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    Method of preparing a medium with bubbles formed therein for contemporaneous injection
    7.
    发明授权
    Method of preparing a medium with bubbles formed therein for contemporaneous injection 有权
    制备其中形成有气泡的介质同时注射的方法

    公开(公告)号：US08470298B2

    公开(公告)日：2013-06-25

    申请号：US10798876

    申请日：2004-03-11

    申请人： Arthur E Uber, III ,  David M Griffiths

    发明人： Arthur E Uber, III ,  David M Griffiths

    IPC分类号： A61B8/00 ,  A61K49/00

    CPC分类号： A61K49/223 ,  A61B8/4281 ,  A61M5/007 ,  A61M5/142 ,  A61M5/145 ,  A61M5/165 ,  A61M5/16831 ,  A61M2005/006 ,  A61M2205/11 ,  A61M2230/30

    摘要： An apparatus, system or method enables microbubbles to be created on demand for use as the contrast agent within a contrast medium administrable to a patient for purposes of a medical procedure. The system comprises a reservoir, a pressurizing device, a microbubble generator, and a controller. The reservoir stores a liquid. The pressurizing device conveys the liquid, along with the medium formed therewith, through the system. The microbubble generator is used to create the microbubbles within the liquid to form the medium. The microbubble generator has an inlet for receiving the liquid and an outlet for communication of the medium to the patient. The controller controls the operation of the system so that the microbubbles created by the microbubble generator are generated according to the demands of the medical procedure and are administrable within the medium to the patient.

    摘要翻译： 一种装置，系统或方法使得可以根据需要创建微泡，以用作可用于医疗程序的患者的造影剂中的造影剂。 该系统包括储存器，加压装置，微泡发生器和控制器。 储存器储存液体。 加压装置与其形成的介质一起输送液体通过该系统。 微泡发生器用于在液体内产生微泡以形成介质。 微泡发生器具有用于接收液体的入口和用于将介质与患者通信的出口。 控制器控制系统的操作，使得由微泡发生器产生的微泡根据医疗程序的要求产生，并且可以在介质内向患者施用。

    System for processing cells and container for use therewith
    8.
    发明授权
    System for processing cells and container for use therewith 有权
    用于处理细胞和容器的系统

    公开(公告)号：US08414765B2

    公开(公告)日：2013-04-09

    申请号：US12732250

    申请日：2010-03-26

    申请人： Arthur E. Uber ,  Mark Trocki ,  Frederick W. Trombley

    发明人： Arthur E. Uber ,  Mark Trocki ,  Frederick W. Trombley

    IPC分类号： A61M5/31

    CPC分类号： A61J1/1443 ,  A61J1/1456 ,  A61J1/1475 ,  A61M5/142 ,  A61M5/1723 ,  A61M5/3145 ,  A61M31/005 ,  B01L3/502 ,  B01L2300/044 ,  B01L2300/0681 ,  G06F19/3468

    摘要： A system for processing cells is disclosed. The system may include a container having an inner wall, a plunger adapted to be slidably positioned within the container, at least one inlet port through which a fluid can enter the container, at least one outlet port through which a fluid can exit the container, at least one effluent port through which an effluent can exit the container, a first check valve in fluid connection with the inlet port and a second check valve in fluid connection with the effluent port. The plunger may include a filter that allows fluid to pass therethrough but prevents cells from passing therethrough. Rearward motion of the plunger may be adapted to draw fluid into the system via the inlet port and forward motion of the plunger may be adapted to force effluent out of the system via the effluent port.

    摘要翻译： 公开了一种用于处理单元的系统。 该系统可以包括容器，其具有内壁，适于可滑动地定位在容器内的柱塞，至少一个入口，流体可以通过该入口进入容器，至少一个出口，流体可以通过该出口离开容器， 至少一个流出物出口可以离开容器的第一止回阀，与入口端口流体连接的第一止回阀和与流出物端口流体连接的第二止回阀。 柱塞可以包括允许流体通过其但防止细胞通过的过滤器。 柱塞的向后运动可以适于通过入口将流体引入系统，并且柱塞的向前运动可以适于通过流出物端口将流出物强制流出系统。

