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1.发明授权Polyoxaester suspending vehicles for use with implantable delivery systems 有权Polyoxaester悬挂车辆与植入式输送系统一起使用公开(公告)号：US07959938B2
公开(公告)日：2011-06-14
申请号：US11374228
申请日：2006-03-13
IPC分类号： A61F13/00
CPC分类号： A61K9/0024 , A61K9/0004
摘要： Liquid polyoxaester polymer materials are provided as suspending vehicles suitable for dispensing of pharmaceutically active agents, such as proteins, from delivery devices, for example, pump-driven dosage forms. Polyoxaesters are made from at least one diacid and at least one diol. Through the use of polyoxaesters virtually solvent-free pharmaceutical suspensions can be created.
摘要翻译： 液态聚氧乙烯聚合物材料被提供为适合于从递送装置例如泵驱动剂型分配药物活性剂如蛋白质的悬浮载体。 多氧酯由至少一种二酸和至少一种二醇制成。 通过使用聚氧乙烯醚，可以制成无溶剂的药物悬浮液。
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公开(公告)号：US20070298075A1
公开(公告)日：2007-12-27
申请号：US11759327
申请日：2007-06-07
申请人： Maureen Borgia , Hassan Chaouk , Han Cui , Walter Laredo , Zhigang Li , Aruna Nathan , Michael Trezza
发明人： Maureen Borgia , Hassan Chaouk , Han Cui , Walter Laredo , Zhigang Li , Aruna Nathan , Michael Trezza
CPC分类号： A61F9/00772 , A61F9/0017 , A61M31/002
摘要： The invention provides punctal plugs for the delivery of active agent to one or both of the tear fluid of the eye and to the nasolacrimal duct. The plugs of the invention have a body, a reservoir contained within the body, and optionally a collarette. The reservoir has at least one opening and contains a polymeric material and at least one active agent.
摘要翻译： 本发明提供了用于将活性剂递送到眼睛的泪液和鼻泪管中的一种或两种的泪点塞。 本发明的塞子具有主体，容纳在主体内的储存器，以及可选地是围兜。 储存器具有至少一个开口并且包含聚合材料和至少一种活性剂。
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公开(公告)号：US20060034797A1
公开(公告)日：2006-02-16
申请号：US10522456
申请日：2003-04-24
申请人： Albertina Arien , Marcus Brewster , Aruna Nathan , Joel Rosenblatt , Louisa Ould-Ouali , Veronique Preat
发明人： Albertina Arien , Marcus Brewster , Aruna Nathan , Joel Rosenblatt , Louisa Ould-Ouali , Veronique Preat
IPC分类号： C08K5/07 , A61K31/765
CPC分类号： A61K47/34 , A61K9/1075 , A61K31/505 , A61K31/765 , C08G63/64 , C08G63/664 , C08G64/183 , C08G2261/126 , C08L67/00 , C08L71/00 , C08L2205/05 , C08L2666/18
摘要： The invention provides novel self-emulsifying diblock copolymers and novel self-emulsifying compositions comprising an active ingredient and a diblock copolymer characterized in that the diblock copolymer is liquid at a temperature below 50° C. and the composition is non-aqueous and liquid at a temperature below 50° C.
摘要翻译： 本发明提供新颖的自乳化二嵌段共聚物和新型的自乳化组合物，其包含活性成分和二嵌段共聚物，其特征在于二嵌段共聚物在低于50℃的温度下为液体，组合物为非水性且液体为 温度低于50℃
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4.发明授权Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon 失效聚（环氧烷）氨基酸共聚物和药物载体和基于其的带电共聚物
公开(公告)号：US5455027A
公开(公告)日：1995-10-03
申请号：US23069
申请日：1993-02-25
IPC分类号： A61K47/30 , A61K47/48 , A61K49/00 , A61L15/26 , A61L27/18 , C08G63/685 , C08G65/32 , C08G69/10 , C08G69/40 , C08G69/44 , C08G81/00 , H01M6/18 , A61K31/74 , A61K31/765 , A61K31/785
CPC分类号： A61K47/48315 , A61K47/48215 , A61L15/26 , A61L27/18 , C08G63/6854 , C08G81/00 , Y10S530/81
摘要： Copolymers of poly(alkylene oxides) and amino acids or peptide sequences are disclosed, which amino acids or peptide sequences have pendant functional groups that are capable of being conjugated with pharmaceutically active compounds for drug delivery systems and cross-linked to form polymer matrices functional as hydrogel membranes. The copolymers can also be formed into conductive materials. Methods are also disclosed for preparing the polymers and forming the drug conjugates, hydrogel membranes and conductive materials.
摘要翻译： 公开了聚（环氧烷）和氨基酸或肽序列的共聚物，其中氨基酸或肽序列具有侧链官能团，其能够与用于药物递送系统的药学活性化合物缀合并交联以形成作为 水凝胶膜。 共聚物也可以形成导电材料。 还公开了制备聚合物并形成药物共轭物，水凝胶膜和导电材料的方法。
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5.发明授权Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon 失效聚（环氧烷）氨基酸共聚物和药物载体和基于其的带电共聚物
公开(公告)号：US5219564A
公开(公告)日：1993-06-15
申请号：US726301
申请日：1991-07-05
IPC分类号： A61K47/30 , A61K47/48 , A61K49/00 , A61L15/26 , A61L27/18 , C08G63/685 , C08G65/32 , C08G69/10 , C08G69/40 , C08G69/44 , C08G81/00 , H01M6/18
CPC分类号： A61K47/48315 , A61K47/48215 , A61L15/26 , A61L27/18 , C08G63/6854 , C08G81/00 , Y10S530/81
摘要： Copolymers of poly(alkylene oxides) and amino acids or peptide sequences are disclosed, which amino acids or peptide sequences have pendant functional groups that are capable of being conjugated with pharmaceutically active compounds for drug delivery systems and cross-linked to form polymer matrices functional as hydrogel membranes. The copolymers can also be formed into conductive materials. Methods are also disclosed for preparing the polymers and forming the drug conjugates, hydrogel membranes and conductive materials.
