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公开(公告)号:US20070093510A1
公开(公告)日:2007-04-26
申请号:US10636979
申请日:2003-08-08
申请人: Ashok Tehim , Allen Hopper , Ruiping Liu , Hans-Jurgen Hess , Yajing Rong
发明人: Ashok Tehim , Allen Hopper , Ruiping Liu , Hans-Jurgen Hess , Yajing Rong
IPC分类号: A61K31/52 , C07D473/14
CPC分类号: C07D473/34 , C07D473/14
摘要: PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein.
摘要翻译: 通过式I的新化合物实现PDE4抑制:其中R 1和R 2如本文所定义。
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公开(公告)号:US20110046146A9
公开(公告)日:2011-02-24
申请号:US11602283
申请日:2006-11-21
申请人: Richard Schumacher , William Brubaker , Michael De Vivo , Hans-Jurgen Hess , Allen Hopper , Ashok Tehim , Ruiping Liu , Axel Unterbeck
发明人: Richard Schumacher , William Brubaker , Michael De Vivo , Hans-Jurgen Hess , Allen Hopper , Ashok Tehim , Ruiping Liu , Axel Unterbeck
IPC分类号: A61K31/505 , A61K31/4965 , A61K31/44 , A61K31/426 , A61K31/47 , A61K31/381 , A61K31/34 , A61K31/137
CPC分类号: C07D213/74 , A61K31/137 , A61K31/16 , A61K31/34 , A61K31/381 , A61K31/426 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/4965 , A61K31/505 , C07C217/92 , C07C229/60 , C07D211/26 , C07D213/38 , C07D213/61 , C07D213/80 , C07D215/12 , C07D217/22 , C07D241/12 , C07D277/28 , C07D307/20 , C07D307/52 , C07D317/58 , C07D333/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07F7/1804
摘要: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3and R4 are as defined herein.
摘要翻译: 通过新化合物,例如N-取代的苯胺和二苯胺类似物来实现PDE4的抑制。 本发明的化合物具有式I:其中R 1,R 2,R 3和R 4如本文所定义。
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公开(公告)号:US07342021B2
公开(公告)日:2008-03-11
申请号:US10067996
申请日:2002-02-08
申请人: Ruiping Liu , Hans-Jurgen Ernst Hess , Allen Hopper , Ashok Tehim , Yajing Rong
发明人: Ruiping Liu , Hans-Jurgen Ernst Hess , Allen Hopper , Ashok Tehim , Yajing Rong
IPC分类号: C07D473/34 , A61K31/52 , A61P37/08 , A61P25/28 , A61P29/00
CPC分类号: C07D473/40
摘要: PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein.
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公开(公告)号:US20070078139A1
公开(公告)日:2007-04-05
申请号:US11602283
申请日:2006-11-21
申请人: Richard Schumacher , William Brubaker , Michael De Vivo , Hans-Jurgen Hess , Allen Hopper , Ashok Tehim , Ruiping Liu , Axel Unterbeck
发明人: Richard Schumacher , William Brubaker , Michael De Vivo , Hans-Jurgen Hess , Allen Hopper , Ashok Tehim , Ruiping Liu , Axel Unterbeck
IPC分类号: A61K31/505 , A61K31/4965 , A61K31/44 , A61K31/426 , A61K31/47 , A61K31/381 , A61K31/34 , A61K31/137
CPC分类号: C07D213/74 , A61K31/137 , A61K31/16 , A61K31/34 , A61K31/381 , A61K31/426 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/4965 , A61K31/505 , C07C217/92 , C07C229/60 , C07D211/26 , C07D213/38 , C07D213/61 , C07D213/80 , C07D215/12 , C07D217/22 , C07D241/12 , C07D277/28 , C07D307/20 , C07D307/52 , C07D317/58 , C07D333/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07F7/1804
摘要: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3and R4 are as defined herein.
摘要翻译: 通过新化合物,例如N-取代的苯胺和二苯胺类似物来实现PDE4的抑制。 本发明的化合物是式I的化合物:其中R 1,R 2,R 3和R 4, >如本文所定义。
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公开(公告)号:US20080139583A1
公开(公告)日:2008-06-12
申请号:US12026198
申请日:2008-02-05
IPC分类号: A61K31/52 , A61P25/28 , C07D473/32
CPC分类号: C07D473/34 , C07D473/14
摘要: PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein.
