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    Use of a liquid cooling sensate to provide a pungent, warming or tingling sensate composition
    2.
    发明申请
    Use of a liquid cooling sensate to provide a pungent, warming or tingling sensate composition 审中-公开
    使用液体冷却液提供刺激，变暖或刺痛的感觉组合物

    公开(公告)号：US20080038386A1

    公开(公告)日：2008-02-14

    申请号：US11497479

    申请日：2006-08-02

    申请人： Ashok K Moza ,  Stephen E. Rohde ,  John Charles Leffingwell ,  Diane Leffingwell

    发明人： Ashok K Moza ,  Stephen E. Rohde ,  John Charles Leffingwell ,  Diane Leffingwell

    IPC分类号： A61K36/81 ,  A61K36/31 ,  A61K31/21 ,  A61K31/26 ,  A61K31/165

    CPC分类号： A61K36/31 ,  A61K31/165 ,  A61K31/21 ,  A61K31/26

    摘要： The present invention is directed to a sensate composition consisting of a liquid cooling composition, and at least one warming, tingling, or pungent sensate ingredient of either synthetic or natural origin which provides enhanced warming, tingling, or pungent properties. The liquid cooling sensate of the invention is a eutectic mixture of 2-Isopropyl-N,2,3-trimethylbutyramide and N-Ethyl-p-menthane-3-carboxamide, or at least one cooling agent selected from the group consisting of N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide, N-(3-ethoxypropyl)-2,3-dimethyl-2-isopropylbutanamide, N-(3-isopropoxypropyl)-2,3-dimethyl-2-isopropylbutanamide, N-(3-butoxypropyl)-2,3-dimethyl-2-isopropylbutanamide,N-Ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, N-(2-ethoxyethyl)-2,3-dimethyl-2-isopropylbutanamide and N-(3-methoxypropyl)-2,3-dimethyl-2-isopropylbutanamide. The warming, tingling, or pungent sensate of the invention consists of at least one component that is an isothiocyanate and/or an amide or a natural product that contains at least one warming, tingling, or pungent principle that is an isothiocyanate and/or an amide. The present invention is further directed to a method of using the sensate composition in a food, pharmaceutical or personal care product.

    摘要翻译： 本发明涉及由液体冷却组合物和合成或天然来源的至少一种变暖，麻刺或刺激感觉成分组成的敏感组合物，其提供增强的变暖，刺痛或刺激性质。 本发明的液体冷却剂是2-异丙基-N，2,3-三甲基丁酰胺和N-乙基对薄荷烷-3-甲酰胺的共晶混合物，或至少一种选自N- （2-羟乙基）-2,3-二甲基-2-异丙基丁酰胺，N-（3-乙氧基丙基）-2,3-二甲基-2-异丙基丁酰胺，N-（3-异丙氧基丙基）-2,3-二甲基-2- 异丙基丁酰胺，N-（3-丁氧基丙基）-2,3-二甲基-2-异丙基丁酰胺，N-乙基-2,2-二异丙基丁酰胺，N-（1,1-二甲基-2-羟乙基）-2,2-二乙基丁酰胺， N-（2-乙氧基乙基）-2,3-二甲基-2-异丙基丁酰胺和N-（3-甲氧基丙基）-2,3-二甲基-2-异丙基丁酰胺。 本发明的变暖，麻刺或刺激性感觉由至少一种组分，其是异硫氰酸酯和/或酰胺或天然产物，其含有至少一种变温，刺痛或刺激性原理，其是异硫氰酸酯和/或 酰胺。 本发明还涉及在食品，药物或个人护理产品中使用感觉组合物的方法。

    Liquid composition of 2-Isopropyl-N,2,3-trimethylbutyramide and N-Ethyl-p-menthane-3-carboxamide, its preparation method and its applications as a cooling agent and flavor enhancer
    3.
    发明申请
    Liquid composition of 2-Isopropyl-N,2,3-trimethylbutyramide and N-Ethyl-p-menthane-3-carboxamide, its preparation method and its applications as a cooling agent and flavor enhancer 审中-公开
    2-异丙基-N，2,3-三甲基丁酰胺和N-乙基对薄荷烷-3-甲酰胺的液体组成，其制备方法及其作为冷却剂和风味增强剂的应用

    公开(公告)号：US20070048424A1

    公开(公告)日：2007-03-01

    申请号：US11217188

    申请日：2005-09-01

    申请人： Ashok Moza ,  Hong Sun ,  John Leffingwell ,  Diane Leffingwell ,  Stephen Rohde

    发明人： Ashok Moza ,  Hong Sun ,  John Leffingwell ,  Diane Leffingwell ,  Stephen Rohde

    IPC分类号： A23L1/22

    CPC分类号： A23L27/202 ,  A23L27/88

    摘要： Disclosed is a liquid composition containing N-Ethyl-p-menthane-3-carboxamide and 2-Isopropyl-N,2,3-trimethylbutyramide (popularly known as WS-3 and WS-23 respectively), its preparation and its applications as a cooling sensate and as a flavoring agent. The present invention provides a composition characterized in that it comprises N-Ethyl-p-menthane-3-carboxamide and 2-Isopropyl-N,2,3-trimethylbutyramide in a ratio by weight in the range of 60/40 to 30/70 with the corresponding crystallization point being below 15° C. Preferably a weight ratio of 52/48 to 42/58 is employed corresponding to a crystallization point below −20° C. Such compositions have the advantages of being liquid at room temperature, easy to use as a cooling agent or a flavoring agent with no need to melt the normally crystalline forms of 2-Isopropyl-N,2,3-trimethylbutyramide (melting point 62° C.) and N-Ethyl-p-menthane-3-carboxamide (melting point 98.7° C.). The liquid cooling compositions herein described not only saves handling time, but also simplifies manufacturing processes by eliminating the need for extensive dust control procedures and can be used in cold processes at room temperature. These liquid compositions are effective not just as cooling agents, but at low levels act as flavor and salt enhancers.

    摘要翻译： 公开了含有N-乙基对薄荷烷-3-甲酰胺和2-异丙基-N，2,3-三甲基丁酰胺（俗称WS-3和WS-23）的液体组合物，其制备及其应用为 冷却感和作为调味剂。 本发明提供一种组合物，其特征在于其包含N-乙基对薄荷烷-3-甲酰胺和2-异丙基-N，2,3-三甲基丁酰胺，其重量比在60/40至30/70的范围内 相应的结晶点低于15℃。对应于低于-20℃的结晶点，优选使用52/48至42/58的重量比。这种组合物的优点是在室温下为液体，容易 用作冷却剂或调味剂，不需要熔化2-异丙基-N，2,3-三甲基丁酰胺（熔点62℃）和N-乙基对薄荷烷-3-甲酰胺的正常结晶形式 （熔点98.7℃）。 本文描述的液体冷却组合物不仅节省了处理时间，而且通过消除对广泛的粉尘控制程序的需要简化了制造过程，并且可以在室温的冷加工中使用。 这些液体组合物不仅作为冷却剂是有效的，而是在低水平上起到风味和盐增强剂的作用。