    Systems and methods of determining patient transfer functions and modeling patient response to a pharmaceutical injection
    9.
    发明授权
    Systems and methods of determining patient transfer functions and modeling patient response to a pharmaceutical injection 有权
    确定患者转移功能并建立患者对药物注射的反应的系统和方法

    公开(公告)号：US08295914B2

    公开(公告)日：2012-10-23

    申请号：US11575846

    申请日：2005-11-16

    申请人： John F. Kalafut ,  Arthur E. Uber, III

    发明人： John F. Kalafut ,  Arthur E. Uber, III

    IPC分类号： A61B6/00

    CPC分类号： A61M5/007 ,  A61B5/0044 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/029 ,  A61B5/0295 ,  A61B5/055 ,  A61B5/7257 ,  A61B6/032 ,  A61B6/481 ,  A61B6/504 ,  A61B6/507 ,  A61B6/583 ,  A61B8/13 ,  A61B8/481 ,  A61K49/0002 ,  G01R33/5601 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468 ,  G16H50/50

    摘要： A method of controlling an injector system for delivering a contrast enhancing fluid to a patient. The method includes the step of determining at least one patient transfer function for the patient based upon data specific to the patient, with the at least one patient transfer function providing a time enhancement output for a given input. The data specific to the patent may include at least one of an estimate of physiologic parameters of the patient, an estimate of anatomic parameters of the patient and an enhancement caused by an injection of the contrast enhancing fluid into the patient. Other steps involve: determining a desired time enhancement output; using the at least one patient transfer function to determine an injection procedure input; and controlling the injector system at least in part on the basis of the determined injection procedure input.

    摘要翻译： 一种控制用于将对比度增强流体输送给患者的注射器系统的方法。 该方法包括基于患者特有的数据确定患者的至少一个患者传递功能的步骤，其中所述至少一个患者传递函数为给定输入提供时间增强输出。 该专利特有的数据可以包括对患者的生理参数的估计，患者的解剖学参数的估计和通过将对比度增强流体注入患者而引起的增强中的至少一个。 其他步骤包括：确定期望的时间增强输出; 使用所述至少一个患者传递函数来确定注射过程输入; 以及至少部分地基于所确定的喷射过程输入来控制喷射器系统。

    Device and Method for Determining Activity of Radiopharmaceutical Material
    10.
    发明申请
    Device and Method for Determining Activity of Radiopharmaceutical Material 有权
    放射性药物材料活性测定装置及方法

    公开(公告)号：US20120074330A1

    公开(公告)日：2012-03-29

    申请号：US12664653

    申请日：2009-12-14

    申请人： Chad E. Bouton ,  Arthur E. Uber, III

    发明人： Chad E. Bouton ,  Arthur E. Uber, III

    IPC分类号： G01T1/16 ,  G01T1/00

    CPC分类号： G01T7/02 ,  A61M5/007

    摘要： A detector system measures radioactive material. A fluid path receives at least one aliquot of radiopharmaceutical. The fluid path locates the aliquot within a positioner formed with a concave configuration. A detector is located at an axial distance from the concave surface and determines the level of radioactivity of the aliquot. Alternatively, the fluid path may be less concave and a variable attenuator may be placed between the fluid path and detector. The variable attenuator may have a concavity that is based on the concavity of the fluid path so that the detector's ability to read the radioactivity is optimized. A method for forming an aliquot of radiopharmaceutical in a concave fluid passage. Positioning a detector located a distance from the concave surface to optimize reading spectral energy of the aliquot and activity is determining activity regardless of the position of the aliquot in the passage.

    摘要翻译： 检测器系统测量放射性物质。 流体路径接收至少一个等分的放射性药物。 流体路径将等分试样定位在形成有凹形构型的定位器内。 检测器位于距凹面的轴向距离处，并确定等分试样的放射性水平。 或者，流体路径可以较少凹入，并且可变衰减器可以放置在流体路径和检测器之间。 可变衰减器可以具有基于流体路径的凹部的凹度，使得检测器读取放射性的能力被优化。 还描述了在凹形流体通道中形成放射性药物的等分试样的方法。 定位一个与凹面相距一定距离的检测器，通过确定活动而不考虑通道中等分试样的位置，优化读取等分试样的光谱能量和活性。