公开(公告)号：US07937134B2

公开(公告)日：2011-05-03

申请号：US11752463

申请日：2007-05-23

申请人： Arthur E. Uber ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski ,  Alan Hirschman

发明人： Arthur E. Uber ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski ,  Alan Hirschman

IPC分类号： A61B6/00

CPC分类号： A61B8/481 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1723 ,  A61M2205/581 ,  A61M2205/80 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468

摘要： A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.

摘要翻译： 用于产生患者的对比度增强的医学图像的系统包括对比度或增强介质的源，与对比度或增强介质源流体连接的加压单元，可操作以将能量施加到所述对比度或增强介质的区域的能量源 患者，成像单元，其基于由施加到患者的区域的能量产生的信号以及控制单元提供患者的内部视图的视觉显示。 在一个实施例中，该信号受到患者中的对比度或增强介质的状况的影响。 为了控制程序，控制单元基于该信号来调整患者的对比度或增强介质的状况。 通信接口优选地实现喷射器子系统和成像子系统之间的信息。

公开(公告)号：US08160679B2

公开(公告)日：2012-04-17

申请号：US12477456

申请日：2009-06-03

申请人： Arthur E. Uber ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski ,  Alan Hirschman

发明人： Arthur E. Uber ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski ,  Alan Hirschman

IPC分类号： A61B6/00

CPC分类号： A61B8/481 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1723 ,  A61M2205/581 ,  A61M2205/80 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468

摘要： A method of coordinating an imaging procedure and an injection procedure, the method comprising the steps of providing an injector system having first and second pressurizing units for pressurizing a contrast medium and a diluent for injection into a patient; providing an imaging system for producing an image of an internal region of the patient from a signal resulting from energy applied to the patient; and providing a data interface interconnecting the injector and imaging systems for enabling exchange of digital information therebetween such that the digital information transmitted between the systems is usable to enable closed loop control of at least one of the injection and the imaging procedures during which the contrast medium and the diluent injected into the patient is adjustable so as to achieve a desired level of enhancement within the internal region of the patient of which the images are acquired during the imaging procedure.

摘要翻译： 一种协调成像过程和注射程序的方法，所述方法包括以下步骤：提供具有用于加压造影剂的第一和第二加压单元和用于向患者注射的稀释剂的注射器系统; 提供成像系统，用于从施加到患者的能量产生的信号产生患者的内部区域的图像; 并且提供互连注射器和成像系统的数据接口，以使得能够在其间进行数字信息的交换，使得在系统之间传输的数字信息可用于对注射和成像过程中的至少一个进行闭环控制， 并且注射到患者体内的稀释剂是可调节的，以便在成像过程期间获取图像的患者的内部区域内实现期望的增强水平。

公开(公告)号：US20090247866A1

公开(公告)日：2009-10-01

申请号：US12477456

申请日：2009-06-03

申请人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

发明人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

IPC分类号： A61B6/00

CPC分类号： A61B8/481 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1723 ,  A61M2205/581 ,  A61M2205/80 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468

摘要： A method of coordinating an imaging procedure and an injection procedure, the method comprising the steps of providing an injector system having first and second pressurizing units for pressurizing a contrast medium and a diluent for injection into a patient; providing an imaging system for producing an image of an internal region of the patient from a signal resulting from energy applied to the patient; and providing a data interface interconnecting the injector and imaging systems for enabling exchange of digital information therebetween such that the digital information transmitted between the systems is usable to enable closed loop control of at least one of the injection and the imaging procedures during which the contrast medium and the diluent injected into the patient is adjustable so as to achieve a desired level of enhancement within the internal region of the patient of which the images are acquired during the imaging procedure.