摘要翻译： 公开了聚（环氧烷）和氨基酸或肽序列的共聚物，其中氨基酸或肽序列具有侧链官能团，其能够与用于药物递送系统的药物活性化合物缀合并交联以形成作为 水凝胶膜。 共聚物也可以形成导电材料。 还公开了制备聚合物并形成药物共轭物，水凝胶膜和导电材料的方法。
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公开(公告)号：US09474645B2
公开(公告)日：2016-10-25
申请号：US11759269
申请日：2007-06-07
申请人： Han Cui , Zhigang Li , Edgar V. Menezes , Aruna Nathan , Michael J. Trezza, II
发明人： Han Cui , Zhigang Li , Edgar V. Menezes , Aruna Nathan , Michael J. Trezza, II
CPC分类号： A61F9/0017 , A61F9/00772 , A61K9/0051
摘要： The invention provides punctal plugs for the delivery of active agent to one or both of the tear fluid of the eye and to the nasolacrimal duct that comprise a body, at least one cap, and optionally a collarette.
摘要翻译： 本发明提供了用于将活性剂递送到眼睛的泪液和包括身体，至少一个帽和任选的肩胛骨的鼻泪管的一个或两个的泪点。
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公开(公告)号：US20110022007A1
公开(公告)日：2011-01-27
申请号：US12779238
申请日：2010-05-13
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61F9/00772 , A61F2250/0068 , A61K9/0043 , A61K9/0051
摘要： The invention provides devices useful for the delivery of active agents to the eye in a controlled manner. In the devices of the invention, the active agent is present within the device in a continuous or discontinuous concentration gradient.
摘要翻译： 本发明提供了用于以受控方式将活性剂递送至眼睛的装置。 在本发明的装置中，活性剂以连续或不连续的浓度梯度存在于装置内。
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8.发明申请公开(公告)号：US20080075754A1
公开(公告)日：2008-03-27
申请号：US11952232
申请日：2007-12-07
申请人： Aruna Nathan , Joel Rosenblatt , Steven Arnold
发明人： Aruna Nathan , Joel Rosenblatt , Steven Arnold
CPC分类号： A61K9/0024 , A61K9/1647 , A61L27/18 , A61L27/58 , A61L31/06 , A61L31/148 , C08L67/08
摘要： The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry.
摘要翻译： 本发明涉及包含合成的，生物可吸收的生物相容性液体聚合物的医疗装置和药物组合物，其是多元酸或其衍生物，多元醇和脂肪酸的反应产物，液体聚合物的熔点小于约 40℃，通过差示扫描量热法测定。
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公开(公告)号：US20080045911A1
公开(公告)日：2008-02-21
申请号：US11759281
申请日：2007-06-07
申请人： Maureen Borgia , Hassan Chaouk , Han Cui , Walter Laredo , Zhigang Li , Aruna Nathan , Michael Trezza
发明人： Maureen Borgia , Hassan Chaouk , Han Cui , Walter Laredo , Zhigang Li , Aruna Nathan , Michael Trezza
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61F9/00772 , A61K9/0004 , A61K9/0051
摘要： The invention provides punctal plugs for the delivery of active agents. The plugs have a body throughout which at least one active agent is dispersed or that is coated with a polymeric material containing at least one active agent.
摘要翻译： 本发明提供用于递送活性剂的泪点塞。 塞子具有主体，至少一种活性剂分散在其中，或者涂覆有含有至少一种活性剂的聚合材料。
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10.发明申请Polyoxaester suspending vehicles for use with implantable delivery systems 有权Polyoxaester悬挂车辆与植入式输送系统一起使用公开(公告)号：US20060246138A1
公开(公告)日：2006-11-02
申请号：US11374228
申请日：2006-03-13
申请人： Catherine Rohloff , Stephen Berry , Ling-Ling Kang , Aruna Nathan
发明人： Catherine Rohloff , Stephen Berry , Ling-Ling Kang , Aruna Nathan
IPC分类号： A61K38/21 , A61K31/519 , A61K38/19 , A61K38/22 , A61K38/18 , A61K48/00 , A61K9/22 , A61K9/14
CPC分类号： A61K9/0024 , A61K9/0004
摘要： Liquid polyoxaester polymer materials are provided as suspending vehicles suitable for dispensing of pharmaceutically active agents, such as proteins, from delivery devices, for example, pump-driven dosage forms. Polyoxaesters are made from at least one diacid and at least one diol. Through the use of polyoxaesters virtually solvent-free pharmaceutical suspensions can be created.
摘要翻译： 液态聚氧乙烯聚合物材料被提供为适合于从递送装置例如泵驱动剂型分配药物活性剂如蛋白质的悬浮载体。 多氧酯由至少一种二酸和至少一种二醇制成。 通过使用聚氧乙烯醚，可以制成无溶剂的药物悬浮液。
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