摘要翻译: 通过式I的新化合物实现PDE4抑制:其中R 1和R 2如本文所定义。
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公开(公告)号:US20100004236A1
公开(公告)日:2010-01-07
申请号:US12393634
申请日:2009-02-26
IPC分类号: A61K31/52 , C07D473/34 , A61P25/28 , A61P25/18 , A61P25/36 , A61P25/24 , A61P11/00 , A61P37/08 , A61P29/00 , A61P25/16 , A61P9/00 , A61P31/18 , C07D413/14 , A61K31/5377 , A61K31/496
CPC分类号: C07D473/34 , C07D473/14
摘要: PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein.
摘要翻译: 通过式I的新化合物实现PDE4抑制:其中R1和R2如本文所定义。
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公开(公告)号:US07332486B2
公开(公告)日:2008-02-19
申请号:US10636979
申请日:2003-08-08
IPC分类号: C07D473/40 , A61K31/52 , A61P25/24 , A61P25/18 , A61P25/28
CPC分类号: C07D473/34 , C07D473/14
摘要: PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein.
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公开(公告)号:US07696198B2
公开(公告)日:2010-04-13
申请号:US10825610
申请日:2004-04-16
申请人: Ashok Tehim , Allen Hopper , Ruiping Liu , Erik Kuester , Robert F. Dunn , Thomas E. Renau
发明人: Ashok Tehim , Allen Hopper , Ruiping Liu , Erik Kuester , Robert F. Dunn , Thomas E. Renau
IPC分类号: A61K31/54 , A61K31/425 , C07D417/02 , C07D413/02 , C07D405/00
CPC分类号: C07D207/26 , C07D405/12 , C07D417/14
摘要: Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: wherein R1, R2, and R3 are as defined herein.
摘要翻译: 选择性PDE4抑制由4-(取代的 - 苯基)-2-吡咯烷酮化合物实现。 与化合物如咯利普兰相比,化合物表现出改善的PDE4抑制,并且显示关于抑制其它类别的PDE的选择性。 本发明的化合物具有式I:其中R 1,R 2和R 3如本文所定义。
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公开(公告)号:US07585882B2
公开(公告)日:2009-09-08
申请号:US11253812
申请日:2005-10-20
申请人: Allen Hopper , Robert Francis Dunn , Erik Mikal Kuester , Richard Dennis Conticello , Ruiping Liu , Ashok Tehim
发明人: Allen Hopper , Robert Francis Dunn , Erik Mikal Kuester , Richard Dennis Conticello , Ruiping Liu , Ashok Tehim
IPC分类号: A61K31/4015 , A61K31/4025 , A61K31/433 , C07D207/12 , C07D285/08 , C07D403/12 , A61K31/341 , C07D407/10 , C07D407/14
CPC分类号: C07D207/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I: wherein R1, R2, and R3 are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
摘要翻译: 选择性PDE4的抑制是通过新的化合物,例如4-(取代的 - 苯基)-2-吡咯烷酮化合物实现的。 本发明的化合物具有式I:其中R 1,R 2和R 3如本文所定义。 本公开还涉及制备这种化合物的方法,含有这些化合物的组合物及其使用方法。
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10.Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors 失效
标题翻译: 某些噻吩并嘧啶衍生物作为磷酸二酯酶10抑制剂公开(公告)号:US20070259896A1
公开(公告)日:2007-11-08
申请号:US11317907
申请日:2005-12-22
申请人: Ruiping Liu , Mark Arrington , Allen Hopper , Ashok Tehim
发明人: Ruiping Liu , Mark Arrington , Allen Hopper , Ashok Tehim
IPC分类号: A61K31/519 , A61P25/16 , A61P25/18 , A61P25/28 , A61P3/04 , A61P3/10 , C07D495/04
CPC分类号: C07D495/04
摘要: Certain thienopyrimidine derivatives are useful for the inhibition of PDE10 enzymes, and thus are useful for treating psychiatric or neurological syndromes, e.g., pyschoses, obsessive-compulsive disorder and/or Parkinson's disease, as well as, for example, treating a disease state modulated by PDE10 activity.
摘要翻译: 某些噻吩并嘧啶衍生物可用于抑制PDE10酶,因此可用于治疗精神病学或神经系统综合征,例如睡眠障碍,强迫症和/或帕金森病,以及例如治疗由 PDE10活动。
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