摘要翻译： 一种协调成像过程和注射程序的方法，所述方法包括以下步骤：提供具有用于加压造影剂的第一和第二加压单元和用于向患者注射的稀释剂的注射器系统; 提供成像系统，用于从施加到患者的能量产生的信号产生患者的内部区域的图像; 并且提供互连注射器和成像系统的数据接口，以使得能够在其间进行数字信息的交换，使得在系统之间传输的数字信息可用于对注射和成像过程中的至少一个进行闭环控制， 并且注射到患者体内的稀释剂是可调节的，以便在成像过程期间获取图像的患者的内部区域内实现期望的增强水平。

公开(公告)号：US20090326370A1

公开(公告)日：2009-12-31

申请号：US12534987

申请日：2009-08-04

申请人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

发明人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

IPC分类号： A61B6/00

CPC分类号： A61B8/481 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1723 ,  A61M2205/581 ,  A61M2205/80 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468

摘要： A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.

摘要翻译： 用于产生患者的对比度增强的医学图像的系统包括对比度或增强介质的源，与对比度或增强介质源流体连接的加压单元，可操作以将能量施加到所述对比度或增强介质的区域的能量源 患者，成像单元，其基于由施加到患者的区域的能量产生的信号以及控制单元提供患者的内部视图的视觉显示。 在一个实施例中，该信号受到患者中的对比度或增强介质的状况的影响。 为了控制程序，控制单元基于该信号来调整患者的对比度或增强介质的状况。 通信接口优选地实现喷射器子系统和成像子系统之间的信息。

公开(公告)号：US06397098B1

公开(公告)日：2002-05-28

申请号：US09300326

申请日：1999-04-27

申请人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

发明人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

IPC分类号： A61B600

CPC分类号： A61B8/481 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1723 ,  A61M2205/581 ,  A61M2205/80 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468

摘要： A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.

公开(公告)号：US08055328B2

公开(公告)日：2011-11-08

申请号：US12534987

申请日：2009-08-04

申请人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

发明人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

IPC分类号： A61B6/00

CPC分类号： A61B8/481 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1723 ,  A61M2205/581 ,  A61M2205/80 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468

摘要： An interface unit enables communication with an injector system that is used for pressurizing a fluid medium for injection into a patient during an injection procedure. The interface unit includes a processor and a storage unit. The processor controls operation of the interface unit and enables exchange of digital information between the interface unit and the injector system. The storage unit, under control of the processor, records the digital information gathered from the injector system during communication therewith. The digital information includes at least injection profile, history and dose data pertaining to the injection procedure. The processor enables at least the injection profile, history and dose data of the digital information recorded within the storage unit of the interface unit to be communicable to at least one of an imaging system linked thereto and an external device linked thereto.

摘要翻译： 接口单元使得能够与注射器系统进行通信，所述注射器系统在注射过程期间用于对用于注射到患者中的流体介质进行加压。 接口单元包括处理器和存储单元。 处理器控制接口单元的操作，并能够在接口单元和喷射器系统之间交换数字信息。 在处理器的控制下，存储单元在与其通信期间记录从喷射器系统收集的数字信息。 数字信息至少包括与注射程序相关的注射分布，历史和剂量数据。 处理器至少使记录在接口单元的存储单元内的数字信息的喷射轮廓，历史和剂量数据能够连接到与其相连的成像系统和与其相连的外部装置中的至少一个。

公开(公告)号：US06970735B2

公开(公告)日：2005-11-29

申请号：US10134858

申请日：2002-04-29

申请人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

发明人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

IPC分类号： A61B6/00 ,  A61B8/00 ,  A61M5/00 ,  A61M5/145 ,  A61M5/172

CPC分类号： A61B8/481 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1723 ,  A61M2205/581 ,  A61M2205/80 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468

摘要： A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.

摘要翻译： 用于产生患者的对比度增强的医学图像的系统包括对比度或增强介质的源，与对比度或增强介质源流体连接的加压单元，可操作以将能量施加到所述对比度或增强介质的区域的能量源 患者，成像单元，其基于由施加到患者的区域的能量产生的信号以及控制单元提供患者的内部视图的视觉显示。 在一个实施例中，该信号受到患者中的对比度或增强介质的状况的影响。 为了控制程序，控制单元基于该信号来调整患者的对比度或增强介质的状况。 通信接口优选地实现喷射器子系统和成像子系统之间的信息。

公开(公告)号：US07672710B2

公开(公告)日：2010-03-02

申请号：US11196806

申请日：2005-08-02

申请人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Karen Zelenski

发明人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Karen Zelenski

IPC分类号： A61B6/00 ,  A61M5/30 ,  A61M5/00

CPC分类号： A61B8/481 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1723 ,  A61M2205/581 ,  A61M2205/80 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468

摘要： A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.

