12N2320/53 ,  Y02A50/30 ,  C12N2310/321 ,  C12N2310/3521

摘要： The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

公开(公告)号：US20220380775A1

公开(公告)日：2022-12-01

申请号：US17714272

申请日：2022-04-06

申请人： Arrowhead Pharmaceuticals, Inc.

发明人： Gregory Hinkle ,  Satyanarayana Kuchimanchi ,  Stuart Milstein ,  Markus Warmuth ,  Wenlai Zhou ,  Ping Zhu ,  Tracy S. Zimmermann

IPC分类号： C12N15/113 ,  A61K45/06

摘要： The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

公开(公告)号：US11091761B2

公开(公告)日：2021-08-17

申请号：US16411805

申请日：2019-05-14

申请人： Arrowhead Pharmaceuticals, Inc.

发明人： Gregory Hinkle ,  Satyanarayana Kuchimanchi ,  Stuart Milstein ,  Markus Warmuth ,  Wenlai Zhou ,  Ping Zhu ,  Tracy S. Zimmermann

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61P31/12 ,  A61P31/18 ,  A61P19/02 ,  A61P31/20 ,  A61P29/00 ,  A61P31/22 ,  A61K45/06 ,  C07H21/02

摘要： The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.