摘要翻译： 用于产生患者的对比度增强的医学图像的系统包括对比度或增强介质的源，与对比度或增强介质源流体连接的加压单元，可操作以将能量施加到所述对比度或增强介质的区域的能量源 患者，成像单元，其基于由施加到患者的区域的能量产生的信号以及控制单元提供患者的内部视图的视觉显示。 在一个实施例中，该信号受到患者中的对比度或增强介质的状况的影响。 为了控制程序，控制单元基于该信号来调整患者的对比度或增强介质的状况。 通信接口优选地实现注射器子系统和成像子系统之间的信息。

公开(公告)号：US07351221B2

公开(公告)日：2008-04-01

申请号：US11394946

申请日：2006-03-31

申请人： Frederick W. Trombley, III ,  Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  Alan D. Hirschman

发明人： Frederick W. Trombley, III ,  Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  Alan D. Hirschman

IPC分类号： A61M37/00 ,  B01F5/00

CPC分类号： A61M5/142 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/14566 ,  A61M5/445 ,  A61M2205/3673 ,  B01F9/103 ,  B01F13/005

摘要： A system for dispensing a medium includes at least a first container to hold the medium, a pressurizing device, such as a pump, in fluid connection with the container for pressurizing the medium, and an agitation mechanism or device to maintain the components of the medium in a mixed state. The container and the pressurizing device can be separate units, as in the case of an bag or bottle in fluid connection with a peristaltic or other type of pump. The container and the pump can also be combined in a single unit, as in the case of a syringe, wherein the syringe barrel of the syringe acts to contain the medium and the syringe plunger pressurizes the medium within the syringe barrel. A method of injecting a multi-component medium includes the step of agitating the medium (for example, as described above) before or during an injection procedure to maintain the components of the medium in a mixed state.

摘要翻译： 用于分配介质的系统至少包括用于保持介质的第一容器，与容器流体连接的用于对介质加压的加压装置，例如泵，以及用于维持介质的组分的搅拌机构或装置 处于混合状态。 容器和加压装置可以是分离的单元，如在与蠕动或其它类型的泵流体连接的袋或瓶的情况下。 容器和泵也可以在单个单元中组合，如在注射器的情况下，其中注射器的注射器筒用于容纳介质，并且注射器柱塞对注射器筒内的介质加压。 注射多组分培养基的方法包括在注射过程之前或过程中搅拌培养基（例如，如上所述）以将培养基的组分维持在混合状态的步骤。

公开(公告)号：US06575930B1

公开(公告)日：2003-06-10

申请号：US09267237

申请日：1999-03-12

申请人： Frederick W. Trombley, III ,  Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  Alan D. Hirschman

发明人： Frederick W. Trombley, III ,  Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  Alan D. Hirschman

IPC分类号： A61M3700

CPC分类号： A61M5/142 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/14566 ,  A61M5/445 ,  A61M2205/3673 ,  B01F9/103 ,  B01F13/005

摘要： A system for dispensing a medium includes at least a first container to hold the medium, a pressurizing device, such as a pump, in fluid connection with the container for pressurizing the medium, and an agitation mechanism or device to maintain the components of the medium in a mixed state. The container and the pressurizing device can be separate units, as in the case of an bag or bottle in fluid connection with a peristaltic or other type of pump. The container and the pump can also be combined in a single unit, as in the case of a syringe, wherein the syringe barrel of the syringe acts to contain the medium and the syringe plunger pressurizes the medium within the syringe barrel. A method of injecting a multi-component medium includes the step of agitating the medium (for example, as described above) before or during an injection procedure to maintain the components of the medium in a mixed state.